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公开(公告)号：US20160168143A1
公开(公告)日：2016-06-16
申请号：US14907148
申请日：2014-07-22
Applicant: BASF SE
Inventor： Andreas HAFNER , Fritz BLATTER , Martin SZELAGIEWICZ , Bernd SIEBENHAAR , Tiziana CHIODO , Tobias HINTERMANN , Beate SALVADOR , Marcus VOSSEN
IPC: C07D417/12 , C07D275/06
CPC classification number: C07D417/12 , C07B2200/13 , C07D275/06
Abstract: The present invention primarily relates to molecular crystalline substances, preferably salts of Dasatinib in crystalline form, comprising a compound of formula 1, preferably a cation of a compound of formula 1, and a second compound selected from the group consisting of glutaric acid, nicotinic acid and saccharin, preferably an anion thereof. The Invention is further related to pharmaceutical compositions comprising such a substance. Furthermore, the Invention relates to processes for preparing said substances. The invention also relates to several aspects of using said substances or pharmaceutical compositions to treat a disease.
Abstract translation: 本发明主要涉及分子结晶物质，优选结晶形式的达沙替尼盐，其包含式1化合物，优选式1化合物的阳离子和选自戊二酸，烟酸 和糖精，优选其阴离子。 本发明还涉及包含这种物质的药物组合物。 此外，本发明涉及制备所述物质的方法。 本发明还涉及使用所述物质或药物组合物治疗疾病的若干方面。
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2.发明申请公开(公告)号：US20140194453A1
公开(公告)日：2014-07-10
申请号：US14169844
申请日：2014-01-31
Applicant: BASF SE
Inventor： Andreas HAFNER , Fritz BLATTER , Martin SZELAGIEWICZ , Bernd SIEBENHAAR
IPC: A61K31/505 , A61K47/10
CPC classification number: A61K31/505 , A61K31/11 , A61K47/10 , C07D239/42
Abstract: A novel solid form of Rosuvastatin comprises as the active ingredient a salt of bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid] and vanillin or vanillin derivatives. The crystal comprising the two components, and minor amounts of water, shows improved properties such as crystallization behavior stability and decreased hydroscopic behavior.
Abstract translation: 新型固体形式的罗苏伐他汀作为活性成分包含双[（E）-7- [4-（4-氟苯基）-6-异丙基-2- [甲基（甲基磺酰基） - 氨基]嘧啶-5-基 ] - （3R，5S）-3,5-二羟基庚-6-烯酸]和香草醛或香草醛衍生物。 包含两种组分的晶体和少量的水显示出改进的性能，例如结晶行为稳定性和降低的吸水行为。
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公开(公告)号：US20180230140A1
公开(公告)日：2018-08-16
申请号：US15320608
申请日：2015-06-24
Applicant: BASF SE
Inventor： Martin VIERTELHAUS , Tiziana CHIODO , Beate SALVADOR , Marcus VOSSEN , Andreas HAFNER , Tobias HINTERMANN , Martin SZELAGIEWICZ , Fritz BLATTER
IPC: C07D417/14 , C07C39/06 , C07C47/58 , A61P35/02
CPC classification number: C07D417/14 , A61P35/02 , C07B2200/13 , C07C39/06 , C07C47/58 , C07D417/12
Abstract: The present invention primarily relates to multicomponent crystals comprising a compound of formula 1 and a second compound selected from the group consisting of menthol and vanillin. The invention is further related to pharmaceutical compositions comprising such multicomponent crystals. Furthermore, the invention relates to processes for preparing said multicomponent crystals. The invention also relates to several aspects of using said multicomponent crystals or pharmaceutical compositions to treat a disease.
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公开(公告)号：US20170363789A1
公开(公告)日：2017-12-21
申请号：US15539362
申请日：2015-12-18
Applicant: BASF SE
Inventor： Martin STALDER , Benjamin GALLINET , Fabian LUETOLF , Guilaume BASSET , Rolando FERRINI , Patrice BUJARD , Adrian VON MUEHLENEN , Andreas HAFNER
CPC classification number: G02B5/282 , C23C14/0629 , C23C14/20 , C23C14/5873 , E06B9/24 , E06B2009/2417 , G02B1/118 , G02B5/281 , H01L31/02168 , Y02E10/52
Abstract: A translucent or transparent film or sheet device shows angular-independent IR reflectance, which comprises a substrate (1) covered with a layer of a dielectric high refractive index material (4) containing a thin metallic layer (3) embedded in said material, and a further layer (5) of translucent or transparent material covering said layer (4) of dielectric high refractive index material, characterized in that the embedded metal layer (3) is periodically interrupted with a periodicity of 50 to 800 nm such that metal covers at least 70% of the substrate area. The device may advantageously be integrated into a window, a glass facade element or especially onto a photovoltaic (PV) device, where it reduces the fraction of IR radiation passing into the building, or reduces heat take-up and thus lowers the operating temperature and improves the efficiency of the PV cell.
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Patent Agency Ranking
公开(公告)号：US20210333448A1
公开(公告)日：2021-10-28
申请号：US17371510
申请日：2021-07-09
Applicant: BASF SE
Inventor： Andreas HAFNER , Adrian Von Muehlenen , Olivier Enger , Benjamin Gallinet , Rolando Ferrini , Nenad Marjanovic , Martin Stalder , Fabian Luetolf , Guillaume Basset
Abstract: A translucent construction element comprising a layer of translucent substrate, which contains a surface structured with nanoplanes of inclined angle relative to the substrate plane, and coated with an interrupted metallic layer covering at least a part of said nanoplanes, is characterized by a high density of interruptions in the metallic layer of low thickness; the periodicity of interruptions in the metallic layer generally is from the range 50 to 1000 nm and the thickness of the metallic layer typically is from the range 1 to 50 nm. The construction element may be integrated, for example, into windows, plastic films or sheets or glazings, especially for the purpose of light management.
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公开(公告)号：US20170216266A1
公开(公告)日：2017-08-03
申请号：US15501908
申请日：2015-08-03
Applicant: BASF SE
Inventor： MARTIN VIERTELHAUS , Tiziana CHIODO , Beate SALVADOR , Marcus VOSSEN , Andreas HAFNER , Tobias HINTERMANN , Walter WEISHAAR , Rolf HELLMANN
IPC: A61K31/4402 , C07D213/40
CPC classification number: A61K31/4402 , C07D213/40
Abstract: The present invention primarily relates to multi-component crystals comprising a compound of formula 1 and a second compound selected from the group consisting of co-crystal formers and solvents. The invention is further related to pharmaceutical compositions comprising such multi-component crystals. Furthermore, the invention relates to processes for preparing said multi-component crystals. The invention also relates to several aspects of using said multi-component crystals or pharmaceutical compositions to treat a disease.
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公开(公告)号：US20160303143A1
公开(公告)日：2016-10-20
申请号：US15103146
申请日：2014-12-09
Applicant: BASF SE
Inventor： Tiziana CHIODO , Beate SALVADOR , Marcus VOSSEN , Andreas HAFNER , Tobias HINTERMANN , Martin SZELAGIEWICZ , Fritz BLATTER , Martin VIERTELHAUS , Walter WEISHAAR
CPC classification number: A61K31/58 , A61K9/14 , C07B2200/13 , C07J43/003
Abstract: Combinations of (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate (Abiraterone acetate) with acidic substances such as citric acid, ascorbic acid, methyl-4-hydroxy benzoate, saccharin, vanillic acid, adipic acid, maleic acid, malic acid, tartaric acidare useful as pharmaceutical preparations and show improved properties such as aqueous solubility and dissolution kinetics, especially in the form of cocrystals or their combination with a suitable acid.
Abstract translation: （3β）-17-（吡啶-3-基）雄甾-5,16-二烯-3-基乙酸酯（醋酸阿比酮酮）与酸性物质如柠檬酸，抗坏血酸，甲基-4-羟基苯甲酸酯，糖精 ，香草酸，己二酸，马来酸，苹果酸，酒石酸可用作药物制剂，并显示出改善的性质，例如水溶性和溶解动力学，特别是以共晶体形式或与合适的酸的组合。
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公开(公告)号：US20160170102A1
公开(公告)日：2016-06-16
申请号：US14905400
申请日：2014-07-08
Applicant: BASF SE
Inventor： Andreas HAFNER , Adrian VON MUEHLENEN , Olivier ENGER , Benjamin GALLINET , Rolando FERRINI , Nenad MARJANOVIC , Martin STALDER , Fabian LUETOLF , Guillaume BASSET
Abstract: A translucent construction element comprising a layer of translucent substrate, which contains a surface structured with nanoplanes of inclined angle relative to the substrate plane, and coated with an interrupted metallic layer covering at least a part of said nanoplanes, is characterized by a high density of interruptions in the metallic layer of low thickness; the periodicity of interruptions in the metallic layer generally is from the range 50 to 1000 nm and the thickness of the metallic layer typically is from the range 1 to 50 nm. The construction element may be integrated, for example, into windows, plastic films or sheets or glazings, especially for the purpose of light management.
Abstract translation: 一种半透明结构元件，其包括透明基底层，该层包含由相对于基底平面倾斜的纳米平面构成的表面，并涂覆有覆盖所述纳米平面的至少一部分的中断金属层，其特征在于高密度 在低厚度的金属层中断; 金属层中断的周期通常为50〜1000nm，金属层的厚度通常为1〜50nm。 结构元件可以例如整合到窗户，塑料薄膜或薄板或玻璃窗中，特别是用于光管理的目的。
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公开(公告)号：US20160168142A1
公开(公告)日：2016-06-16
申请号：US14906974
申请日：2014-07-22
Applicant: BASF SE
Inventor： Andreas HAFNER , Fritz BLATTER , Martin SZELAGIEWICZ , Bernd SIEBENHAAR , Tiziana CHIODO , Tobias HINTERMANN , Beate SALVADOR , Marcus VOSSER
IPC: C07D417/12 , C07C55/12 , C07D213/80 , C07D275/06
CPC classification number: C07D417/12 , C07C55/12 , C07D213/80 , C07D275/06
Abstract: The present invention primarily relates to salts of Dasatinib, wherein the salts are in amorphous form. The salts described herein preferably comprise a cation of a compound of formula 1 and an anion of a second compound selected from the group consisting of glutaric acid, nicotinic acid and saccharin. The invention is further related to pharmaceutical compositions comprising such a salt. Furthermore, the invention relates to processes for preparing said salts. The invention also relates to several aspects of using said salt or pharmaceutical composition to treat a disease.
Abstract translation: 本发明主要涉及达沙替尼的盐，其中盐是无定形的。 本文所述的盐优选包含式1的化合物的阳离子和选自戊二酸，烟酸和糖精的第二化合物的阴离子。 本发明还涉及包含这种盐的药物组合物。 此外，本发明涉及制备所述盐的方法。 本发明还涉及使用所述盐或药物组合物治疗疾病的若干方面。
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