公开(公告)号：US20220098160A1

公开(公告)日：2022-03-31

申请号：US17052078

申请日：2019-02-28

Applicant: BIOCAD

Inventor： Aleksei Leonidovich MINDICH ,  Svetlana Leonidovna GORBUNOVA ,  Aleksandra Vladimirovna POPKOVA ,  Artsiom Evgenievich SHEKHAUTSOU ,  Andrei Ivanovich ALAFINOV ,  Mariia Andreevna KASATKINA ,  Natalia Vladimirovna KOZHEMYAKINA ,  Anna Sergeevna KUSHAKOVA ,  Elena Aleksandrovna MAKSIMENKO ,  Leonid Evgen`evich MIKHAYLOV ,  Mariia Sergeevna MISHINA ,  Anna Jur'evna CHESTNOVA ,  Dmitry Valentinovich MOROZOV

IPC: C07D239/80 ,  A61P35/00 ,  C07D239/95 ,  C07D237/28 ,  C07D215/48 ,  C07D471/04

Abstract: The present invention relates to novel compounds of formula (1), which have the properties of a CDK8/19 inhibitor, and to a pharmaceutical composition containing said compounds, and to the use of said compounds and composition as pharmaceutical preparations for treating diseases or disorders.

公开(公告)号：US20210246138A1

公开(公告)日：2021-08-12

申请号：US17264670

申请日：2019-07-31

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Aleksei Leonidovich MINDICH ,  Anna Jur'evna CHESTNOVA ,  Mariia Andreevna KASATKINA ,  Andrei Ivanovich ALAFINOV ,  Aleksei Sergeevich GAVRILOV ,  Anton Aleksandrovich EVDOKIMOV ,  Liliana Vyacheslavovna LENSHMIDT ,  Elena Aleksandrovna MAKSIMENKO ,  Mariia Sergeevna MISHINA ,  Sergei Aleksandrovich SILONOV ,  Evgenii Jur'evich SMIRNOV ,  Pavel Andreevich IAKOVLEV ,  Dmitry Valentinovich MOROZOV

IPC: C07D471/04 ,  A61P35/00

Abstract: The present invention relates to novel compounds of formula I: which have the properties of CDK8/19 inhibitors, to a pharmaceutical composition comprising said compounds, and to use thereof as a medicine for treating diseases and disorders.