-
1.发明申请公开(公告)号：US20100256149A1
公开(公告)日：2010-10-07
申请号：US12815071
申请日：2010-06-14
申请人： Andreas Goutopoulos , Benny C. Askew, JR. , Nhut Kiet Diep , Srinivasa Karra , Matthias Schwarz , Henry Yu
发明人： Andreas Goutopoulos , Benny C. Askew, JR. , Nhut Kiet Diep , Srinivasa Karra , Matthias Schwarz , Henry Yu
IPC分类号： A61K31/5377 , C07D213/90 , A61K31/44 , A61K31/455 , C07D237/24 , A61K31/50 , C07D413/04 , C07D403/12 , A61K31/501 , A61P29/00 , A61P35/00
CPC分类号： C07D213/84 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D237/24 , C07D405/12
摘要： The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供式（I）的新的芳基氨基N-杂芳基MEK抑制剂：这些化合物是可用于治疗过度增殖性疾病如癌症和炎症的MEK抑制剂。 还公开了哺乳动物中过度增殖性疾病的治疗，以及含有这些化合物的药物组合物。
-
公开(公告)号：US20130184314A1
公开(公告)日：2013-07-18
申请号：US13785120
申请日：2013-03-05
IPC分类号： C07D213/82
CPC分类号： C07D213/82 , C07D213/79 , C07D213/81
摘要： The invention provides novel compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation.
摘要翻译： 本发明提供根据式（I）的新化合物，其用于治疗过度增生性疾病如癌症，再狭窄和炎症的制备和用途。
-
公开(公告)号：US20090137452A1
公开(公告)日：2009-05-28
申请号：US12082219
申请日：2008-04-08
申请人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
发明人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
摘要： The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a multivalent vehicle, including peptides conjugated to multivalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.
摘要翻译： 本发明涉及涉及与多价载体缀合的缓激肽B1受体拮抗剂肽的物质组合物，包括与多价PEG缀合的肽。 这些组合物可用作与缓激肽B1受体连接的疾病或病症例如炎症或疼痛的治疗剂或预防剂。
-
公开(公告)号：US20090048149A1
公开(公告)日：2009-02-19
申请号：US12082395
申请日：2008-04-09
申请人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
发明人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
摘要： The present invention relates to a method of treating, preventing, or ameliorating a disease or condition associated with or mediated by B1 activity that involves administering a composition of matter containing bradykinin B1 receptor antagonist peptides conjugated to a multivalent vehicle, including peptides conjugated to multivalent PEG. The method can be used therapeutically or prophylactically against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.
摘要翻译： 本发明涉及一种治疗，预防或改善与B1活性相关或介导的疾病或病症的方法，该方法包括给予包含与多价载体缀合的缓激肽B1受体拮抗剂肽的物质组合物，包括与多价PEG缀合的肽 。 该方法可以治疗性或预防性地用于与缓激肽B1受体连接的疾病或病症，例如炎症或疼痛。
-
公开(公告)号：US20090048224A1
公开(公告)日：2009-02-19
申请号：US12205616
申请日：2008-09-05
申请人： Robert D. Groneberg , Benny C. Askew, JR. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
发明人： Robert D. Groneberg , Benny C. Askew, JR. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
IPC分类号： A61K31/397 , A61K31/453 , C07D401/02 , C07D405/02 , A61K31/496 , A61K31/4545 , C07D407/02 , A61K31/4025 , A61K31/351 , A61P27/02 , A61P27/06 , A61P11/06 , A61P9/00 , A61P19/02 , A61P25/28 , A61K31/4375 , C07D471/04 , C07D205/04 , A61P3/10 , C07D311/02 , C07D413/02 , A61K31/5377 , A61K31/5415 , C07D279/02 , C07C311/01 , A61K31/18
CPC分类号： C07C311/19 , C07C311/13 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/20 , C07D209/14 , C07D209/16 , C07D209/40 , C07D209/52 , C07D211/38 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/70 , C07D213/42 , C07D213/56 , C07D213/64 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/22 , C07D233/54 , C07D239/74 , C07D271/08 , C07D277/64 , C07D279/02 , C07D285/14 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/14 , C07D307/28 , C07D307/79 , C07D307/81 , C07D311/68 , C07D317/58 , C07D333/20 , C07D333/24 , C07D333/58 , C07D333/62 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/08
摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号：US20120022060A1
公开(公告)日：2012-01-26
申请号：US13140357
申请日：2009-12-03
申请人： Bayard R. Huck , Amanda E. Sutton , Benny C. Askew, JR. , Christopher Charles Victor Jones , Garry R. Smith , Nadia Brugger
发明人： Bayard R. Huck , Amanda E. Sutton , Benny C. Askew, JR. , Christopher Charles Victor Jones , Garry R. Smith , Nadia Brugger
IPC分类号： A61K31/5377 , C07D413/14 , C07D401/14 , A61P19/10 , A61K31/497 , A61P35/00 , A61P9/10 , C07D471/14 , A61K31/4375
CPC分类号： C07D471/04
摘要： Disclosed are dipyridyl-pyrrole derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation.
摘要翻译： 公开了联吡啶基 - 吡咯衍生物化合物及其类似物，包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗适于蛋白激酶信号转导抑制，调节和/或调节的疾病。
-
公开(公告)号：US20090143355A1
公开(公告)日：2009-06-04
申请号：US12322361
申请日：2009-01-29
申请人： Chester Chenguang Yuan , Kevin Yang , Simon Van Der Plas , Babak Riahi , Michele Potashman , Vinod F. Patel , Rana Nomak , Aiwen Li , Qi Huang , Jean-Christophe Harmange , Benny C. Askew, JR.
发明人： Chester Chenguang Yuan , Kevin Yang , Simon Van Der Plas , Babak Riahi , Michele Potashman , Vinod F. Patel , Rana Nomak , Aiwen Li , Qi Huang , Jean-Christophe Harmange , Benny C. Askew, JR.
IPC分类号： A61K31/517 , C07D401/02 , A61P35/00 , C07D413/14 , A61K31/4725 , A61K31/496 , C07D401/14
CPC分类号： C07D401/12 , C07D217/02 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds of Formula I and II wherein R, R1 and R2 for each formula are defined herein. The invention further includes analogs, prodrugs and pharmaceutically acceptable salts and derivatives of Formulas I and II, as well as pharmaceutical compositions, medicaments and methods thereof for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
-
公开(公告)号：US20090137483A1
公开(公告)日：2009-05-28
申请号：US12082224
申请日：2008-04-08
申请人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
发明人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
摘要： The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a univalent vehicle, including peptides conjugated to univalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.
摘要翻译： 本发明涉及与单价载体缀合的缓激肽B1受体拮抗剂肽的物质组合物，包括与一价PEG缀合的肽。 这些组合物可用作与缓激肽B1受体连接的疾病或病症例如炎症或疼痛的治疗剂或预防剂。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.031 秒)
