公开(公告)号：US20200339544A1

公开(公告)日：2020-10-29

申请号：US16753847

申请日：2018-10-05

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Kirill Vadimovich ZAVIALOV ,  Svetlana Leonidovna GORBUNOVA ,  Artsiom Evgenievich SHEKHAUTSOU ,  Mariia Andreevna KASATKINA ,  Daria Dmitrievna BEKETOVA ,  Natalia Vladimirovna KOZHEMYAKINA ,  Kirill Igorevich KULISH ,  Elena Aleksandrovna MAKSIMENKO ,  Marina Viktorovna MELESHINA ,  Olga Anatolevna MELCHAEVA ,  Aleksei Leonidovich MINDICH ,  Dmitry Valentinovich MOROZOV ,  Aleksandra Vladimirovna POPKOVA ,  Ilia Alexeevich SMETANIN ,  Sergey Aleksandrovich SILONOV ,  Iaroslavna Alexandrovna SOLDATOVA ,  Georgii Viktorovich IAKOBSON

IPC: C07D403/06 ,  C07D239/42 ,  C07D213/74 ,  C07D413/10 ,  C07D401/06 ,  A61P35/00

Abstract: The present invention relates to novel compounds of formula I, or pharmaceutically acceptable salts, solvates or stereoisomers thereof, also to a pharmaceutical composition, a method for inhibiting biological activity of epidermal growth factor receptor (EGFR), a method for treating diseases or disorders mediated by the activation of EGFR and use of the present compounds or the present pharmaceutical composition for the treatment of a disease or disorder mediated by the activation of EGFR.

公开(公告)号：US20220098160A1

公开(公告)日：2022-03-31

申请号：US17052078

申请日：2019-02-28

Applicant: BIOCAD

Inventor： Aleksei Leonidovich MINDICH ,  Svetlana Leonidovna GORBUNOVA ,  Aleksandra Vladimirovna POPKOVA ,  Artsiom Evgenievich SHEKHAUTSOU ,  Andrei Ivanovich ALAFINOV ,  Mariia Andreevna KASATKINA ,  Natalia Vladimirovna KOZHEMYAKINA ,  Anna Sergeevna KUSHAKOVA ,  Elena Aleksandrovna MAKSIMENKO ,  Leonid Evgen`evich MIKHAYLOV ,  Mariia Sergeevna MISHINA ,  Anna Jur'evna CHESTNOVA ,  Dmitry Valentinovich MOROZOV

IPC: C07D239/80 ,  A61P35/00 ,  C07D239/95 ,  C07D237/28 ,  C07D215/48 ,  C07D471/04

Abstract: The present invention relates to novel compounds of formula (1), which have the properties of a CDK8/19 inhibitor, and to a pharmaceutical composition containing said compounds, and to the use of said compounds and composition as pharmaceutical preparations for treating diseases or disorders.