公开(公告)号：US20220118093A1

公开(公告)日：2022-04-21

申请号：US17297193

申请日：2019-11-18

申请人： BIONEER CORPORATION

发明人： Han-Oh PARK ,  Sung II YUN ,  Sang-Jin BYUN ,  Myeong-Mi LEE ,  Seung Ya YANG

IPC分类号： A61K47/26 ,  A61K47/60 ,  A61K47/58 ,  A61K47/59 ,  A61K31/713 ,  A61Q7/00 ,  A61K8/60 ,  A61K8/86 ,  A61K8/88 ,  A61K8/84 ,  A61K8/81 ,  A61P17/14

摘要： Disclosed are a double stranded oligonucleotide construct, configured such that a hydrophilic material and a hydrophobic material are conjugated through a simple covalent bond or a linker-mediated covalent bond to both ends of a double stranded oligonucleotide in order to efficiently deliver an androgen-receptor-specific oligonucleotide into a cell, a nanoparticle capable of being produced by self-assembling double stranded oligonucleotide constructs in an aqueous solution through hydrophobic interactions, and a composition for preventing hair loss or promoting hair growth containing the double stranded oligonucleotide construct. The double stranded oligonucleotide construct including the androgen-receptor-specific oligonucleotide and the composition for preventing hair loss or promoting hair growth containing the same as an active ingredient can suppress the expression of an androgen receptor with high efficiency without side effects, and can thus exhibit excellent effects on preventing hair loss, particularly androgenetic alopecia, alopecia areata, and telogen effluvium, and promoting hair growth.