公开(公告)号：US20240287076A1

公开(公告)日：2024-08-29

申请号：US18289438

申请日：2022-05-05

申请人： BIOGEN MA INC. ,  C4 THERAPEUTICS, INC.

发明人： Kevin M. Guckian ,  Eric Stefan ,  Corey Don Anderson ,  Jae Young Ahn ,  Morgan Welzel O'Shea ,  Jeremy L. Yap ,  Xinpeng Cheng ,  Brian T. Hopkins ,  Isaac Marx ,  Marta Nevalainen

IPC分类号： C07D487/04 ,  A61K31/53

CPC分类号： C07D487/04 ,  A61K31/53

摘要： This disclosure relates to compounds of Formula (A): BTK-L-DSM (A) or a pharmaceutically acceptable salt thereof, wherein DSM is a degradation signaling moiety that is covalently attached to the linker L, L is a linker that covalently attaches BTK to DSM, and BTK is a Btk binding moiety represented by Formula (I) or Formula (II) that is covalently attached to linker L: in which all of the variables are as defined in the application. Compounds or pharmaceutically acceptable salts thereof as described herein are capable of activating the selective ubiqitination of Btk proteins via the ubiquitin-proteasome pathways (UPP) and cause degradation of Btk proteins. The present disclosure also provides methods of treating disorders responsive to modulation of Btk activity and/or degradation of Btk with at least one compound described herein.

公开(公告)号：US20190382394A1

公开(公告)日：2019-12-19

申请号：US16410725

申请日：2019-05-13

申请人： BIOGEN MA INC.

发明人： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Jürgen Schulz ,  Marta Nevalainen ,  Michael Dechantsreiter

IPC分类号： C07D413/14 ,  C07D405/14 ,  C07D403/14

摘要： Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US20180297992A1

公开(公告)日：2018-10-18

申请号：US15952505

申请日：2018-04-13

申请人： BIOGEN MA INC.

发明人： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Joseph P. Lyssikatos ,  Fengmei Zheng ,  Matthew Peterson ,  Daniel B. Patience

IPC分类号： C07D417/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  A61P43/00

CPC分类号： C07D417/14 ,  A61K31/44 ,  A61K31/443 ,  A61K31/506 ,  A61P43/00 ,  C07B2200/13 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

摘要： Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US11858926B2

公开(公告)日：2024-01-02

申请号：US17871157

申请日：2022-07-22

申请人： BIOGEN MA INC.

发明人： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Joseph P. Lyssikatos ,  Fengmei Zheng ,  Matthew Peterson ,  Daniel B. Patience

IPC分类号： C07D417/14 ,  C07D403/14 ,  C07D413/14 ,  C07D405/14 ,  C07D471/04 ,  A61P43/00 ,  A61P1/16

CPC分类号： C07D417/14 ,  A61P1/16 ,  A61P43/00 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07B2200/13

摘要： Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US10961237B2

公开(公告)日：2021-03-30

申请号：US16534540

申请日：2019-08-07

申请人： BIOGEN MA INC.

发明人： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Joseph P. Lyssikatos ,  Fengmei Zheng ,  Matthew Peterson ,  Daniel B. Patience

IPC分类号： C07D417/14 ,  C07D403/14 ,  C07D413/14 ,  C07D405/14 ,  C07D471/04 ,  A61P43/00 ,  A61P1/16

摘要： Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US10899753B2

公开(公告)日：2021-01-26

申请号：US16410725

申请日：2019-05-13

申请人： BIOGEN MA INC.

发明人： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Jürgen Schulz ,  Marta Nevalainen ,  Michael Dechantsreiter

IPC分类号： C07D413/14 ,  C07D403/14 ,  C07D405/14

摘要： Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US20240083900A1

公开(公告)日：2024-03-14

申请号：US18036853

申请日：2021-11-12

申请人： BIOGEN MA INC.

发明人： Brian T. Hopkins ,  Bin Ma ,  Isaac Marx ,  Jürgen Schulz ,  George Vandeveer ,  Robin Prince ,  Marta Nevalainen ,  TeYu Chen ,  Zain Yousaf ,  Martin Himmelbauer ,  Vatee Pattaropong ,  John Howard Jones ,  Edward Yin-Shiang Lin ,  Felix Gonzalez Lopez de Turiso ,  Thomas Purgett ,  Andrew George Capacci ,  Simone Sciabola

IPC分类号： C07D487/04 ,  C07D471/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D519/00

摘要： Provided are compounds of Formula (I′): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.

公开(公告)号：US20210340135A1

公开(公告)日：2021-11-04

申请号：US17183702

申请日：2021-02-24

申请人： BIOGEN MA INC.

发明人： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Joseph P. Lyssikatos ,  Fengmei Zheng ,  Matthew Peterson ,  Daniel B. Patience

IPC分类号： C07D417/14 ,  C07D403/14 ,  C07D413/14 ,  A61P43/00 ,  C07D405/14 ,  C07D471/04 ,  A61P1/16

摘要： Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US20180362522A1

公开(公告)日：2018-12-20

申请号：US16113455

申请日：2018-08-27

申请人： BIOGEN MA INC.

发明人： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Joseph P. Lyssikatos ,  Fengmei Zheng ,  Matthew Peterson ,  Daniel B. Patience

IPC分类号： C07D417/14 ,  A61P43/00 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

CPC分类号： C07D417/14 ,  A61K31/44 ,  A61K31/443 ,  A61K31/506 ,  A61P43/00 ,  C07B2200/13 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

摘要： Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US20220411429A1

公开(公告)日：2022-12-29

申请号：US17773471

申请日：2020-10-29

申请人： BIOGEN MA INC.

发明人： Isaac Marx ,  Jürgen Schulz ,  Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Marta Nevalainen

IPC分类号： C07D487/04 ,  C07D519/00

摘要： Provided are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein ring A, R3, R4, R5, R6, A1, B1, B2, Q1 and Q2 are as defined herein; and methods for their use and production.