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1.Genetically Engineered and Phenotyped Mice and Stem Cell Clones for Producing the Same 审中-公开
标题翻译: 基因工程和表型小鼠和干细胞克隆生产它公开(公告)号:US20090113564A1
公开(公告)日:2009-04-30
申请号:US12057851
申请日:2008-03-28
申请人: Alejandro Abuin , Mark Dominic Borromeo , Katherin E. Combs , Ling Ling Culbertson , Zhi-Yong Ding , Joel Edwards , Liangfen Fan , Rosemary Girgis , Leslie Jane Green , Allison Anne Byers Horner , Erin Marie Massey , Dina Rebecca McLain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Brian Zambrowicz
发明人: Alejandro Abuin , Mark Dominic Borromeo , Katherin E. Combs , Ling Ling Culbertson , Zhi-Yong Ding , Joel Edwards , Liangfen Fan , Rosemary Girgis , Leslie Jane Green , Allison Anne Byers Horner , Erin Marie Massey , Dina Rebecca McLain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Brian Zambrowicz
IPC分类号: A01K67/027
CPC分类号: C12N15/873 , A01K2217/05 , C12N2799/027
摘要: The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.
摘要翻译: 本发明涉及基因工程小鼠,衍生自这些小鼠的细胞,以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠,细胞,多核苷酸,多肽和抗体的方法。