公开(公告)号：US20230250053A1

公开(公告)日：2023-08-10

申请号：US18003227

申请日：2021-06-22

Applicant: Bristol-Myers Squibb Company

Inventor： Zhongping Shi ,  Yichen Tan ,  Federico Lora Gonzalez ,  Ronald Carrasquillo-Flores ,  Michael J. Smith

IPC: C07C271/20 ,  C07C233/38 ,  C07C269/04 ,  C07C231/14

CPC classification number: C07C271/20 ,  C07C233/38 ,  C07C269/04 ,  C07C231/14

Abstract: The present application provides processes for synthesizing targeting molecules of Formula (I) comprising a retinoid moiety useful in the synthesis of fat-soluble compounds for targeting and enhancing activity of therapeutic molecules, including siRNA.

公开(公告)号：US20220298122A1

公开(公告)日：2022-09-22

申请号：US17603659

申请日：2020-04-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Richard J. Fox ,  Carlos A. Guerrero ,  Michael Dummeldinger ,  Dimitri Skliar ,  Harshkumar Patel ,  Yichen Tan ,  David Thomas George

IPC: C07D249/04 ,  C07C51/09 ,  C07C51/12 ,  C07C51/29 ,  C07D401/04 ,  C07D233/60

Abstract: Improved methods and intermediates thereof for preparing carbamoyloxy methyl triazole cyclohexyl acid compounds are described. These compounds are useful as LPA antagonists. Formula (I).

公开(公告)号：US20210395200A1

公开(公告)日：2021-12-23

申请号：US17292123

申请日：2019-11-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adrian Ortiz ,  Alina Borovika ,  Sergei Kolotuchin ,  Michael R. Luzung ,  Jeffrey A. Nye ,  Yichen Tan ,  Serge Zaretsky ,  Jason J. Zhu ,  Martin D. Eastgate

IPC: C07D207/273

Abstract: Highly efficient processes are provided for preparing key intermediates in the synthesis of compounds (I). The process are broadly applicable and can provide selected components having a variety of substituents. Some intermediates are claimed.