公开(公告)号：US09242964B2

公开(公告)日：2016-01-26

申请号：US14016951

申请日：2013-09-03

Applicant: VentiRx Pharmaceuticals, Inc. ,  Array BioPharma, Inc.

Inventor： James Jeffry Howbert ,  Gregory Dietsch ,  Robert M. Hershberg ,  Laurence E. Burgess ,  George A. Doherty ,  C. Todd Eary ,  Robert D. Groneberg ,  Zachary Jones

IPC: A61K31/55 ,  C07D223/16 ,  C07D403/14 ,  A61K31/4025 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D401/14

CPC classification number: C07D223/16 ,  A61K31/4025 ,  A61K31/55 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/14

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

公开(公告)号：US20140228349A1

公开(公告)日：2014-08-14

申请号：US14351415

申请日：2012-10-09

Applicant: Array BioPharma Inc.

Inventor： Mark Laurence Boys ,  Laurence E. Burgess ,  C. Todd Eary ,  Robert Groneberg ,  Bruno P. Hache ,  Darren Harvey ,  Erik James Hicken ,  Christopher F. Kraser ,  Ellen Laird ,  David A. Moreno ,  Mark C. Munson ,  Li Ren ,  John E. Robinson ,  Stephen T. Schlachter

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

Abstract translation: R 1，R 2，R 3，R 4，R 5，R 6，X 1和X 2具有本说明书中给出的含义的式I化合物及其立体异构体及其药学上可接受的盐和溶剂化物是一种或多种JAK激酶的抑制剂，并且是有用的 治疗自身免疫性疾病，炎症性疾病，移植器官，组织和细胞排斥，以及血液系统疾病和恶性肿瘤及其并发症。

公开(公告)号：US09790206B2

公开(公告)日：2017-10-17

申请号：US14770035

申请日：2014-02-27

Applicant: Array BioPharma Inc.

Inventor： C. Todd Eary ,  Bruno P. Hache ,  Derrick Juengst ,  Stacey Renee Spencer ,  Peter J. Stengel ,  Daniel John Watson

IPC: C07D403/12 ,  C07D231/56

CPC classification number: C07D403/12 ,  C07D231/56

Abstract: Provided herein are novel processes for preparing a compound of Formula (I) to the use of said compound as an intermediate in novel processes for the synthesis of indazole derivatives, and to indazole intermediates and derivatives prepared by the processes described herein.

公开(公告)号：US20140142086A1

公开(公告)日：2014-05-22

申请号：US14016951

申请日：2013-09-03

Applicant: ARRAY BIOPHARMA, INC. ,  VENTIRX PHARMACEUTICALS, INC.

Inventor： James Jeffry Howbert ,  Gregory Dietsch ,  Robert M. Hershberg ,  Laurence E. Burgess ,  George A. Doherty ,  C. Todd Eary ,  Robert D. Groneberg ,  Zachary Jones

IPC: C07D403/14 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D401/14

CPC classification number: C07D223/16 ,  A61K31/4025 ,  A61K31/55 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/14

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.