公开(公告)号：US20220088051A1

公开(公告)日：2022-03-24

申请号：US17423372

申请日：2020-01-15

申请人： BIONEER CORPORATION

发明人： Han-Oh PARK ,  Sung II YUN ,  Sang-Jin BYUN ,  Pyoung Oh YOON ,  Sang-Kyu LEE ,  Tae-Rim KIM ,  Young-Ho KO ,  Seung-Seob SON ,  Eun-Ah GOH ,  Hyung-Jin KIM

IPC分类号： A61K31/713 ,  A61P17/14

摘要： The present invention pertains to: a double-stranded oligonucleotide construct having a structure in which a hydrophilic substance and a hydrophobic substance are conjugated by a simple covalent bond or a linker-mediated covalent bond at both ends of a DKK1-specific double-stranded oligonucleotide to efficiently deliver the double-stranded oligonucleotide into cells; a nanoparticle capable of being produced through self-assembly of the double-stranded oligonucleotide construct through a hydrophobic interaction in an aqueous solution; and a hair-loss-preventing and hair-growth-promoting composition containing the double-stranded oligonucleotide construct or the nanoparticle. A double-stranded oligonucleotide construct including a DKK1-specific double-stranded oligonucleotide, a nanoparticle, and a hair loss prevention or hair growth composition containing the double-stranded oligonucleotide construct or the nanoparticle as an active ingredient according to the present invention very efficiently suppress the expression of DKK1 without side effects and are remarkably effective for preventing hair loss and promoting hair growth, and can thus be very usefully used for a composition for preventing hair loss and promoting hair growth.

公开(公告)号：US20220118093A1

公开(公告)日：2022-04-21

申请号：US17297193

申请日：2019-11-18

申请人： BIONEER CORPORATION

发明人： Han-Oh PARK ,  Sung II YUN ,  Sang-Jin BYUN ,  Myeong-Mi LEE ,  Seung Ya YANG

IPC分类号： A61K47/26 ,  A61K47/60 ,  A61K47/58 ,  A61K47/59 ,  A61K31/713 ,  A61Q7/00 ,  A61K8/60 ,  A61K8/86 ,  A61K8/88 ,  A61K8/84 ,  A61K8/81 ,  A61P17/14

摘要： Disclosed are a double stranded oligonucleotide construct, configured such that a hydrophilic material and a hydrophobic material are conjugated through a simple covalent bond or a linker-mediated covalent bond to both ends of a double stranded oligonucleotide in order to efficiently deliver an androgen-receptor-specific oligonucleotide into a cell, a nanoparticle capable of being produced by self-assembling double stranded oligonucleotide constructs in an aqueous solution through hydrophobic interactions, and a composition for preventing hair loss or promoting hair growth containing the double stranded oligonucleotide construct. The double stranded oligonucleotide construct including the androgen-receptor-specific oligonucleotide and the composition for preventing hair loss or promoting hair growth containing the same as an active ingredient can suppress the expression of an androgen receptor with high efficiency without side effects, and can thus exhibit excellent effects on preventing hair loss, particularly androgenetic alopecia, alopecia areata, and telogen effluvium, and promoting hair growth.

公开(公告)号：US20130157275A1

公开(公告)日：2013-06-20

申请号：US13782796

申请日：2013-03-01

申请人： BIONEER CORPORATION

发明人： Han Oh PARK ,  Jae-Don LEE ,  Gu-Young SONG ,  Jong Wak OH ,  Hyun-Bae KIM ,  Sang-Jin BYUN ,  Jin-Wong JANG ,  Won-Seok JANG ,  Jong-Deok CHOI

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： G01N33/58 ,  C12Q1/68 ,  C12Q2531/113 ,  C12Q2561/113 ,  C12Q2563/185

摘要： Provided are an oligonucleotide marker and a method of identifying a material using the same. The oligonucleotide marker makes it possible to analyze a trace amount of the material with high precision within a short time, has improved solubility in an oily solvent, and can improve a detection method such that the oligonucleotide marker can be detected within 2 hours. The oligonucleotide marker can label various products, including oil products and petroleum products, works of art and collections, and can also be used to conduct criminal investigations.

摘要翻译： 提供寡核苷酸标记物和识别使用其的材料的方法。 寡核苷酸标记使得可以在短时间内高精度地分析痕量的材料，在油性溶剂中的溶解性提高，并且可以改进检测方法，使得可以在2小时内检测寡核苷酸标记。 寡核苷酸标记可以标注各种产品，包括石油产品和石油产品，艺术品和收藏品，也可用于进行刑事调查。