公开(公告)号：US10106560B2

公开(公告)日：2018-10-23

申请号：US15623570

申请日：2017-06-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adrian Ortiz ,  Carlos A. Guerrero ,  Bin Zheng ,  Jason J. Zhu ,  Michael Anthony Schmidt ,  Michael R. Luzung ,  Martin D. Eastgate

IPC: C07D417/12 ,  C07F7/18 ,  C07D211/28 ,  C07F7/08

Abstract: An improved process for making a compound B of the structure wherein n, R1, R2, and R3 are as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.

公开(公告)号：US20220298122A1

公开(公告)日：2022-09-22

申请号：US17603659

申请日：2020-04-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Richard J. Fox ,  Carlos A. Guerrero ,  Michael Dummeldinger ,  Dimitri Skliar ,  Harshkumar Patel ,  Yichen Tan ,  David Thomas George

IPC: C07D249/04 ,  C07C51/09 ,  C07C51/12 ,  C07C51/29 ,  C07D401/04 ,  C07D233/60

Abstract: Improved methods and intermediates thereof for preparing carbamoyloxy methyl triazole cyclohexyl acid compounds are described. These compounds are useful as LPA antagonists. Formula (I).

公开(公告)号：US11332442B2

公开(公告)日：2022-05-17

申请号：US16991357

申请日：2020-08-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： William P. Gallagher ,  John Ryan Coombs ,  Carlos A. Guerrero ,  David Marcoux ,  Qing Shi ,  Candice Lee Joe ,  Sanjeewa Rupasinghe ,  Jason J. Zhu ,  Srinivas Kalidindi ,  Sathasivam Shunmugaraj ,  Moorthy Kandasamy ,  Siva Sankar Bondigela ,  Rajappa Vaidyanathan ,  Shankar Tulsidas Tendulkar ,  Sankar Kuppusamy ,  Francisco González-Bobes

IPC: C07D209/60 ,  C07C315/04 ,  C07C303/40 ,  C07C311/03 ,  C07C317/24

Abstract: The invention generally relates to a process for preparing compounds, including Compound of Formula (I), useful as key intermediates in the preparation of compounds having RORγt antagonist properties.