公开(公告)号：US11299522B2

公开(公告)日：2022-04-12

申请号：US15779595

申请日：2016-12-02

Applicant: BASF SE

Inventor： Stefan Haefner ,  Andreas Thywissen ,  Holger Hartmann ,  Nico Boehmer

IPC: C12P21/00 ,  C12N9/14 ,  C12N1/15 ,  C07K14/37 ,  C12N9/16 ,  C12N9/24 ,  C12N15/80

Abstract: The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.

公开(公告)号：US10597429B2

公开(公告)日：2020-03-24

申请号：US15779646

申请日：2016-12-02

Applicant: BASF SE

Inventor： Stefan Haefner ,  Andreas Thywissen ,  Holger Hartmann ,  Nico Boehmer

IPC: C12P21/00 ,  C12P21/02 ,  C12Q1/34 ,  C12N1/14 ,  C12N15/01 ,  C12N15/80 ,  C12P19/14 ,  C07K14/37 ,  C12N9/42

Abstract: The present invention relates to a method of producing a recombinant polypeptide in a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 1 (CLR1) and to express the recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR1 and to the use of this filamentous fungus in the production of a recombinant polypeptide.

公开(公告)号：US20200308235A1

公开(公告)日：2020-10-01

申请号：US15779595

申请日：2016-12-02

Applicant: BASF SE

Inventor： Stefan Haefner ,  Andreas Thywissen ,  Holger Hartmann ,  Nico Boehmer

IPC: C07K14/37 ,  C12N9/16 ,  C12N9/24 ,  C12N15/80

Abstract: The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.

公开(公告)号：US20180354999A1

公开(公告)日：2018-12-13

申请号：US15779646

申请日：2016-12-02

Applicant: BASF SE

Inventor： Stefan Haefner ,  Andreas Thywissen ,  Holger Hartmann ,  Nico Boehmer

IPC: C07K14/37 ,  C12Q1/34

CPC classification number: C07K14/37 ,  C12N1/14 ,  C12N9/2437 ,  C12N15/01 ,  C12N15/80 ,  C12P19/14 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/34

Abstract: The present invention relates to a method of producing a recombinant polypeptide in a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 1 (CLR1) and to express the recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR1 and to the use of this filamentous fungus in the production of a recombinant polypeptide.