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公开(公告)号：US20230321220A1
公开(公告)日：2023-10-12
申请号：US18043354
申请日：2021-08-27
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Alexander Vladimirovich PROKOFYEV , Pavel Mikhailovich GERSHOVICH , Anna Nikolaevna STRELKOVA , Natalia Aleksandrovna SPIRINA , Diana Aleksandrovna KONDINSKAIA , Pavel Andreevich IAKOVLEV , Dmitry Valentinovich MOROZOV
IPC: A61K39/215 , C12N15/86 , C07K14/005 , C07K14/61 , A61P31/12
CPC classification number: A61K39/215 , C12N15/86 , C07K14/005 , C07K14/61 , A61P31/12 , C12N2770/20022 , C12N2770/20034 , C12N2770/20071 , C12N2750/14143 , A61K2039/5256
Abstract: The present application relates to the fields of biotechnology, immunology, virology, genetics, and molecular biology. More specifically, the present invention relates to an isolated recombinant receptor-binding domain of the S glycoprotein (RBD-S) of SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus 2), to a nucleic acid that encodes RBD-S of SARS-CoV-2, to an expression cassette and a vector based thereon, as well as to a recombinant AAV5 (adeno-associated vims serotype 5)-based virus for the induction of specific immunity to SARS-CoV-2 and/or prevention of the SARS-CoV-2-related coronavirus infection, to an AAV5-based vaccine for the induction of specific immunity to SARS-CoV-2 and/or prevention of the SARS-CoV-2-related coronavirus infection, and to their use for the induction of specific immunity to SARS-CoV-2 and/or prevention of the SARS-CoV-2-related coronavirus infection.
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公开(公告)号：US20220112286A1
公开(公告)日：2022-04-14
申请号：US17417686
申请日：2020-02-20
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Olga Vladimirovna BRITANOVA , Dmitry Borisovich STAROVEROV , Anna Valentinovna EVSTRATEVA , Alexey Konstantinovich MISORIN , Timofey Aleksandrovich NEMANKIN , Mariia Aleksandrovna SHCHEMELEVA , Anna Konstantinovna VLADIMIROVA , Arina Vitalevna ANIKINA , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV , Pavel Andreevich IAKOVLEV , Sergey Anatolievich LUKYANOV
IPC: C07K16/28
Abstract: The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.
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公开(公告)号：US20250127923A1
公开(公告)日：2025-04-24
申请号：US18684921
申请日：2022-08-21
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Anna Nikolaevna STRELKOVA , Sergei Aleksandrovich LEGOTSKII , Tatiana Evgenievna SHUGAEVA , Pavel Mikhailovich GERSHOVICH , Alexander Vladimirovich PROKOFYEV , Mariya Pavlovna PEREPELKINA , Pavel Andreevich IAKOVLEV , Dmitry Valentinovich MOROZOV
IPC: A61K48/00 , C07K14/005 , C12N15/86
Abstract: The present application relates to the fields of gene therapy and molecular biology. More specifically, the present invention relates to an isolated modified capsid protein VP1 from adeno-associated virus serotype 5 (AAV5), comprising one or more amino acid substitutions compared to the wild-type AAV5 capsid protein VP1, which substitutions increase the efficiency of transduction, increase the efficiency of packaging of AAV viral genomes with rAAV5-based products, and also increase the efficiency of production (assembly) of a vector based on recombinant adeno-associated virus serotype 5 (rAAV5), to a capsid and a vector based on the above VP1, as well as to uses thereof.
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公开(公告)号：US20240350663A1
公开(公告)日：2024-10-24
申请号：US18684886
申请日：2022-08-21
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Anna Nikolaevna STRELKOVA , Tatiana Evgenievna SHUGAEVA , Pavel Mikhailovich GERSHOVICH , Pavel Andreevich IAKOVLEV , Dmitry Valentinovich MOROZOV
IPC: A61K48/00 , C07K14/005 , C12N15/86
CPC classification number: A61K48/0041 , C07K14/005 , C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151
Abstract: The present application relates to the fields of gene therapy and molecular biology. More specifically, the present invention relates to an isolated modified capsid protein VP1 from adeno-associated virus serotype 9 (AAV9) comprising one or more amino acid substitutions compared to the wild-type AAV9 capsid protein VP1, which substitutions increase the efficiency of production (assembly) of the vector based on recombinant adeno-associated virus serotype 9 (rAAV9), to a capsid and a vector based on the above VP1, as well as to uses thereof.
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公开(公告)号：US20240034764A1
公开(公告)日：2024-02-01
申请号：US18266001
申请日：2021-12-10
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Aleksey Vladimirovich KONONOV , Iuliia Viktorovna EVDOKIMOVSKAIA , Iana Andreevna SMIRNOVA , Stanislav Rudolfovich EVDOKIMOV , Elena Sergeevna KOLOSOVA , Sergei Andreevich AGEEV , Vladimir Sergeevich TSYMPILOV , Valery Vladimirovich SOLOVYEV , Pavel Andreevich IAKOVLEV , Dmitry Valentinovich MOROZOV
CPC classification number: C07K14/5428 , C12N15/63 , A61P35/00 , C07K16/2818 , C07K2319/30
Abstract: The present invention relates to the field of biotechnology and medicine, in particular to an immunocytokine for activating the human IL-10Rα receptor. The invention further relates to nucleic acids encoding said immunocytokine, expression vectors, host cells and methods for producing same, methods for producing the immunocytokine, pharmaceutical compositions comprising the above immunocytokine, pharmaceutical compositions comprising the above immunocytokine and other therapeutically active compounds, methods for treating an oncological disease and the uses of the immunocytokine or pharmaceutical compositions thereof for treating an oncological disease.
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Patent Agency Ranking
公开(公告)号：US20200291121A1
公开(公告)日：2020-09-17
申请号：US16753488
申请日：2018-10-02
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Ekaterina Vladimirovna SOFRONOVA , Aleksei Konstantinovich MISORIN , Aleksandr Nikolaevich DORONIN , Timofey Aleksandrovich NEMANKIN , Aleksandra Aleksandrovna SOZONOVA , Galina Stepanovna ZHIRIVSKAIA , Sergey Aleksandrovich LEGOTSKY , Anna Konstantinovna VLADIMIROVA , Alina Valerevna BELIASNIKOVA , Mariia Aleksandrovna SHCHEMELEVA , Pavel Andreevich IAKOVLEV , Valery Vladimirovich SOLOVYEV , Elena Andreevna KRENDELEVA , Natalia Evgenevna PESTOVA , Dmitry Valentinovich MOROZOV
Abstract: The present invention relates to biotechnology and provides antibodies that specifically bind to IL-5Rα. The invention also relates to DNA encoding said antibodies, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibodies.
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7.发明申请公开(公告)号：US20190194313A1
公开(公告)日：2019-06-27
申请号：US16325528
申请日：2017-08-03
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Stanislav Rudolfovich EVDOKIMOV , Andrei Borisovich ULITIN , Valery Vladimirovich SOLOVYEV , Aleksei Aleksandrovich ALEKSANDROV , Yulia Sergeevna CHERNYKH , Timofey Aleksandrovich NEMANKIN , Anna Konstantinovna VLADIMIROVA , Oleg Igorevich SMOTROV , Tatiana Veniaminovna CHERNOVSKAYA , Aleksandr Aleksandrovich MOSHCHENKO , Viktoriia Evgenevna NALOBINA , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV
CPC classification number: C07K16/248 , A61K9/0073 , A61K9/19 , A61K39/395 , A61P37/00 , A61P37/06 , A61P37/08 , C07K16/065 , C07K16/18 , C07K16/24 , C12N15/00 , C12N15/63
Abstract: The invention relates to medicine. The problem addressed by the present invention consists in creating alternative antibodies or fragments thereof which are capable of specifically binding to a human receptor of interleukin-6 and which would be useful as drugs for treating or diagnosing diseases, or for relieving symptoms, mediated by interleukin-6.
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公开(公告)号：US20220064612A1
公开(公告)日：2022-03-03
申请号：US17276016
申请日：2019-09-13
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Dmitriy Aleksandrovich MADERA , Aleksandr Vladimirovich KARABELSKII , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV , Konstantin Viktorovich SEVERINOV , Sergey Anatolevich SHMAKOV , Dmitrii Aleksandrovich SUTORMIN , Georgii Evgenevich POBEGALOV , Aleksandra Andreevna VASILEVA , Polina Anatolevna SELKOVA , Anatolii Nikolaevich ARSENIEV , Tatyana Igorevna ZYUBKO , Iana Vitalevna FEDOROVA
Abstract: The present invention relates to the field of biotechnology, molecular biology and medicine, in particular to nuclease enzyme and use thereof. More specifically, the present invention relates to PaCas9 nuclease enzyme. The invention also relates to a nucleic acid encoding said nuclease, a genetic construct, an expression vector, a delivery vector, which comprise said nucleic acid, a liposome comprising said nuclease or nucleic acid encoding said nuclease, a method for producing a nuclease, methods for delivery, and a host cell comprising a nucleic acid encoding said nuclease.
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公开(公告)号：US20220056133A1
公开(公告)日：2022-02-24
申请号：US17417570
申请日：2019-12-24
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Olga Vladimirovna BRITANOVA , Dmitry Borisovich STAROVEROV , Anna Valentinovna EVSTRATEVA , Alexey Konstantinovich MISORIN , Timofey Aleksandrovich NEMANKIN , Mariia Aleksandrovna SHCHEMELEVA , Anna Konstantinovna VLADIMIROVA , Arina Vitalevna ANIKINA , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV , Pavel Andreevich IAKOVLEV , Sergey Anatolievich LUKYANOV
IPC: C07K16/28 , A61K45/06 , A61K39/395
Abstract: The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.
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公开(公告)号：US20210246138A1
公开(公告)日：2021-08-12
申请号：US17264670
申请日：2019-07-31
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Aleksei Leonidovich MINDICH , Anna Jur'evna CHESTNOVA , Mariia Andreevna KASATKINA , Andrei Ivanovich ALAFINOV , Aleksei Sergeevich GAVRILOV , Anton Aleksandrovich EVDOKIMOV , Liliana Vyacheslavovna LENSHMIDT , Elena Aleksandrovna MAKSIMENKO , Mariia Sergeevna MISHINA , Sergei Aleksandrovich SILONOV , Evgenii Jur'evich SMIRNOV , Pavel Andreevich IAKOVLEV , Dmitry Valentinovich MOROZOV
IPC: C07D471/04 , A61P35/00
Abstract: The present invention relates to novel compounds of formula I: which have the properties of CDK8/19 inhibitors, to a pharmaceutical composition comprising said compounds, and to use thereof as a medicine for treating diseases and disorders.
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