公开(公告)号：US20240262901A1

公开(公告)日：2024-08-08

申请号：US18638307

申请日：2024-04-17

Applicant: AbbVie Deutschland GmbH & Co. KG ,  AbbVie Inc.

Inventor： Bernhard Mueller ,  Andreas Popp ,  Jennifer M. Perez

IPC: C07K16/18 ,  A61K39/00 ,  C07K16/28 ,  G01N33/566

CPC classification number: C07K16/18 ,  C07K16/28 ,  G01N33/566 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/92

Abstract: Provided herein are methods of using the antibodies that bind to RGMc to treat and diagnose iron-related disorders.

公开(公告)号：US20230174645A1

公开(公告)日：2023-06-08

申请号：US17924672

申请日：2021-05-13

Applicant: Disc Medicine, Inc. ,  AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Maria Beconi ,  John Quisel ,  Brian MacDonald ,  Steven Robinette ,  Bernhard Mueller ,  Andreas Popp ,  Jennifer M. Perez

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/28 ,  A61P35/00 ,  C07K2317/565 ,  C07K2317/24

Abstract: Aspects of the application provide anti-hemojuvelin antibodies and methods of using the same in treating myelofibrosis and/or conditions associated with myelofibrosis.

公开(公告)号：US20210155681A1

公开(公告)日：2021-05-27

申请号：US17034454

申请日：2020-09-28

Applicant: AbbVie Deutschland GmbH & Co. KG ,  AbbVie Inc.

Inventor： Bernhard Mueller ,  Andreas Popp ,  Jennifer M. Perez

IPC: C07K16/18 ,  G01N33/566 ,  C07K16/28

Abstract: Provided herein are methods of using the antibodies that bind to RGMc to treat and diagnose iron-related disorders.

公开(公告)号：US10118958B2

公开(公告)日：2018-11-06

申请号：US13714238

申请日：2012-12-13

Applicant: AbbVie Deutschland GmbH & Co. KG ,  AbbVie Inc.

Inventor： Bernhard Mueller ,  Andreas Popp ,  Jennifer M. Perez

IPC: A61K39/395 ,  C07K16/18 ,  G01N33/566 ,  C07K16/28 ,  A61K39/00

Abstract: Provided herein are methods of using the antibodies that bind to RGMc to treat and diagnose iron-related disorders.

公开(公告)号：US20240417458A1

公开(公告)日：2024-12-19

申请号：US18710958

申请日：2022-11-16

Applicant: Disc Medicine, Inc. ,  AbbVie Deutschland GmbH & Co. KG ,  AbbVie Inc.

Inventor： Brian MacDonald ,  John Quisel ,  Will Savage ,  Hua Yang ,  Jonathan Yu ,  Min Wu ,  Maria Beconi ,  Jennifer M. Perez ,  Bernhard Mueller ,  Andreas Popp

IPC: C07K16/28 ,  A61P7/06

Abstract: Aspects of the application provide hemojuvelin antagonists and methods of using the same in treating anemias of kidney disease and conditions associated with these anemias. Methods provided in the application relate to treatment of a subject having an anemia associated with chronic kidney disease and/or kidney disease in a subject that has a level of glomerular filtration rate lower than one or more thresholds.

公开(公告)号：US20210238270A1

公开(公告)日：2021-08-05

申请号：US17024459

申请日：2020-09-17

Applicant: AbbVie Deutschland GmbH & Co. KG ,  AbbVie Inc.

Inventor： Bernhard Mueller ,  Lili Huang ,  Philip D. Bardwell ,  Yuliya Kutskova ,  John Memmott

IPC: C07K16/22 ,  C07K16/28 ,  C07K16/18 ,  A61K39/395 ,  A61K49/00 ,  A61K51/10 ,  G01N33/68 ,  C07B59/00

Abstract: Provided herein are antibodies and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders.

公开(公告)号：US20190292244A1

公开(公告)日：2019-09-26

申请号：US16179515

申请日：2018-11-02

Applicant: AbbVie Deutschland GmbH & Co. KG ,  AbbVie Inc.

Inventor： Bernhard Mueller ,  Andreas Popp ,  Jennifer M. Perez

IPC: C07K16/18 ,  C07K16/28 ,  G01N33/566

Abstract: Provided herein are methods of using the antibodies that bind to RGMc to treat and diagnose iron-related disorders.

公开(公告)号：US20160326240A1

公开(公告)日：2016-11-10

申请号：US15155815

申请日：2016-05-16

Applicant: ABBVIE DEUTSCHLAND GMBH & CO. KG ,  ABBVIE INC.

Inventor： Bernhard Mueller ,  Lili Huang ,  Philip D. Bardwell ,  Yuliya Kutskova ,  John Memmott

IPC: C07K16/22 ,  A61K51/10 ,  G01N33/68 ,  C07B59/00

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K49/0002 ,  A61K49/0058 ,  A61K51/1018 ,  A61K51/1021 ,  A61K2039/505 ,  C07B59/008 ,  C07B2200/05 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/76 ,  G01N33/6896 ,  G01N2333/705 ,  G01N2800/28 ,  G01N2800/285

Abstract: Provided herein are antibodies and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders.

公开(公告)号：US09365643B2

公开(公告)日：2016-06-14

申请号：US14580818

申请日：2014-12-23

Applicant: AbbVie Deutschland GmbH & Co. KG ,  AbbVie Inc.

Inventor： Bernhard Mueller ,  Lili Huang ,  Philip D. Bardwell ,  Yuliya Kutskova ,  John Memmott

IPC: C07K16/22 ,  C07K16/18 ,  A61K39/395 ,  C07K16/28 ,  A61K49/00 ,  A61K51/10 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K49/0002 ,  A61K49/0058 ,  A61K51/1018 ,  A61K51/1021 ,  A61K2039/505 ,  C07B59/008 ,  C07B2200/05 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/76 ,  G01N33/6896 ,  G01N2333/705 ,  G01N2800/28 ,  G01N2800/285

Abstract: Provided herein are antibodies that bind to Repulsive Guidance Molecule a (RGMa) and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders.

Abstract translation: 本文提供了结合排斥导向分子a（RGMa）的抗体以及使用抗体治疗和诊断神经突变性疾病和病症的方法。

公开(公告)号：US20250084162A1

公开(公告)日：2025-03-13

申请号：US18896718

申请日：2024-09-25

Applicant: Disc Medicine, Inc. ,  AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Maria Beconi ,  John Quisel ,  Brian MacDonald ,  Steven Robinette ,  Bernhard Mueller ,  Andreas Popp ,  Jennifer M. Perez

IPC: C07K16/28 ,  A61P35/00

Abstract: Aspects of the application provide anti-hemojuvelin antibodies and methods of using the same in treating myelofibrosis and/or conditions associated with myelofibrosis.