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1.发明申请Novel heteroaryl-substituted arylaminopyridine derivatives as MEK inhibitors 有权新的杂芳基取代的芳基氨基吡啶衍生物作为MEK抑制剂公开(公告)号：US20070287737A1
公开(公告)日：2007-12-13
申请号：US11788032
申请日：2007-04-18
申请人： Andreas Goutopoulos , Benny Askew , Xiaoling Chen , Srinivasa Karra , Yufang Xiao , Henry Yu
发明人： Andreas Goutopoulos , Benny Askew , Xiaoling Chen , Srinivasa Karra , Yufang Xiao , Henry Yu
IPC分类号： A61K31/44 , A61P35/00 , C07D401/00 , C07D417/00
CPC分类号： C07D213/79 , C07D213/81 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The invention provides novel heteroaryl-substituted arylaminopyridine derivative MEK inhibitors of Formula (Ia) Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供式（Ia）的新型杂芳基取代的芳基氨基吡啶衍生物MEK抑制剂。这些化合物是可用于治疗过度增殖性疾病如癌症和炎症的MEK抑制剂。 还公开了哺乳动物中过度增殖性疾病的治疗，以及含有这些化合物的药物组合物。
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公开(公告)号：US20070287709A1
公开(公告)日：2007-12-13
申请号：US11788028
申请日：2007-04-18
申请人： Andreas Goutopoulos , Benny Askew , Nhut Diep , Srinivasa Karra , Matthias Schwarz , Henry Yu
发明人： Andreas Goutopoulos , Benny Askew , Nhut Diep , Srinivasa Karra , Matthias Schwarz , Henry Yu
IPC分类号： A61K31/44 , A61K31/50 , A61K31/535 , A61P43/00 , C07D211/70 , C07D211/72 , C07D237/02 , C07D401/00
CPC分类号： C07D213/84 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D237/24 , C07D405/12
摘要： The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供式（I）的新的芳基氨基N-杂芳基MEK抑制剂：这些化合物是可用于治疗过度增殖性疾病如癌症和炎症的MEK抑制剂。 还公开了哺乳动物中过度增殖性疾病的治疗，以及含有这些化合物的药物组合物。
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3.发明授权公开(公告)号：US08076486B2
公开(公告)日：2011-12-13
申请号：US11788032
申请日：2007-04-18
IPC分类号： C07D417/00 , C07D413/04 , C07D401/00
CPC分类号： C07D213/79 , C07D213/81 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The invention provides novel heteroaryl-substituted arylaminopyridine derivative MEK inhibitors of Formula (Ia) Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供式（Ia）的新型杂芳基取代的芳基氨基吡啶衍生物MEK抑制剂。这些化合物是可用于治疗过度增殖性疾病如癌症和炎症的MEK抑制剂。 还公开了哺乳动物中过度增殖性疾病的治疗，以及含有这些化合物的药物组合物。
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公开(公告)号：US20140107156A1
公开(公告)日：2014-04-17
申请号：US14105974
申请日：2013-12-13
申请人： Amanda E. Sutton , Thomas E. Richardson , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Andreas Goutopoulos , Ruoxi Lan , David Perrey , Harold George Vandeveer , Lesley Liu-Bujalski , Frank Steiber , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
发明人： Amanda E. Sutton , Thomas E. Richardson , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Andreas Goutopoulos , Ruoxi Lan , David Perrey , Harold George Vandeveer , Lesley Liu-Bujalski , Frank Steiber , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
IPC分类号： C07D215/04 , A61K31/47
CPC分类号： C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要： The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供根据式（I）的新型取代的氨基氮杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号：US08637532B2
公开(公告)日：2014-01-28
申请号：US13148903
申请日：2010-02-04
申请人： Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
发明人： Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要： The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供根据式（I）的新型取代的氨基氮杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号：US08735584B2
公开(公告)日：2014-05-27
申请号：US12919136
申请日：2009-02-25
申请人： Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
发明人： Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
IPC分类号： C07D471/04 , C07D471/06
CPC分类号： C07D471/04
摘要： Disclosed are benzonaphthyridinyl derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to kinase signal transduction inhibition, regulation or modulation.
摘要翻译： 公开了苯并萘并吡啶基衍生物化合物及其类似物，包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗适于激酶信号转导抑制，调节或调节的疾病。
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公开(公告)号：US20110269758A1
公开(公告)日：2011-11-03
申请号：US12997312
申请日：2009-06-29
申请人： Yufang Xiao , Bayard R. Huck , Amanda E. Sutton , Xiaoling Chen , Srinivasa R. Karra , Andreas Goutopoulos
发明人： Yufang Xiao , Bayard R. Huck , Amanda E. Sutton , Xiaoling Chen , Srinivasa R. Karra , Andreas Goutopoulos
IPC分类号： A61K31/5377 , A61K31/4375 , A61K31/519 , C07D413/14 , A61P37/06 , A61P17/06 , A61P9/10 , A61P31/04 , A61P31/12 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04 , A61K31/436 , A61K45/06 , A61K2300/00
摘要： Naphthyridinone derivative compounds that inhibit Aurora kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative diseases resulting from unregulated and/or disturbed Aurora kinases such as cancers, psoriasis, viral and bacterial infections, inflammatory and autoimmune diseases.
摘要翻译： 公开了抑制极光激酶的萘吡啶酮衍生物化合物以及包含这些化合物的药物组合物及其合成方法。 这些化合物可用于治疗由不规则和/或扰乱的极光激酶如癌症，牛皮癣，病毒和细菌感染，炎性和自身免疫性疾病引起的增殖性疾病。
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公开(公告)号：US20110053906A1
公开(公告)日：2011-03-03
申请号：US12919136
申请日：2009-02-25
申请人： Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
发明人： Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
IPC分类号： A61K31/4745 , C07D471/04 , A61K31/5377 , A61K31/496 , A61K31/536 , A61P35/00
CPC分类号： C07D471/04
摘要： Disclosed are benzonaphthyridinyl derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to kinase signal transduction inhibition, regulation or modulation.
摘要翻译： 公开了苯并萘并吡啶基衍生物化合物及其类似物，包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗适于激酶信号转导抑制，调节或调节的疾病。
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公开(公告)号：US07772233B2
公开(公告)日：2010-08-10
申请号：US11788028
申请日：2007-04-18
申请人： Andreas Goutopoulos , Benny C. Askew, Jr. , Nhut Kiet Diep , Srinivasa Karra , Matthias Schwarz , Henry Yu
发明人： Andreas Goutopoulos , Benny C. Askew, Jr. , Nhut Kiet Diep , Srinivasa Karra , Matthias Schwarz , Henry Yu
IPC分类号： C07D237/12 , C07D413/04 , A61K31/50 , A61K31/5355 , A61P35/00 , A61P29/00 , C07D213/74 , C07D405/12 , C07D213/57
CPC分类号： C07D213/84 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D237/24 , C07D405/12
摘要： The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供式（I）的新的芳基氨基N-杂芳基MEK抑制剂：这些化合物是可用于治疗过度增殖性疾病如癌症和炎症的MEK抑制剂。 还公开了哺乳动物中过度增殖性疾病的治疗，以及含有这些化合物的药物组合物。
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10.发明申请公开(公告)号：US20100256149A1
公开(公告)日：2010-10-07
申请号：US12815071
申请日：2010-06-14
申请人： Andreas Goutopoulos , Benny C. Askew, JR. , Nhut Kiet Diep , Srinivasa Karra , Matthias Schwarz , Henry Yu
发明人： Andreas Goutopoulos , Benny C. Askew, JR. , Nhut Kiet Diep , Srinivasa Karra , Matthias Schwarz , Henry Yu
IPC分类号： A61K31/5377 , C07D213/90 , A61K31/44 , A61K31/455 , C07D237/24 , A61K31/50 , C07D413/04 , C07D403/12 , A61K31/501 , A61P29/00 , A61P35/00
CPC分类号： C07D213/84 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D237/24 , C07D405/12
摘要： The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供式（I）的新的芳基氨基N-杂芳基MEK抑制剂：这些化合物是可用于治疗过度增殖性疾病如癌症和炎症的MEK抑制剂。 还公开了哺乳动物中过度增殖性疾病的治疗，以及含有这些化合物的药物组合物。
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