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![1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS](/abs-image/US/2023/04/27/US20230131192A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230131192A1
公开(公告)日：2023-04-27
申请号：US17793155
申请日：2021-01-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Christine M. TARBY , Matthias BROEKEMA , Ashvinikumar V. GAVAI , Sanjeev GANGWAR , Naidu S. CHOWDARI , Walter L JOHNSON , Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH
IPC: C07D487/04 , A61K45/06
Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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