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公开(公告)号：US09314460B1
公开(公告)日：2016-04-19
申请号：US14249150
申请日：2014-04-09
IPC分类号： C07D309/00 , A61K31/47 , A61K31/122 , G01N33/50 , A61K31/4425 , A61K31/357 , A61K31/343 , A61K31/35 , A61K31/437
CPC分类号： A61K31/58 , A61K31/00 , A61K31/122 , A61K31/343 , A61K31/35 , A61K31/357 , A61K31/365 , A61K31/437 , A61K31/4425 , A61K31/47 , A61K45/06 , G01N33/5011 , G01N2500/10 , G01N2800/52
摘要： In one embodiment, the invention provides a method of inhibiting cAMP efflux and increasing intracellular cAMP in a subject who suffers from, or who is at risk of developing, a cancer by administering to the subject a therapeutically-effective amount of a cAMP efflux inhibitor. Novel compounds, pharmaceutical compositions, diagnostics and screening methods are also provided.
摘要翻译： 在一个实施方案中，本发明提供了通过向受试者施用治疗有效量的cAMP外排抑制剂来抑制患有或有风险发展为癌症的受试者的cAMP外排和增加细胞内cAMP的方法。 还提供了新颖的化合物，药物组合物，诊断和筛选方法。
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公开(公告)号：US20130005782A1
公开(公告)日：2013-01-03
申请号：US13583068
申请日：2011-03-23
申请人： Alexandre Chigaev , Larry A. Sklar
发明人： Alexandre Chigaev , Larry A. Sklar
IPC分类号： G01N33/566 , G01N33/577 , G01N21/64 , A61K31/197 , C07C233/63 , A61K31/42 , C07D261/18 , A61K31/36 , C07D317/68 , A61P25/00 , A61P21/04 , A61P27/02 , A61P7/00 , A61P7/06 , A61P9/00 , A61P19/02 , A61P29/00 , A61P17/00 , A61P19/04 , A61P19/00 , A61P1/00 , A61P1/16 , A61P1/04 , A61P3/10 , A61P5/00 , A61P17/06 , A61P11/06 , A61P11/00 , A61P37/00 , A61P9/10 , A61P13/12 , A61P37/06 , A61P17/12 , A61P35/00 , A61P35/04 , C40B30/04
CPC分类号： G01N33/5041 , A61K31/195 , A61K31/197 , A61K31/357 , A61K31/36 , A61K31/42 , G01N33/5055 , G01N33/68 , G01N2333/70546 , G01N2333/7055 , G01N2500/04 , G01N2500/10
摘要： This invention relates generally to integrin ligand discovery and to a method of integrin ligand discovery base upon induction of ligand-induced epitopes. Such ligands have the potential to be active agent as anti-inflammatory, anti-angiogenesis and/or anti-thrombotic agents and for the treatment of integrin mediated diseases and/or conditions.
摘要翻译： 本发明一般涉及整合素配体发现和基于诱导配体诱导表位的整联蛋白配体发现的方法。 这样的配体具有作为抗炎，抗血管生成和/或抗血栓形成剂的活性剂的潜力，并且用于治疗整联蛋白介导的疾病和/或病症。
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公开(公告)号：US08911952B2
公开(公告)日：2014-12-16
申请号：US13583068
申请日：2011-03-23
申请人： Alexandre Chigaev , Larry A. Sklar
发明人： Alexandre Chigaev , Larry A. Sklar
IPC分类号： G01N33/53 , G01N33/68 , A61K31/36 , A61K31/42 , A61K31/195
CPC分类号： G01N33/5041 , A61K31/195 , A61K31/197 , A61K31/357 , A61K31/36 , A61K31/42 , G01N33/5055 , G01N33/68 , G01N2333/70546 , G01N2333/7055 , G01N2500/04 , G01N2500/10
摘要： This invention relates generally to integrin ligand discovery and to a method of integrin ligand discovery base upon induction of ligand-induced epitopes. Such ligands have the potential to be active agent as anti-inflammatory, anti-angiogenesis and/or anti-thrombotic agents and for the treatment of integrin mediated diseases and/or conditions.
摘要翻译： 本发明一般涉及整合素配体发现和基于诱导配体诱导表位的整联蛋白配体发现的方法。 这样的配体具有作为抗炎，抗血管生成和/或抗血栓形成剂的活性剂的潜力，并且用于治疗整联蛋白介导的疾病和/或病症。
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