公开(公告)号：US11220489B2

公开(公告)日：2022-01-11

申请号：US16328447

申请日：2017-08-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Junying Fan ,  Peng Geng ,  Neil A. Strotman ,  Alina Borovika ,  Jason Michael Stevens ,  Dimitri Skliar

IPC: C07D401/04

Abstract: Disclosed is a process for preparing (S)-4-(3-(but-2-ynamido)piperidin fluoro-2,3-dimethyl-1H-indole-7-carboxamide, comprising the steps of: preparing a compound of Formula (III); converting the compound of Formula (III) to a compound of Formula (V); and reacting the compound of Formula (V) with a compound of Formula (VI) to provide (S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide.

公开(公告)号：US20210276970A1

公开(公告)日：2021-09-09

申请号：US16328447

申请日：2017-08-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Junying Fan ,  Peng Geng ,  Neil A. Strotman ,  Alina Borovika ,  Jason Michael Stevens ,  Dimitri Skliar

IPC: C07D401/04

Abstract: Disclosed is a process for preparing (S)-4-(3-(but-2-ynamido)piperidin fluoro-2,3-dimethyl-1H-indole-7-carboxamide, comprising the steps of: preparing a compound of Formula (III); converting the compound of Formula (III) to a compound of Formula (V); and reacting the compound of Formula (V) with a compound of Formula (VI) to provide (S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide.

公开(公告)号：US20210078980A1

公开(公告)日：2021-03-18

申请号：US17101411

申请日：2020-11-23

Applicant: Bristol-Myers Squibb Company

Inventor： Ronald Carrasquillo ,  Peng Geng ,  Eric C. Huang ,  Kishta Katipally ,  Andrew Lee ,  Boguslaw Mudryk ,  Xinhua Qian ,  Thomas M. Razler ,  Jianji Wang ,  Carolyn S. Wei ,  Steven R. Wisniewski ,  Ye Zhu

IPC: C07D403/10

Abstract: Disclosed is a process for preparing Compound 8: comprising the step of reacting Compound of 7: wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.

公开(公告)号：US11591314B2

公开(公告)日：2023-02-28

申请号：US17101411

申请日：2020-11-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ronald Carrasquillo ,  Peng Geng ,  Eric C. Huang ,  Kishta Katipally ,  Andrew Lee ,  Boguslaw Mudryk ,  Xinhua Qian ,  Thomas M. Razler ,  Jianji Wang ,  Carolyn S. Wei ,  Steven R. Wisniewski ,  Ye Zhu

IPC: C07D403/10

Abstract: Disclosed is a process for preparing Compound 8: comprising the step of reacting Compound of 7: wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.