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公开(公告)号：US10577374B2
公开(公告)日：2020-03-03
申请号：US15698171
申请日：2017-09-07
Applicant: Sunesis Pharmaceuticals, Inc. , Biogen MA Inc.
Inventor： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: C07D277/82 , C07D487/14 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04 , A61K31/519
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
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公开(公告)号：US20170027956A1
公开(公告)日：2017-02-02
申请号：US15055910
申请日：2016-02-29
Applicant: Biogen MA Inc. , Sunesis Pharmaceuticals, Inc.
Inventor： Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
IPC: A61K31/553 , A61K31/4545 , A61K31/55 , A61K31/519 , A61K31/506 , A61K31/52 , A61K31/496 , A61K31/5377
CPC classification number: A61K31/553 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/55 , C07D401/12 , C07D403/04 , C07D413/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D513/04 , C07D519/00
Abstract: The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供可用作Tec家族激酶抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US20170158687A1
公开(公告)日：2017-06-08
申请号：US15296601
申请日：2016-10-18
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: C07D451/02 , C07D401/06 , A61K45/06 , A61K31/4725 , C07D217/22 , A61K31/472
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
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公开(公告)号：US09567392B2
公开(公告)日：2017-02-14
申请号：US14386262
申请日：2013-03-15
Applicant: Biogen MA Inc.
Inventor： Kenneth Simon , Thomas Cameron , Deping Wang , Joseph Arndt , Mia Rushe , Justin Caravella , Eric Day
IPC: C07K16/08
CPC classification number: C07K16/084 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
Abstract: In one aspect, the disclosure provides neutralizing antibodies against JCV and methods for the treatment of PML. In some embodiments, aspects of the invention relate to an isolated JC-vims neutralizing monoclonal antibody against JCV capsid protein VPI (JCV-VP1). In some embodiments, the antibody suppresses infectivity of the JC-vims. In some embodiments, the antibody binds the sialic acid binding pocket of JCV-VP1.
Abstract translation: 一方面，本公开提供了针对JCV的中和抗体和用于治疗PML的方法。 在一些实施方案中，本发明的方面涉及针对JCV衣壳蛋白VPI（JCV-VP1）的分离的JC-vim中和单克隆抗体。 在一些实施方案中，抗体抑制JC-vims的感染性。 在一些实施方案中，抗体结合JCV-VP1的唾液酸结合口袋。
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公开(公告)号：US10017506B2
公开(公告)日：2018-07-10
申请号：US15296601
申请日：2016-10-18
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: A61K31/015 , A61K31/4375 , A61K31/44 , C07D451/02 , C07D217/22 , A61K31/472 , A61K45/06 , A61K31/4725 , C07D401/06
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
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Patent Agency Ranking
公开(公告)号：US09790229B2
公开(公告)日：2017-10-17
申请号：US15006061
申请日：2016-01-25
Applicant: Biogen MA Inc. , Sunesis Pharmaceuticals, Inc.
Inventor： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: C07D487/14 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04 , A61K31/519
CPC classification number: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
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公开(公告)号：US09555050B2
公开(公告)日：2017-01-31
申请号：US14417353
申请日：2013-07-26
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Zhaohui Shao , Lihong Sun , Arthur Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: C07D215/20 , A61K31/662 , A61K45/06 , C07D401/04 , C07D401/06 , C07C229/48 , C07D265/30 , C07D211/34 , C07D211/62 , C07D213/79 , C07D223/06 , C07C233/47 , C07D205/04 , C07D207/08 , C07D207/16 , C07C229/46 , C07F9/38 , A61K31/196 , A61K31/397 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/5375 , A61K31/55 , C07D213/80
CPC classification number: A61K31/662 , A61K31/196 , A61K31/397 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C229/46 , C07C229/48 , C07C233/47 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/26 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/34 , C07D211/62 , C07D213/79 , C07D213/80 , C07D215/20 , C07D223/06 , C07D265/30 , C07D401/04 , C07D401/06 , C07F9/38 , C07F9/3808
Abstract: Compounds of formula (I) can modulate the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物可调节自分泌素（ATX）的活性。
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公开(公告)号：US20160376281A1
公开(公告)日：2016-12-29
申请号：US15006061
申请日：2016-01-25
Applicant: Biogen MA Inc. , Sunesis Pharmaceuticals, Inc.
Inventor： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: C07D487/14 , C07D413/14 , C07D417/14 , C07D401/14 , C07D401/04 , C07D473/34
CPC classification number: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US09522889B2
公开(公告)日：2016-12-20
申请号：US14417300
申请日：2013-07-26
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: A61K31/015 , A61K31/44 , A61K31/4375 , C07D295/096 , C07D223/06 , A61K45/06 , C07D217/22 , C07D471/08 , C07D211/34 , C07D211/62 , C07C255/59 , C07C229/46 , C07C229/48 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/5375 , A61K31/55 , C07C217/22 , C07D209/52 , C07D221/22
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
Abstract translation: 公开了式（I）的双环芳基化合物，其可以调节自分泌素（ATX）酶的活性。 本发明还涉及作为ATX抑制剂的化合物，以及制备和使用这些化合物治疗由于损伤或疾病引起的脱髓鞘以及治疗增殖性疾病如癌症的方法。
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公开(公告)号：US20160039825A1
公开(公告)日：2016-02-11
申请号：US14772481
申请日：2014-03-14
Applicant: BIOGEN MA INC.
Inventor： Hairuo Peng , Zhili Xin , Lei Zhang , Lihong Sun , Gnanasambandam Kumaravel , Art Taveras , Deping Wang
IPC: C07D487/04 , C07D519/00
CPC classification number: A61K31/198 , A61K36/9068 , C07D487/04 , C07D519/00
Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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