TETRAHYDROBENZOTHIOPHENE COMPOUND
    2.
    发明申请
    TETRAHYDROBENZOTHIOPHENE COMPOUND 有权
    四氢苯并噻唑化合物

    公开(公告)号:US20140329802A1

    公开(公告)日:2014-11-06

    申请号:US14229146

    申请日:2014-03-28

    IPC分类号: C07D333/66 C07D409/12

    摘要: The purpose is to provide a compound which has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia.A tetrahydrobenzothiophene compound of the following formula (I) has NPT-IIb inhibitory action and can be used as an agent for treating and/or preventing hyperphosphatemia: wherein, R1 represents —O-lower alkyl, -lower alkylene-phenyl, or the like; R2 and R3 are the same as or different from each other and represent H, lower alkyl, cycloalkyl, aryl, heteroaryl or the like, or, R2 and R3 may be combined with a nitrogen atom to which they bind to form 5- to 7-membered saturated cyclic amino; R4's are the same as or different from each other and represent halogen, lower alkyl; and n represents 0 to 2.

    摘要翻译: 目的是提供具有肠道磷酸转运蛋白(NPT-IIb)抑制作用的化合物,并且可用作治疗和/或预防高磷酸血症的药剂的活性成分。 下式(I)的四氢苯并噻吩化合物具有NPT-IIb抑制作用,可用作治疗和/或预防高磷酸血症的药剂:其中,R1表示-O-低级烷基, - 低级亚烷基 - 苯基等 ; R2和R3彼此相同或不同,表示H,低级烷基,环烷基,芳基,杂芳基等,或者R2和R3可以与它们结合的氮原子结合形成5-至7 饱和环状氨基; R 4彼此相同或不同,表示卤素,低级烷基; n表示0〜2。