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公开(公告)号:US20230203491A1
公开(公告)日:2023-06-29
申请号:US17999399
申请日:2021-05-21
Applicant: BIONEER CORPORATION , SIRNAGEN THERAPEUTICS CORPORATION
Inventor: Han-Oh PARK , Jangseon KIM , Mi Sun LEE , Soonja CHOI , Eun-Kwang LEE , Sang Jin BYUN
IPC: C12N15/113 , A61K9/51 , A61P31/14 , A61P11/00 , A61K31/713
CPC classification number: C12N15/1131 , A61K9/51 , A61P31/14 , A61P11/00 , A61K31/713 , C12N2310/3235 , C12N2310/3231 , C12N2310/315 , C12N2310/312 , C12N2310/14 , C12N2320/32
Abstract: The present invention relates to: a double-stranded oligonucleotide which can highly specifically and efficiently inhibit the proliferation of Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), preferably a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or a DNA/RNA hybrid; a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide; and a use thereof for treating COVID-19.
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公开(公告)号:US20230123164A1
公开(公告)日:2023-04-20
申请号:US17907432
申请日:2021-04-12
Applicant: BIONEER CORPORATION , SIRNAGEN THERAPEUTICS CORPORATION , SOONCHUNHYANG UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION
Inventor: Seung Seob SON , Tae Rim KIM , Eun Young LEE , Nam-Jun CHO , Sung Il YUN , Jun Hong PARK , Han-Oh PARK
Abstract: The present invention relates to a composition using a urine sample for diagnosis of a kidney disease and, more specifically, to a urine test composition and a kit for diagnosis of a kidney disease, each comprising an agent specifically detecting amphiregulin from a urine sample, and a method for diagnosing a kidney disease by using the composition. According to the present invention, not only is there an advantage of being able to conveniently diagnose a kidney disease in a non-invasive manner using a urine sample for a kidney disease to which early diagnosis is important, but also the application of the present invention to a patient diagnosed with chronic kidney disease can advantageously predict the plausibility of progression into end-stage renal disease in advance.
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公开(公告)号:US20220118093A1
公开(公告)日:2022-04-21
申请号:US17297193
申请日:2019-11-18
Applicant: BIONEER CORPORATION
Inventor: Han-Oh PARK , Sung II YUN , Sang-Jin BYUN , Myeong-Mi LEE , Seung Ya YANG
IPC: A61K47/26 , A61K47/60 , A61K47/58 , A61K47/59 , A61K31/713 , A61Q7/00 , A61K8/60 , A61K8/86 , A61K8/88 , A61K8/84 , A61K8/81 , A61P17/14
Abstract: Disclosed are a double stranded oligonucleotide construct, configured such that a hydrophilic material and a hydrophobic material are conjugated through a simple covalent bond or a linker-mediated covalent bond to both ends of a double stranded oligonucleotide in order to efficiently deliver an androgen-receptor-specific oligonucleotide into a cell, a nanoparticle capable of being produced by self-assembling double stranded oligonucleotide constructs in an aqueous solution through hydrophobic interactions, and a composition for preventing hair loss or promoting hair growth containing the double stranded oligonucleotide construct. The double stranded oligonucleotide construct including the androgen-receptor-specific oligonucleotide and the composition for preventing hair loss or promoting hair growth containing the same as an active ingredient can suppress the expression of an androgen receptor with high efficiency without side effects, and can thus exhibit excellent effects on preventing hair loss, particularly androgenetic alopecia, alopecia areata, and telogen effluvium, and promoting hair growth.
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公开(公告)号:US20210388436A1
公开(公告)日:2021-12-16
申请号:US17286483
申请日:2019-10-21
Applicant: BIONEER CORPORATION
Inventor: Han-Oh PARK , Taewoo KWON , Sang Ryoung PARK
IPC: C12Q1/6876
Abstract: The present invention relates to a probe having octamine or octamine derivative bound thereto in addition to a reporter and a quencher to thus allow the quencher to more effectively suppress light emitted by the reporter, and to uses of the probe. When the probe according to the present invention is utilized, octamine or octamine derivative bound to the probe effectively suppresses the light emitted by the quencher for the reporter, and results in effects such as i) a reduction in base fluorescence, ii) an increase in delta fluorescence, and iii) a decrease in the value of cycle at threshold, thus allowing the probe to be effectively used in a variety of real-time polymerase chain reactions requiring accuracy and sensitivity.
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公开(公告)号:US20210168909A1
公开(公告)日:2021-06-03
申请号:US15734197
申请日:2019-05-31
Applicant: BIONEER CORPORATION
Inventor: Han-Oh PARK , Jae-Ha KIM , Jun Pyo KIM , Jieun KIM
IPC: H05B3/14 , H05B1/02 , A47J36/04 , A47J37/10 , C09D101/28
Abstract: An electric roasting pan according to the present invention comprises: a roasting pan; a heating layer being in surface contact with the roasting pan and comprising a carbon nanotube and a silicone-based adhesive; and an electrode in contact with the heating layer. The electric roasting pan has excellent thermal efficiency thanks to the minimal heat loss thereof, can reach a target temperature within a short time to reduce a preheating time, and affords excellent cooking quality. Furthermore, the electric roasting pan can substantially prevent the occurrence of temperature deviation across the area of the roasting pan during a temperature increase and is of high durability and safety.
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公开(公告)号:US20250066787A1
公开(公告)日:2025-02-27
申请号:US18281251
申请日:2022-03-08
Applicant: BIONEER CORPORATION , SIRNAGEN THERAPEUTICS CORPORATION
Inventor: Han-Oh PARK , Sang-Kyu LEE , Sung-ll YUN , Oh Seung KWON , Eun-Ah GOH , Young-Ho GOH , Jun-Hong PARK , Kang SONG , Jangseon KIM , Mi-Sun LEE , Soon-Ja CHOI
IPC: C12N15/113 , A61K9/00 , A61P31/14
Abstract: The present invention relates to a composition for administering a double-stranded oligonucleotide structure using an ultrasonic nebulizer. According to the method, the double-stranded oligonucleotide according to the present invention forms self-assembled nanoparticles, which are 90 nm in size and have a neutral charge, and it is possible to deliver the double-stranded oligonucleotide specifically to the nasal cavity and lungs while maintaining not only the same concentration, molecular weight, purity, nanoparticle size, and osmolality as those of the stock material but also the target gene inhibitory activity without cytotoxicity. Thus, the present invention may be useful for the prevention or treatment of respiratory viral infections including COVID-19, pulmonary fibrosis caused by viral infection, or respiratory diseases.
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公开(公告)号:US20230332154A1
公开(公告)日:2023-10-19
申请号:US18330853
申请日:2023-06-07
Applicant: Bioneer Corporation
Inventor: Tae-Rim KIM , Pyoung Oh YOON , Youngho KO , Seon Joo BAE , Han-Oh PARK , Seung Seob SON , Jun-Hong PARK , Sung-Il YUN
IPC: C12N15/113 , A61P11/00 , A61K9/19 , A61K31/713
CPC classification number: C12N15/1136 , A61P11/00 , A61K9/19 , A61K31/713 , C12N2310/14 , C12N2310/314 , C12N2310/322 , C12N2310/351 , C12N2310/3515
Abstract: The present invention relates to a double-stranded oligonucleotide which can highly specifically and efficiently inhibit an amphiregulin expression and, preferably, a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or DNA/RNA hybrid, a double-stranded oligonucleotide structure comprising the double-stranded oligonucleotide, nanoparticles comprising the double-stranded oligonucleotide structure, and a fibrosis or respiratory disease preventive or therapeutic use thereof.
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公开(公告)号:US20220074898A1
公开(公告)日:2022-03-10
申请号:US17309868
申请日:2019-10-24
Applicant: BIONEER CORPORATION
Inventor: Han-Oh PARK , Taeman KIM , Jong Rok AHN , Jae-Ha KIM
Abstract: A heater integrated gas chromatography (GC) column device according to the present invention is capable of precisely and uniformly controlling a temperature by having a high thermal conductivity, and raising and lowering a temperature at a high speed by having a low thermal mass, such that a measuring time is significantly decreased. The GC column is in contact with a bobbin with a homogeneous temperature distribution, and thus a temperature is homogeneously distributed in each GC column. Further, the heater integrated GC column device according to the present invention has the above-described effects and may have a smaller size.
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公开(公告)号:US20210233759A1
公开(公告)日:2021-07-29
申请号:US15734848
申请日:2019-06-04
Applicant: BIONEER CORPORATION
Inventor: Taeman KIM , Han-Oh PARK
Abstract: An ion guide for transferring ions to a mass analyzer is disclosed. The ion guide is characterized in that a plurality of DC rings and a plurality of RF multi-pole rings with a plurality of electrodes are arranged alternatingly along a central axis between an inlet into which the ions move and an outlet for transferring the ions. The inner diameter of the DC rings is kept constant and the inner diameter of the RF multi-pole rings gradually decreases in a direction from the inlet to the outlet.
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公开(公告)号:US20230348912A1
公开(公告)日:2023-11-02
申请号:US17998662
申请日:2021-05-13
Applicant: BIONEER CORPORATION , SIRNAGEN THERAPEUTICS CORPORATION
Inventor: Jun Hong PARK , Han-Oh PARK , Sung Il YUN , Tae Rim KIM , Soo Hyun HWANG , Kang SONG , Sang Hyuk JUNG , Jangseon KIM , Mi Sun LEE , Soonja CHOI , Seung Seob SON
IPC: C12N15/113 , A61K48/00 , A61K47/60 , A61K47/69 , A61P3/04
CPC classification number: C12N15/1136 , A61K48/0025 , A61K47/60 , A61K47/6929 , A61P3/04
Abstract: The present invention relates to a double-stranded oligonucleotide capable of inhibiting amphiregulin expression in a very specific and highly efficient manner, preferably a double-stranded oligonucleotide comprising a sequence in the form of an RNA/RNA, DNA/DNA or DNA/RNA hybrid, and the use of a double-stranded oligonucleotide structure, which comprises the double-stranded oligonucleotide, and nanoparticles, for preventing or treating obesity.
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