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    DEVICE AND METHOD FOR DETERMINING PARAMETERS REGARDING A CONTENT OR PROPERTY OF BIOMOLECULES IN BIOLOGICAL TISSUES
    4.
    发明公开
    DEVICE AND METHOD FOR DETERMINING PARAMETERS REGARDING A CONTENT OR PROPERTY OF BIOMOLECULES IN BIOLOGICAL TISSUES 审中-公开

    公开(公告)号：US20240241039A1

    公开(公告)日：2024-07-18

    申请号：US18580063

    申请日：2022-07-22

    Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

    Inventor： Miguel Angel Pleitez Rafael ,  Vasilis Ntziachristos

    IPC: G01N21/17

    CPC classification number: G01N21/1702 ,  G01N2201/0221 ,  G01N2291/02475

    Abstract: The invention relates to a device and a method for determining one or more parameters regarding a content and/or property of biomolecules, in particular metabolites, in a biological tissue (11). The device comprises at least one irradiation unit (1) configured to irradiate the tissue (11) with electromagnetic radiation (2) exhibiting one or more wavelengths or wavelength ranges, in particular in the mid-infrared, near-infrared and/or visible spectral range, at least one detection unit (8, 12) configured to detect, in a spatially resolved manner, first signals corresponding to optical and/or optoacoustic and/or optothermal signals emanating from the tissue (11) in response to irradiating the tissue (11) with electromagnetic radiation (2), in particular in the near-infrared and/or visible spectral range, wherein the at least one irradiation unit (1) and the at least one detection unit (8, 12) are located in the same half space above and/or adjacent to the irradiated tissue (11), and a processing unit (14) configured i) to localize, based on the detected first signals, a location or region of interest on and/or within the tissue (11), at which at least one biomolecule of interest is present or expected, ii) to control the at least one irradiation unit (1) to irradiate the location or region of interest on and/or within the tissue (11) with electromagnetic radiation (2) exhibiting a time-varying intensity and one or more wavelengths or wavelength ranges in the mid-infrared spectral range, iii) to control the at least one detection unit (8, 12) to detect second signals corresponding to optoacoustic and/or optothermal signals emanating from the irradiated location or region of interest on and/or within the tissue (11) in response to irradiating the location or region of interest on and/or within the tissue (11) with the electromagnetic radiation (2) in the mid-infrared spectral range, and iv) to determine, based on the detected second signals, one or more parameters regarding a content and/or property of the at least one biomolecule, in particular metabolite, of interest at the location or region of interest on and/or within in the tissue (11).

    System and method for on-board data analysis for multi-gas sensing
    8.
    发明授权
    System and method for on-board data analysis for multi-gas sensing 有权

    公开(公告)号：US11977025B2

    公开(公告)日：2024-05-07

    申请号：US17859904

    申请日：2022-07-07

    Applicant: General Electric Company

    Inventor： Radislav Alexandrovich Potyrailo ,  Baokai Cheng ,  Aghogho Atemu Obi ,  Christopher Collazo-Davila ,  Richard Jean-Luc St. Pierre

    IPC: G01N21/3504 ,  G01N33/00

    CPC classification number: G01N21/3504 ,  G01N33/0006 ,  G01N2201/0221

    Abstract: Gas sensors are disclosed having an on-board, low-power data processor that uses multivariable gas classification and/or gas quantitation models to perform on-board data processing to resolve two or more gases in a fluid sample. To reduce computational complexity, the gas sensor utilizes low-power-consumption multivariable data analysis algorithms, inputs from available on-board sensors of ambient conditions, inputs representing contextual data, and/or excitation responses of a gas sensing material to select suitable gas classification and/or gas quantitation models. The data processor can then utilize these gas classification and quantitation models, in combination with measured dielectric responses of a gas sensing material of the gas sensor, to determine classifications and/or concentrations of two or more gases in a fluid sample, while consuming substantially less power than would be consumed if a global comprehensive model were used instead. Thus, the data processor is utilized for linear, nonlinear, and non-monotonic multivariate regressions.

    MEASUREMENT SYSTEM AND MEASUREMENT METHOD
    9.
    发明公开
    MEASUREMENT SYSTEM AND MEASUREMENT METHOD 审中-公开

    公开(公告)号：US20240133820A1

    公开(公告)日：2024-04-25

    申请号：US18479273

    申请日：2023-10-01

    Applicant: ARKRAY, Inc.

    Inventor： Fumito HIRAMURA ,  Alexander TURNER

    IPC: G01N21/84 ,  G06K7/10 ,  H04N23/74

    CPC classification number: G01N21/8483 ,  G06K7/10861 ,  H04N23/74 ,  G01N2201/0221 ,  G01N2201/0692

    Abstract: A measurement system including: an insertion gate into which a test strip including first and second regions is inserted; a holder accommodating the test strip; a housing including a window facing the test strip; and a smart device including an illuminator illuminating the second region and including a camera imaging the first and second regions, in which the housing includes a mounting part placing the smart device on an outer surface of the housing in a state in which the camera and the illuminator are disposed at positions facing the window, and a measurement light source provided at a position to irradiate the first region, and in a case in which the camera images the first region, the illuminator is turned off while the measurement light source is turned on, and in a case in which the camera images the second region, the illuminator is turned on.

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