利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.023 秒)

    Imidazopyridine compounds
    3.
    发明授权
    Imidazopyridine compounds 有权
    咪唑并吡啶化合物

    公开(公告)号：US09447090B2

    公开(公告)日：2016-09-20

    申请号：US14090074

    申请日：2013-11-26

    申请人： Astellas Pharma Inc.

    发明人： Yuji Koga ,  Kyoichi Maeno ,  Ippei Sato ,  Yoshimasa Imamura ,  Takeshi Hanazawa ,  Maiko Iida ,  Kazuhiko Ohne ,  Kenichiro Imamura ,  Tsubasa Watanabe ,  Eisuke Nozawa ,  Hiroshi Shibata

    IPC分类号： C07D471/04 ,  C07D453/02 ,  C07D519/00

    CPC分类号： C07D471/04 ,  C07D453/02 ,  C07D519/00

    摘要： An excellent drug for treating or preventing cardiovascular diseases, based on cGMP production enhancing action due to soluble guanylate cyclase activating action, is provided. It was found that imidazopyridine compounds having a carbamoyl group at the 3-position and a substituent bonded at the 8-position via an oxygen atom in an imidazo[1,2-a]pyridine skeleton exhibits a cGMP production enhancing action by a potent soluble guanylate cyclase activating action, and is useful as a drug for treating or preventing various soluble guanylate cyclase-related cardiovascular diseases, thereby completing the present invention.

    摘要翻译： 提供了一种用于治疗或预防心血管疾病的优异药物，其基于由可溶性鸟苷酸环化酶激活作用引起的cGMP产生增强作用。 发现在咪唑并[1,2-a]吡啶骨架中3-位具有氨基甲酰基和8-位上通过氧原子键合的取代基的咪唑并吡啶化合物通过有效的可溶性表现出cGMP产生增强作用 鸟苷酸环化酶激活作用，可用作治疗或预防各种可溶性鸟苷酸环化酶相关心血管疾病的药物，从而完成本发明。

    TETRAHYDROBENZOTHIOPHENE COMPOUND
    4.
    发明申请
    TETRAHYDROBENZOTHIOPHENE COMPOUND 有权
    四氢苯并噻唑化合物

    公开(公告)号：US20140329802A1

    公开(公告)日：2014-11-06

    申请号：US14229146

    申请日：2014-03-28

    申请人： Astellas Pharma Inc.

    发明人： Shunichiro HACHIYA ,  Masanori Miura ,  Yoshimasa Imamura ,  Daisuke Kaga ,  Ippei Sato ,  Hiroyuki Moritomo ,  Koji Kato ,  Kazuhiro Terai ,  Yoh Terada

    IPC分类号： C07D333/66 ,  C07D409/12

    CPC分类号： C07D333/66 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/63 ,  A61K31/7042 ,  C07D333/68 ,  C07D409/12

    摘要： The purpose is to provide a compound which has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia.A tetrahydrobenzothiophene compound of the following formula (I) has NPT-IIb inhibitory action and can be used as an agent for treating and/or preventing hyperphosphatemia: wherein, R1 represents —O-lower alkyl, -lower alkylene-phenyl, or the like; R2 and R3 are the same as or different from each other and represent H, lower alkyl, cycloalkyl, aryl, heteroaryl or the like, or, R2 and R3 may be combined with a nitrogen atom to which they bind to form 5- to 7-membered saturated cyclic amino; R4's are the same as or different from each other and represent halogen, lower alkyl; and n represents 0 to 2.

    摘要翻译： 目的是提供具有肠道磷酸转运蛋白（NPT-IIb）抑制作用的化合物，并且可用作治疗和/或预防高磷酸血症的药剂的活性成分。 下式（I）的四氢苯并噻吩化合物具有NPT-IIb抑制作用，可用作治疗和/或预防高磷酸血症的药剂：其中，R1表示-O-低级烷基， - 低级亚烷基 - 苯基等 ; R2和R3彼此相同或不同，表示H，低级烷基，环烷基，芳基，杂芳基等，或者R2和R3可以与它们结合的氮原子结合形成5-至7 饱和环状氨基; R 4彼此相同或不同，表示卤素，低级烷基; n表示0〜2。

    Tetrahydrobenzothiophene compound
    5.
    发明授权
    Tetrahydrobenzothiophene compound 有权
    四氢苯并噻吩化合物

    公开(公告)号：US08729068B2

    公开(公告)日：2014-05-20

    申请号：US13661545

    申请日：2012-10-26

    申请人： Astellas Pharma Inc.

    发明人： Shunichiro Hachiya ,  Masanori Miura ,  Yoshimasa Imamura ,  Daisuke Kaga ,  Ippei Sato ,  Hiroyuki Moritomo ,  Koji Kato ,  Kazuhiro Terai ,  Yoh Terada

    IPC分类号： C07D333/68 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4436

    CPC分类号： C07D333/66 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/63 ,  A61K31/7042 ,  C07D333/68 ,  C07D409/12

    摘要： The purpose is to provide a compound which has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia.A tetrahydrobenzothiophene compound of the following formula (I) has NPT-IIb inhibitory action and can be used as an agent for treating and/or preventing hyperphosphatemia: wherein, R1 represents —O-lower alkyl, -lower alkylene-phenyl, or the like; R2 and R3 are the same as or different from each other and represent H, lower alkyl, cycloalkyl, aryl, heteroaryl or the like, or, R2 and R3 may be combined with a nitrogen atom to which they bind to form 5- to 7-membered saturated cyclic amino; R4's are the same as or different from each other and represent halogen, lower alkyl; and n represents 0 to 2.

    摘要翻译： 目的是提供具有肠道磷酸转运蛋白（NPT-IIb）抑制作用的化合物，并且可用作治疗和/或预防高磷酸血症的药剂的活性成分。 下式（I）的四氢苯并噻吩化合物具有NPT-IIb抑制作用，可用作治疗和/或预防高磷酸血症的药剂：其中，R1表示-O-低级烷基， - 低级亚烷基 - 苯基等 ; R2和R3彼此相同或不同，表示H，低级烷基，环烷基，芳基，杂芳基等，或者R2和R3可以与它们结合的氮原子结合形成5-至7 饱和环状氨基; R 4彼此相同或不同，表示卤素，低级烷基; n表示0〜2。