Abstract:
PHENYL-IMIDAZOLYLALKANYL DERIVATIVES ARE ANTIMYCOTIC AGENTS. THEY ARE PREPARED BY A NUMBER OF PROCESSES INCLUDING ACYLATION OR SULFONYLATION OF A PHENYL-IMIDAZOLYLALKANOL, TREATMENT OF A PHENYL-ALKANYL-CARBINOL WITH A DIIMIDAZOLLYL SULFONE, OXIDATION OF A PHENYL-IMIDAZOLYLALKYLMERCAPTAN OR REDUCTION OF A PHENYL-IMIDAZOLYLALKYLANOTE OR ALKANONITRILE. A TYPICAL EMBODIMENT IS 1-(1,1-DIPHENYL-2-ACETOXYETHYL) IMIDAZOLE.
Abstract:
Combating fungi with imidazole derivatives of the formula
IN WHICH R1 and R3 each independently is an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl or aralkyl radical, and R2 is hydrogen or one of the radicals recited for R1, X is oxygen or sulfur, and Y is a keto group or a functional derivative of a keto group, AND THEIR SALTS.
Abstract:
Antimicrobial aminoalkyl phenyl-azolylalkanoates and N(aminoalkyl)phenyl-azolylalkanamides and salts thereof are prepared by treatment of the corresponding phenyl-halo-alkanoate or alkanamide with an azolyl compound or saalt thereof, treatment of the corresponding phenyl-hydroxyalkanoate or phenylhydroxyalkanamide with an azole compound under dehydration conditions or with a thionyl-bis-azole, or transesterification or amidation of a (lower)alkyl phenyl-azolylalkanoate. A typical embodiment is diphenyl-imidazolyl-acetic acid 1-dimethylamino-2propyl ester.
Abstract:
Compositions containing and methods of using 1-ethylimidazoles of the formula
in which R1 and R3 each individually is hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, optionally substituted aryl or optionally substituted aralkyl, R2 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, optionally substituted aryl or optionally substituted aralkyl, Y is oxygen or sulfur, and X is a keto group or a functional derivative of a keto group, AS SUCH OR IN THE FORM OF SALTS, FOR COMBATING FUNGI.
Abstract:
3-(HYDROGEN-, (UNSUBSTITUTED AND HALO, AMINO, ALKYLAMINO, NITRO, ALKYL, ALKOXY, ALKYLMERCAPTO, ARYLOXY AND/OR HALOARYLMERCAPTO, SUBSTITUTED) ALIPHATIC-, CYCLOALIPHATIC-, ARALIPHATIC-, ARYL-, OR N-heterocyclic- or O-alkanoyl-, -substituted oxy, mercapto or amino)- 4-(amino; mono and di (unsubstituted and cyano, hydroxy and/or halo, -substituted) alkyl- and/or alkanoyl-, -amino; N(unsubstituted and cycloalkyl, aryl, haloaryl, alkaryl, alkoxy aryl, nitroaryl, halo-nitro-aryl, aryl-alkenyl, heterocyclic and/or nitro- heterocyclic- -substituted) alkylidene-amino or cycloalkylidene- amino; or N-heterocyclic)-6-((unsubstituted and halo, nitro, carbo lower alkoxy, alkyl, alkoxy, aryloxy, alkylmercapto, arylmercapto and/or aralkylmercapto, -substituted) aliphatic, cycloaliphatic, araliphatic, aryl, heterocyclic or heterocyclic- alkyl)-1,2,4-triazine-5-ones, which possess herbicidal properties, and which may be produced by conventional methods; herbicidal compositions containing such compounds; and methods of using such compounds as herbicides.
Abstract:
Phenyl-imidazolylalkanyl derivatives are antimycotic agents. They are prepared by a number of processes including acylation or sulfonylation of a phenyl-imidazolylalkanol, treatment of a phenyl-alkanyl-carbinol with a diimidazolyl sulfone, oxidation of a phenyl-imidazolylalkylmercaptan or reduction of a phenylimidazolylalkanoate or alkanonitrile. A typical embodiment is 1(1,1-diphenyl-2-acetoxyethyl)imidazole.
Abstract:
Antimycotic compositions are produced which comprise an antimycotically effective amount of a 1,2,4-triazole of the formula:
OR A PHARMACEUTICALLY ACCEPTABLE NON-TOXIC SALT THEREOF WHEREIN X 1 is hydrogen or alkyl; X2 is hydrogen or alkyl; R1 is alkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl; R2 is hydrogen, alkyl or unsubstituted or substituted aryl; R3 is alkyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl; and Y is a keto group or a functional derivative of a keto group, in combination with a pharmaceutically acceptable non-toxic, inert diluent or carrier.
Abstract:
HYDRAZONE DERIVATIVES OF BENZOYL CYANIDES, I.E. (OPTIONALLY CHLORO AND ALKYL SUBSITUTED-BNENZOYL CYANIDE-(N1 ALKYL-N2-(ALKYL AND ALKENYL)-AMIDINO)-HYDRAZONES AND (OPTIONALLY CHLORO AND ALKYL SUBSTITUTED)-BENZOYL CYANIDE1-(2,3-DIALKYL- AND -1-(2-ALKENYL-3-ALKYL ISOTHIOUREIDO)IMINES, WHICH POSSES HERBICIDAL PROPERTIES, AND WHICH MAY BE PRODUCED BY CONVENTIONAL METHODS.
Abstract:
in which X1 represents hydrogen or an alkyl radical, X2 represents hydrogen or an alkyl radical, R1 represents an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl or optionally substituted aryl or aralkyl radical, R2 represents hydrogen or an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl or optionally substituted aryl or aralkyl radical, R3 represents hydrogen or an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl or optionally substituted aryl or aralkyl radical, and Y represents a keto group or a functional keto derivative, WHICH POSSESS FUNGICIDAL PROPERTIES. 1-SUBSTITUTED-1,2,4-TRIAZOLES OF THE FORMULA
Abstract:
Imidazole derivatives of alkyl, cycloalkyl or aryl ketones are antimycotic agents. The compounds, of which 1-imidazolyl-1-(4''chlorophenoxy)-3,3-dimethylbutan-2-one is a typical embodiment, can be obtained from the corresponding hydroxy or halo ketone through treatment with imidazole.