公开(公告)号：US20220356152A1

公开(公告)日：2022-11-10

申请号：US17636932

申请日：2020-08-20

Applicant: BASF SE

Inventor： Stefan BLEI ,  Jessica Nadine HAMANN ,  Lukas Karl METZGER ,  Christian SCHUETZ ,  Jun GAO ,  Frauke THRUN ,  Andreas MELZER ,  Michael Klemens MUELLER

IPC: C07C315/06

Abstract: The invention relates to a process for purifying crude 4,4′-dichlorodiphenyl sulfone comprising: (a) dissolving the crude 4,4′-dichlorodiphenyl sulfone which may contain water in an organic solvent in which 4,4′-dichlorodiphenyl sulfone has a solubility of 0.5 to 20% at 20° C. and optionally adding water to obtain a solution which comprises 4,4′-dichlorodiphenyl sulfone, the organic solvent and 1 to 30 wt % water based on the amount of 4,4′-dichlorodiphenyl sulfone and water; (b) cooling the solution to a temperature below the saturation point of 4,4′-dichlorodiphenyl sulfone to obtain a suspension comprising crystallized 4,4′-dichlorodiphenyl sulfone; (c) carrying out a solid-liquid separation to obtain residual moisture containing 4,4′-dichlorodiphenyl sulfone and a mother liquor; (d) washing the residual moisture containing 4,4′-dichlorodiphenyl sulfone with an organic solvent in which 4,4′-dichlorodiphenyl sulfone has a solubility of 0.5 to 20% at 20° C.; (e) optionally repeating steps (b) to (d); (f) drying the 4,4′-dichlorodiphenyl sulfone.

公开(公告)号：US20220340519A1

公开(公告)日：2022-10-27

申请号：US17635529

申请日：2020-08-20

Applicant: BASF SE

Inventor： Jessica Nadine HAMANN ,  Oliver BEY ,  Petra DECKERT ,  Andreas MELZER ,  Christian SCHUETZ ,  Stefan BLEI ,  Frauke THRUN

IPC: C07C315/06 ,  C08G75/23

Abstract: The invention relates to a process for purifying 4,4′-dichlorodiphenyl sulfone comprising: (a) providing a suspension comprising particulate 4,4′-dichlorodiphenyl sulfone in carboxylic acid, (b) carrying out a solid-liquid separation of the suspension to obtain residual moisture containing 4,4′-dichlorodiphenyl sulfone and a carboxylic acid comprising filtrate, (c) washing the residual moisture containing 4,4′-dichlorodiphenyl sulfone with an aqueous base and then with water, (d) mixing the aqueous base after being used for washing with a strong acid, or mixing the aqueous base after being used for washing, the carboxylic acid comprising filtrate and a strong acid, (e) carrying out a phase separation in which an aqueous phase and an organic phase comprising the carboxylic acid are obtained.

公开(公告)号：US20240025841A1

公开(公告)日：2024-01-25

申请号：US18265993

申请日：2021-12-16

Applicant: BASF SE

Inventor： Helmut KRONEMAYER ,  Sebastian WLOCH ,  Andreas MELZER ,  Mathieu BLANCHOT ,  Karin SCHEIN-ALBRECHT ,  Dennis KAUFHOLD ,  Thomas EHLIS

IPC: C07C227/42 ,  C07C227/16 ,  A61K8/41

CPC classification number: C07C227/42 ,  C07C227/16 ,  A61K8/411 ,  C07B2200/13

Abstract: The presently claimed invention relates to a method for obtaining crystalline diethylamino hydroxybenzoyl hexyl benzoate. Further, the presently claimed invention relates to crystalline diethylamino hydroxybenzoyl hexyl benzoate obtained by the method and to a cosmetic composition comprising crystalline diethylamino hydroxybenzoyl hexyl benzoate. The crystalline diethylamino hydroxybenzoyl hexyl benzoate obtained by the method of the presently claimed invention has a phthalic acid dihexyl ester (PSDHE) content in the range of 1 to 250 ppm.

公开(公告)号：US20220388949A1

公开(公告)日：2022-12-08

申请号：US17775966

申请日：2020-11-13

Applicant: BASF SE

Inventor： Stefan BLEI ,  Friedemann GAITZSCH ,  Christian SCHUETZ ,  Indre THIEL ,  Petra DECKERT ,  Jun GAO ,  Jessica Nadine HAMANN ,  Andreas MELZER

IPC: C07C315/06

Abstract: The invention relates to a process for working up water containing 4,4′-dichlorodiphenyl sulfoxide and/or 4,4′-dichlorodiphenyl sulfone as impurities, comprising: (a) mixing the water containing 4,4′-dichlorodiphenyl sulfoxide and/or 4,4′-dichlorodiphenyl sulfone as impurities with an organic solvent in which 4,4′-dichlorodiphenyl sulfoxide and/or 4,4′-dichlorodiphenyl sulfone have a solubility of at least 0.5 wt % based on the amount of 4,4′-dichlorodiphenyl sulfoxide and/or 4, 4′-dichlorodiphenyl sulfone and organic solvent at 20° C., which forms a two-phase system with water and which can be stripped from water with a stripping gas and subsequently separating the obtained mixture into an aqueous phase and an organic phase, and (b) stripping the organic solvent from the aqueous phase with a stripping gas.

公开(公告)号：US20220135523A1

公开(公告)日：2022-05-05

申请号：US17429200

申请日：2020-02-06

Applicant: BASF SE

Inventor： Indre THIEL ,  Christian SCHUETZ ,  Andreas MELZER ,  Stefan BLEI

IPC: C07C315/06

Abstract: The invention relates to a process for purifying 4,4′-dichlorodiphenyl sulfoxide comprising: (a) providing a suspension comprising particulate 4,4′-dichlorodiphenyl sulfoxide in monochlorobenzene, (b) solid-liquid separation of the suspension to obtain residual moisture containing 4,4′-dichlorodiphenyl sulfoxide, (c) washing residual moisture containing 4,4′-dichlorodiphenyl sulfoxide with monochlorobenzene, (d) optionally repeating steps (a) to (c).