公开(公告)号：US20230175968A1

公开(公告)日：2023-06-08

申请号：US17922349

申请日：2021-04-30

Applicant: Agency for Science, Technology and Research

Inventor： Malini Olivo ,  Jayakumar Perumal ,  Mohesh Moothanchery ,  Gurpreet Singh

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01N2201/0221 ,  G01N2201/06113 ,  G01N2021/0106

Abstract: A portable device which detects a Raman signal from an analyte of interest contained in or suspected to contain in a sample. The portable device includes a laser source in optical communication with a dichroic mirror, an objective lens optically positioned to consolidate the laser from the laser source to the sample, (i) a pair of rotatable filters in optical communication with the dichroic mirror and an optical transmission module or (ii) a first band-pass filter in optical communication with the dichroic mirror and an optical transmission module, and a detector optically positioned to receive and detect a Raman signal produced from the laser incident on the analyte of interest. The dichroic mirror directs the laser from the laser source to the sample through the objective lens and transmits any Raman signal from the sample toward the detector. The detector is absent of a spectrometer and detects the Raman signal.

公开(公告)号：US11419520B2

公开(公告)日：2022-08-23

申请号：US16612722

申请日：2018-05-15

Applicant: Agency for Science, Technology and Research

Inventor： Malini Olivo ,  Gurpreet Singh ,  Renzhe Bi

IPC: A61B5/08 ,  A61B5/113 ,  A61B5/00

Abstract: Method for measuring respiratory vibration on a human or animal skin, including emitting an emission light at a first position on the skin and receiving a diffused light from the emission light at a second position on the skin; storing a vibration signal including a light intensity of the diffused light received over time; wherein the vibration signal corresponds to a mechanical vibration of the skin, and extracting a respiratory parameter from the vibration signal. In particular, at least one of the first position and the second position is in proximity to or at a trachea, a neck or a chest. The system for carrying out the method includes an emitter, a receiver, a circuit, and a processing unit. A set of a sensor module and a skin adhesive patch is also provided.

公开(公告)号：US20200163591A1

公开(公告)日：2020-05-28

申请号：US16612722

申请日：2018-05-15

Applicant: Agency for Science, Technology and Research

Inventor： Malini Olivo ,  Gurpreet Singh ,  Renzhe Bi

IPC: A61B5/11 ,  A61B5/113 ,  A61B5/00

Abstract: Method for measuring respiratory vibration on a human or animal skin, including emitting an emission light at a first position on the skin and receiving a diffused light from the emission light at a second position on the skin; storing a vibration signal including a light intensity of the diffused light received over time; wherein the vibration signal corresponds to a mechanical vibration of the skin, and extracting a respiratory parameter from the vibration signal. In particular, at least one of the first position and the second position is in proximity to or at a trachea, a neck or a chest. The system for carrying out the method includes an emitter, a receiver, a circuit, and a processing unit. A set of a sensor module and a skin adhesive patch is also provided.

公开(公告)号：US11635327B2

公开(公告)日：2023-04-25

申请号：US16499601

申请日：2018-03-29

Applicant: Agency for Science, Technology and Research

Inventor： Malini Olivo ,  Gurpreet Singh ,  Renzhe Bi ,  Kapil Dev ,  Dinish Unnimadhava Kurup Soudamini Amma ,  Chris Jun Hui Ho

IPC: G01J3/02 ,  G01J3/44 ,  G01N21/65

Abstract: Provided is an optical probe, and a Raman spectroscopy system using such, including excitation and detection optics coupled to a sampling optics via a beam splitter, in confocal arrangement with a sample focal plane of the sampling optics. The detection optics is arranged to receive Raman signal from the sample focal plane and direct it onto a tip of a detection optical fiber. The optical probe may further include a positioning device mechanically coupled to the sampling optics and configured to control a position of the sample focal plane. In the Raman spectroscopy system a light source is coupled to the excitation optics via an excitation optical fiber, and a spectrometer is coupled to a detection optics via a detection optical fiber. Provided is further a method for measuring Raman signal depth profile in a sample, wherein sample's Raman spectra is measured and stored at different focal plane positions.