公开(公告)号：US20130273024A1

公开(公告)日：2013-10-17

申请号：US13851019

申请日：2013-03-26

Applicant: Amgen Inc.

Inventor： Frank KAYSER ,  Marc Labelle ,  Bei Shan ,  Jian Zhang ,  Mingyue Zhou

IPC: C12N9/10 ,  C07D403/12 ,  C07D417/12

CPC classification number: C12N9/1029 ,  A61K31/497 ,  A61K38/45 ,  C07D403/12 ,  C07D417/12

Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, inflammation, thrombosis and other conditions and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.

Abstract translation: 本发明提供了通过改变LCAT多肽来治疗动脉粥样硬化，炎症，血栓形成和其它病症并降低或预防受试者胆固醇积聚的化合物，药物组合物和方法。