公开(公告)号：US11220489B2

公开(公告)日：2022-01-11

申请号：US16328447

申请日：2017-08-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Junying Fan ,  Peng Geng ,  Neil A. Strotman ,  Alina Borovika ,  Jason Michael Stevens ,  Dimitri Skliar

IPC: C07D401/04

Abstract: Disclosed is a process for preparing (S)-4-(3-(but-2-ynamido)piperidin fluoro-2,3-dimethyl-1H-indole-7-carboxamide, comprising the steps of: preparing a compound of Formula (III); converting the compound of Formula (III) to a compound of Formula (V); and reacting the compound of Formula (V) with a compound of Formula (VI) to provide (S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide.

公开(公告)号：US20220298122A1

公开(公告)日：2022-09-22

申请号：US17603659

申请日：2020-04-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Richard J. Fox ,  Carlos A. Guerrero ,  Michael Dummeldinger ,  Dimitri Skliar ,  Harshkumar Patel ,  Yichen Tan ,  David Thomas George

IPC: C07D249/04 ,  C07C51/09 ,  C07C51/12 ,  C07C51/29 ,  C07D401/04 ,  C07D233/60

Abstract: Improved methods and intermediates thereof for preparing carbamoyloxy methyl triazole cyclohexyl acid compounds are described. These compounds are useful as LPA antagonists. Formula (I).

公开(公告)号：US20210276970A1

公开(公告)日：2021-09-09

申请号：US16328447

申请日：2017-08-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Junying Fan ,  Peng Geng ,  Neil A. Strotman ,  Alina Borovika ,  Jason Michael Stevens ,  Dimitri Skliar

IPC: C07D401/04

Abstract: Disclosed is a process for preparing (S)-4-(3-(but-2-ynamido)piperidin fluoro-2,3-dimethyl-1H-indole-7-carboxamide, comprising the steps of: preparing a compound of Formula (III); converting the compound of Formula (III) to a compound of Formula (V); and reacting the compound of Formula (V) with a compound of Formula (VI) to provide (S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide.