公开(公告)号：US11572356B2

公开(公告)日：2023-02-07

申请号：US17004411

申请日：2020-08-27

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Timothy Raymond Chan ,  Lihong Sun ,  Lei Zhang ,  Gnanasambandam Kumaravel ,  Joseph P. Lyssikatos ,  Kevin Koch ,  Hua Miao

IPC: C07D403/12 ,  C07D417/14 ,  C07D495/04 ,  C07D409/14 ,  C07D401/14 ,  C07D513/04 ,  C07D413/14 ,  A61K31/506 ,  C07D239/30 ,  C07F5/02 ,  C07D417/12 ,  C07D487/04

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

公开(公告)号：US10577374B2

公开(公告)日：2020-03-03

申请号：US15698171

申请日：2017-09-07

Applicant: Sunesis Pharmaceuticals, Inc. ,  Biogen MA Inc.

Inventor： Minna Bui ,  Patrick Conlon ,  Julio H. Cuervo ,  Daniel A. Erlanson ,  Junfa Fan ,  Bing Guan ,  Brian T. Hopkins ,  Tracy J. Jenkins ,  Gnanasambandam Kumaravel ,  Alexey A. Lugovskoy ,  Doug Marcotte ,  Noel Powell ,  Daniel Scott ,  Laura Silvian ,  Art Taveras ,  Deping Wang ,  Min Zhong

IPC: C07D277/82 ,  C07D487/14 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  A61K31/519

Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.

公开(公告)号：US20190382394A1

公开(公告)日：2019-12-19

申请号：US16410725

申请日：2019-05-13

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Jürgen Schulz ,  Marta Nevalainen ,  Michael Dechantsreiter

IPC: C07D413/14 ,  C07D405/14 ,  C07D403/14

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US20190218204A1

公开(公告)日：2019-07-18

申请号：US16108755

申请日：2018-08-22

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Timothy Raymond Chan ,  Lihong Sun ,  Lei Zhang ,  Gnanasambandam Kumaravel ,  Joseph P. Lyssikatos ,  Kevin Koch ,  Hua Miao

IPC: C07D403/12 ,  C07F5/02 ,  C07D239/30 ,  A61K31/506 ,  C07D487/04 ,  C07D513/04 ,  C07D401/14 ,  C07D417/14 ,  C07D417/12 ,  C07D409/14 ,  C07D413/14 ,  C07D495/04

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

公开(公告)号：US20180297992A1

公开(公告)日：2018-10-18

申请号：US15952505

申请日：2018-04-13

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Joseph P. Lyssikatos ,  Fengmei Zheng ,  Matthew Peterson ,  Daniel B. Patience

IPC: C07D417/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  A61P43/00

CPC classification number: C07D417/14 ,  A61K31/44 ,  A61K31/443 ,  A61K31/506 ,  A61P43/00 ,  C07B2200/13 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US10081619B2

公开(公告)日：2018-09-25

申请号：US15699857

申请日：2017-09-08

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Timothy Raymond Chan ,  Lihong Sun ,  Lei Zhang ,  Gnanasambandam Kumaravel ,  Joseph P. Lyssikatos ,  Kevin Koch ,  Hua Miao

IPC: C07D403/12 ,  C07D487/04 ,  C07D401/14 ,  C07D413/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D495/04 ,  C07D513/04

CPC classification number: C07D403/12 ,  A61K31/506 ,  C07D239/30 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  C07F5/027

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

公开(公告)号：US20180093973A1

公开(公告)日：2018-04-05

申请号：US15699857

申请日：2017-12-20

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Timothy Raymond Chan ,  Lihong Sun ,  Lei Zhang ,  Gnanasambandam Kumaravel ,  Joseph P. Lyssikatos ,  Kevin Koch ,  Hua Miao

IPC: C07D403/12 ,  C07D487/04 ,  C07D401/14 ,  C07D413/14 ,  C07D409/14 ,  C07D417/14 ,  C07D495/04 ,  C07D513/04 ,  C07D417/12

CPC classification number: C07D403/12 ,  A61K31/506 ,  C07D239/30 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  C07F5/027

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

公开(公告)号：US20170027956A1

公开(公告)日：2017-02-02

申请号：US15055910

申请日：2016-02-29

Applicant: Biogen MA Inc. ,  Sunesis Pharmaceuticals, Inc.

Inventor： Brian T. Hopkins ,  Daniel Scott ,  Patrick Conlon ,  Tracy J. Jenkins ,  Noel Powell ,  Bing Guan ,  Julio H. Cuervo ,  Deping Wang ,  Art Taveras

IPC: A61K31/553 ,  A61K31/4545 ,  A61K31/55 ,  A61K31/519 ,  A61K31/506 ,  A61K31/52 ,  A61K31/496 ,  A61K31/5377

CPC classification number: A61K31/553 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/55 ,  C07D401/12 ,  C07D403/04 ,  C07D413/12 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same.

Abstract translation: 本发明提供可用作Tec家族激酶抑制剂的化合物，其组合物及其使用方法。

公开(公告)号：US20240287076A1

公开(公告)日：2024-08-29

申请号：US18289438

申请日：2022-05-05

Applicant: BIOGEN MA INC. ,  C4 THERAPEUTICS, INC.

Inventor： Kevin M. Guckian ,  Eric Stefan ,  Corey Don Anderson ,  Jae Young Ahn ,  Morgan Welzel O'Shea ,  Jeremy L. Yap ,  Xinpeng Cheng ,  Brian T. Hopkins ,  Isaac Marx ,  Marta Nevalainen

IPC: C07D487/04 ,  A61K31/53

CPC classification number: C07D487/04 ,  A61K31/53

Abstract: This disclosure relates to compounds of Formula (A): BTK-L-DSM (A) or a pharmaceutically acceptable salt thereof, wherein DSM is a degradation signaling moiety that is covalently attached to the linker L, L is a linker that covalently attaches BTK to DSM, and BTK is a Btk binding moiety represented by Formula (I) or Formula (II) that is covalently attached to linker L: in which all of the variables are as defined in the application. Compounds or pharmaceutically acceptable salts thereof as described herein are capable of activating the selective ubiqitination of Btk proteins via the ubiquitin-proteasome pathways (UPP) and cause degradation of Btk proteins. The present disclosure also provides methods of treating disorders responsive to modulation of Btk activity and/or degradation of Btk with at least one compound described herein.

公开(公告)号：US20220411429A1

公开(公告)日：2022-12-29

申请号：US17773471

申请日：2020-10-29

Applicant: BIOGEN MA INC.

Inventor： Isaac Marx ,  Jürgen Schulz ,  Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Marta Nevalainen

IPC: C07D487/04 ,  C07D519/00

Abstract: Provided are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein ring A, R3, R4, R5, R6, A1, B1, B2, Q1 and Q2 are as defined herein; and methods for their use and production.