利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

2 条记录 (耗时 0.013 秒)

    TETRAHYDROBENZOTHIOPHENE COMPOUND
    2.
    发明申请
    TETRAHYDROBENZOTHIOPHENE COMPOUND 有权
    四氢苯并噻唑化合物

    公开(公告)号：US20140329802A1

    公开(公告)日：2014-11-06

    申请号：US14229146

    申请日：2014-03-28

    申请人： Astellas Pharma Inc.

    发明人： Shunichiro HACHIYA ,  Masanori Miura ,  Yoshimasa Imamura ,  Daisuke Kaga ,  Ippei Sato ,  Hiroyuki Moritomo ,  Koji Kato ,  Kazuhiro Terai ,  Yoh Terada

    IPC分类号： C07D333/66 ,  C07D409/12

    CPC分类号： C07D333/66 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/63 ,  A61K31/7042 ,  C07D333/68 ,  C07D409/12

    摘要： The purpose is to provide a compound which has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia.A tetrahydrobenzothiophene compound of the following formula (I) has NPT-IIb inhibitory action and can be used as an agent for treating and/or preventing hyperphosphatemia: wherein, R1 represents —O-lower alkyl, -lower alkylene-phenyl, or the like; R2 and R3 are the same as or different from each other and represent H, lower alkyl, cycloalkyl, aryl, heteroaryl or the like, or, R2 and R3 may be combined with a nitrogen atom to which they bind to form 5- to 7-membered saturated cyclic amino; R4's are the same as or different from each other and represent halogen, lower alkyl; and n represents 0 to 2.

    摘要翻译： 目的是提供具有肠道磷酸转运蛋白（NPT-IIb）抑制作用的化合物，并且可用作治疗和/或预防高磷酸血症的药剂的活性成分。 下式（I）的四氢苯并噻吩化合物具有NPT-IIb抑制作用，可用作治疗和/或预防高磷酸血症的药剂：其中，R1表示-O-低级烷基， - 低级亚烷基 - 苯基等 ; R2和R3彼此相同或不同，表示H，低级烷基，环烷基，芳基，杂芳基等，或者R2和R3可以与它们结合的氮原子结合形成5-至7 饱和环状氨基; R 4彼此相同或不同，表示卤素，低级烷基; n表示0〜2。