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1.Genetically Engineered and Photyped Mice and Stem Cell Clones for Producing the Same 审中-公开
Title translation: 基因工程和愚蠢的小鼠和干细胞克隆生产它公开(公告)号:US20090077680A1
公开(公告)日:2009-03-19
申请号:US12099465
申请日:2008-04-08
Applicant: Alejandro Abuin , Joel Edwards , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Zheng-Zheng Shi , Mary Jean Sparks , Teresa Gail Townsend , Rosemary Girgis , Allison Anne Byers Horner , Peter Vogel , Brian Zambrowicz
Inventor: Alejandro Abuin , Joel Edwards , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Zheng-Zheng Shi , Mary Jean Sparks , Teresa Gail Townsend , Rosemary Girgis , Allison Anne Byers Horner , Peter Vogel , Brian Zambrowicz
IPC: A01K67/027 , C12N5/06 , C07K16/18
CPC classification number: A01K67/0276 , A01K2217/054 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , C12N15/8509 , C12N2840/44
Abstract: The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.
Abstract translation: 本发明涉及基因工程小鼠,衍生自这些小鼠的细胞,以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠,细胞,多核苷酸,多肽和抗体的方法。
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2.Novel human membrane proteins and polynucleotides encoding the same 审中-公开
Title translation: 新型人膜蛋白和编码相同的多核苷酸公开(公告)号:US20070298489A1
公开(公告)日:2007-12-27
申请号:US11244415
申请日:2005-10-05
Applicant: Alejandro Abuin , Michael Burnett , Gregory Donoho , Carl Friddle , Glenn Friedrich , Brenda Gerhardt , Erin Hilbun , Yi Hu , Brian Mathur , Michael Nehls , Boris Nepomnichy , Arthur Sands , John Scoville , C. Turner , D. Walke , Xiaoming Wang , Frank Wattler , Nathaniel Wilganowski , Brian Zambrowicz
Inventor: Alejandro Abuin , Michael Burnett , Gregory Donoho , Carl Friddle , Glenn Friedrich , Brenda Gerhardt , Erin Hilbun , Yi Hu , Brian Mathur , Michael Nehls , Boris Nepomnichy , Arthur Sands , John Scoville , C. Turner , D. Walke , Xiaoming Wang , Frank Wattler , Nathaniel Wilganowski , Brian Zambrowicz
CPC classification number: C07K14/705
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Abstract translation: 公开了可用于治疗,诊断和药物基因组应用的新型人多核苷酸和多肽序列。
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公开(公告)号:US20060031947A1
公开(公告)日:2006-02-09
申请号:US11021492
申请日:2004-12-23
Applicant: Alejandro Abuin , Brian Zambrowicz , Arthur Sands
Inventor: Alejandro Abuin , Brian Zambrowicz , Arthur Sands
IPC: A01K67/00 , C07H21/04 , C12N5/06 , C12N15/867
CPC classification number: C12N15/873 , A01K2217/05 , C12N2799/027
Abstract: Novel mutated mammalian cells are provided that have been characterized by identifying the sequence of the genes that have been mutated. Preferably, novel mutated cells are murine ES cells that stably incorporate retroviral gene trap constructs in the specifically identified genes. The novel mutated cells and animals are useful in functional genomic analysis, and in the discovery and development of new therapeutic and diagnostics agents and methods.
Abstract translation: 提供了通过鉴定突变的基因的序列来表征的新型突变的哺乳动物细胞。 优选地,新的突变细胞是在特异性鉴定的基因中稳定并入逆转录病毒基因陷阱构建体的鼠ES细胞。 新型突变的细胞和动物在功能基因组分析中以及在发现和开发新的治疗和诊断试剂和方法中是有用的。
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4.Novel human transferase proteins and polynucleotides encoding the same 审中-公开
Title translation: 新的人转移酶蛋白和编码其的多核苷酸公开(公告)号:US20050287568A1
公开(公告)日:2005-12-29
申请号:US11134241
申请日:2005-05-20
Applicant: Gregory Donobo , Erin Hilbun , C. Turner , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur Sands , D. Walke , Nathaniel Wilganowski , Yi Hu , James Kieke , David Potter
Inventor: Gregory Donobo , Erin Hilbun , C. Turner , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur Sands , D. Walke , Nathaniel Wilganowski , Yi Hu , James Kieke , David Potter
CPC classification number: C12N9/13 , A61K38/00 , C12N9/10 , C12N9/1051
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Abstract translation: 公开了可用于治疗,诊断和药物基因组应用的新型人多核苷酸和多肽序列。
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5.Human transferase proteins and polynucleotides encoding the same 失效
Title translation: 人转移酶蛋白和编码其的多核苷酸公开(公告)号:US06929937B2
公开(公告)日:2005-08-16
申请号:US10364774
申请日:2003-02-11
Applicant: C. Alexander Turner, Jr. , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur T. Sands , D. Wade Walke , Nathaniel L. Wilganowski
Inventor: C. Alexander Turner, Jr. , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur T. Sands , D. Wade Walke , Nathaniel L. Wilganowski
CPC classification number: C12N9/13 , A61K38/00 , C12N9/10 , C12N9/1051
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Abstract translation: 公开了可用于治疗,诊断和药物基因组应用的新型人多核苷酸和多肽序列。
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6.
公开(公告)号:US20080050809A1
公开(公告)日:2008-02-28
申请号:US11165424
申请日:2005-06-23
Applicant: Alejandro Abuin , Gregory Donoho , Carl Johan Friddle , Glenn Friedrich , Brenda Gerhardt , Erin Hilbun , Yi Hu , James Alvin Kieke , Brian Mathur , Daniel Mathur , Maricar Miranda , Michael C. Nehls , Boris Nepomnichy , Arthur T. Sands , John Scoville , C. Alexander Turner , D. Wade Walke , Xiaoming Wang , Nathaniel L. Wilganowski , Amy Qiongshu Xie , Xuanchuan Yu , Brian Zambrowicz
Inventor: Alejandro Abuin , Gregory Donoho , Carl Johan Friddle , Glenn Friedrich , Brenda Gerhardt , Erin Hilbun , Yi Hu , James Alvin Kieke , Brian Mathur , Daniel Mathur , Maricar Miranda , Michael C. Nehls , Boris Nepomnichy , Arthur T. Sands , John Scoville , C. Alexander Turner , D. Wade Walke , Xiaoming Wang , Nathaniel L. Wilganowski , Amy Qiongshu Xie , Xuanchuan Yu , Brian Zambrowicz
CPC classification number: C12N9/1205
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Abstract translation: 公开了可用于治疗,诊断和药物基因组应用的新型人多核苷酸和多肽序列。
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公开(公告)号:US20050214783A1
公开(公告)日:2005-09-29
申请号:US10889890
申请日:2004-07-12
Applicant: D. Walke , C. Turner , Alejandro Abuin , Glenn Friedrich , Brian Zambrowicz , Arthur Sands
Inventor: D. Walke , C. Turner , Alejandro Abuin , Glenn Friedrich , Brian Zambrowicz , Arthur Sands
CPC classification number: C12N9/6424
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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8.
公开(公告)号:US20050009087A1
公开(公告)日:2005-01-13
申请号:US10920089
申请日:2004-08-16
Applicant: Gregory Donoho , Erin Hilbun , John Scoville , C. Turner , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur Sands
Inventor: Gregory Donoho , Erin Hilbun , John Scoville , C. Turner , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur Sands
CPC classification number: C12N9/78
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Abstract translation: 公开了可用于治疗,诊断和药物基因组应用的新型人多核苷酸和多肽序列。
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公开(公告)号:US06806073B2
公开(公告)日:2004-10-19
申请号:US10446175
申请日:2003-05-27
Applicant: Gregory Donoho , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Brian Zambrowicz , Alejandro Abuin , Arthur T. Sands
Inventor: Gregory Donoho , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Brian Zambrowicz , Alejandro Abuin , Arthur T. Sands
IPC: C12N912
CPC classification number: C12N9/1205 , A61K38/00
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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公开(公告)号:US06509456B2
公开(公告)日:2003-01-21
申请号:US09780016
申请日:2001-02-09
Applicant: Gregory Donoho , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur T. Sands
Inventor: Gregory Donoho , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Alejandro Abuin , Brian Zambrowicz , Arthur T. Sands
IPC: C07H2104
CPC classification number: C07H21/04 , C12N9/6421
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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