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1.发明申请Genetically Engineered and Phenotyped Mice and Stem Cell Clones for Producing the Same 审中-公开基因工程和表型小鼠和干细胞克隆生产它公开(公告)号：US20090113564A1
公开(公告)日：2009-04-30
申请号：US12057851
申请日：2008-03-28
申请人： Alejandro Abuin , Mark Dominic Borromeo , Katherin E. Combs , Ling Ling Culbertson , Zhi-Yong Ding , Joel Edwards , Liangfen Fan , Rosemary Girgis , Leslie Jane Green , Allison Anne Byers Horner , Erin Marie Massey , Dina Rebecca McLain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Brian Zambrowicz
发明人： Alejandro Abuin , Mark Dominic Borromeo , Katherin E. Combs , Ling Ling Culbertson , Zhi-Yong Ding , Joel Edwards , Liangfen Fan , Rosemary Girgis , Leslie Jane Green , Allison Anne Byers Horner , Erin Marie Massey , Dina Rebecca McLain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Brian Zambrowicz
IPC分类号： A01K67/027
CPC分类号： C12N15/873 , A01K2217/05 , C12N2799/027
摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.
摘要翻译： 本发明涉及基因工程小鼠，衍生自这些小鼠的细胞，以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠，细胞，多核苷酸，多肽和抗体的方法。
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2.发明申请Genetically engineered and phenotyped mice and stem cell clones for producing the same 审中-公开基因工程和表型小鼠和干细胞克隆用于生产相同的公开(公告)号：US20080189799A1
公开(公告)日：2008-08-07
申请号：US11978234
申请日：2007-10-26
申请人： Liangfen Fan , Glenn Friedrich , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Peter Vogel , Brian Zambrowicz
发明人： Liangfen Fan , Glenn Friedrich , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Peter Vogel , Brian Zambrowicz
IPC分类号： C12N15/11 , A01K67/027
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2267/03 , C07K14/705 , C07K14/70503 , C07K14/7151 , C07K14/775 , C07K14/8114 , C07K14/8121 , C12N9/1051 , C12N9/12 , C12N9/1205 , C12N2799/027 , C12N2800/60
摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.
摘要翻译： 本发明涉及基因工程小鼠，衍生自这些小鼠的细胞，以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠，细胞，多核苷酸，多肽和抗体的方法。
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3.发明申请Genetically Engineered and Photyped Mice and Stem Cell Clones for Producing the Same 审中-公开基因工程和愚蠢的小鼠和干细胞克隆生产它公开(公告)号：US20090077680A1
公开(公告)日：2009-03-19
申请号：US12099465
申请日：2008-04-08
申请人： Alejandro Abuin , Joel Edwards , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Zheng-Zheng Shi , Mary Jean Sparks , Teresa Gail Townsend , Rosemary Girgis , Allison Anne Byers Horner , Peter Vogel , Brian Zambrowicz
发明人： Alejandro Abuin , Joel Edwards , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Zheng-Zheng Shi , Mary Jean Sparks , Teresa Gail Townsend , Rosemary Girgis , Allison Anne Byers Horner , Peter Vogel , Brian Zambrowicz
IPC分类号： A01K67/027 , C12N5/06 , C07K16/18
CPC分类号： A01K67/0276 , A01K2217/054 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , C12N15/8509 , C12N2840/44
摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.
摘要翻译： 本发明涉及基因工程小鼠，衍生自这些小鼠的细胞，以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠，细胞，多核苷酸，多肽和抗体的方法。
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4.发明申请公开(公告)号：US20090193532A1
公开(公告)日：2009-07-30
申请号：US12099459
申请日：2008-04-08
申请人： Alejandro Abuin , Joel A. Edwards , Charles Montgomery , Carolina Rangel , Arthur T. Sands , Zheng-Zheng Shi , Mary Jean Sparks , Peter Vogel , Brian Zambrowicz
发明人： Alejandro Abuin , Joel A. Edwards , Charles Montgomery , Carolina Rangel , Arthur T. Sands , Zheng-Zheng Shi , Mary Jean Sparks , Peter Vogel , Brian Zambrowicz
IPC分类号： A01K67/027
CPC分类号： A01K67/0276 , A01K2217/075
摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.
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公开(公告)号：US06929937B2
公开(公告)日：2005-08-16
申请号：US10364774
申请日：2003-02-11
申请人： C. Alexander Turner, Jr. , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur T. Sands , D. Wade Walke , Nathaniel L. Wilganowski
发明人： C. Alexander Turner, Jr. , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur T. Sands , D. Wade Walke , Nathaniel L. Wilganowski
CPC分类号： C12N9/13 , A61K38/00 , C12N9/10 , C12N9/1051
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
摘要翻译： 公开了可用于治疗，诊断和药物基因组应用的新型人多核苷酸和多肽序列。
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公开(公告)号：US20080050809A1
公开(公告)日：2008-02-28
申请号：US11165424
申请日：2005-06-23
申请人： Alejandro Abuin , Gregory Donoho , Carl Johan Friddle , Glenn Friedrich , Brenda Gerhardt , Erin Hilbun , Yi Hu , James Alvin Kieke , Brian Mathur , Daniel Mathur , Maricar Miranda , Michael C. Nehls , Boris Nepomnichy , Arthur T. Sands , John Scoville , C. Alexander Turner , D. Wade Walke , Xiaoming Wang , Nathaniel L. Wilganowski , Amy Qiongshu Xie , Xuanchuan Yu , Brian Zambrowicz
发明人： Alejandro Abuin , Gregory Donoho , Carl Johan Friddle , Glenn Friedrich , Brenda Gerhardt , Erin Hilbun , Yi Hu , James Alvin Kieke , Brian Mathur , Daniel Mathur , Maricar Miranda , Michael C. Nehls , Boris Nepomnichy , Arthur T. Sands , John Scoville , C. Alexander Turner , D. Wade Walke , Xiaoming Wang , Nathaniel L. Wilganowski , Amy Qiongshu Xie , Xuanchuan Yu , Brian Zambrowicz
CPC分类号： C12N9/1205
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
摘要翻译： 公开了可用于治疗，诊断和药物基因组应用的新型人多核苷酸和多肽序列。
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公开(公告)号：US06806073B2
公开(公告)日：2004-10-19
申请号：US10446175
申请日：2003-05-27
申请人： Gregory Donoho , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Brian Zambrowicz , Alejandro Abuin , Arthur T. Sands
发明人： Gregory Donoho , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Brian Zambrowicz , Alejandro Abuin , Arthur T. Sands
IPC分类号： C12N912
CPC分类号： C12N9/1205 , A61K38/00
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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公开(公告)号：US06509456B2
公开(公告)日：2003-01-21
申请号：US09780016
申请日：2001-02-09
申请人： Gregory Donoho , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur T. Sands
发明人： Gregory Donoho , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur T. Sands
IPC分类号： C07H2104
CPC分类号： C07H21/04 , C12N9/6421
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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公开(公告)号：US06465632B1
公开(公告)日：2002-10-15
申请号：US09877730
申请日：2001-06-08
申请人： D. Wade Walke , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur T. Sands
发明人： D. Wade Walke , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur T. Sands
IPC分类号： C07H2104
CPC分类号： C07H21/04 , C07K14/70503 , C12N9/16
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
摘要翻译： 公开了可用于治疗，诊断和药物基因组应用的新型人多核苷酸和多肽序列。
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公开(公告)号：US06743621B2
公开(公告)日：2004-06-01
申请号：US10214811
申请日：2002-08-07
申请人： Gregory Donoho , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur T. Sands
发明人： Gregory Donoho , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur T. Sands
IPC分类号： C12N120
CPC分类号： C07H21/04 , C12N9/6421
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
摘要翻译： 公开了可用于治疗，诊断和药物基因组应用的新型人多核苷酸和多肽序列。
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