公开(公告)号：US20230144824A1

公开(公告)日：2023-05-11

申请号：US17793248

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Liqi HE ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Qiang CONG ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM ,  Christine M. TARBY ,  Patrice GILL ,  Andrew F. DONNELL ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Compounds according to formula I or II are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230041738A1

公开(公告)日：2023-02-09

申请号：US17793174

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Matthew COX ,  Liqi HE ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Mathias BROEKEMA ,  Christine M. TARBY ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC: A61K31/519 ,  C07D519/00 ,  C07D487/04 ,  A61K31/5386 ,  A61K39/395

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230348468A1

公开(公告)日：2023-11-02

申请号：US17793278

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Matthew COX ,  Naidu S. CHOWDARI ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Christine M. TARBY ,  Yam B. POUDEL ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC: C07D487/04 ,  C07K16/28

CPC classification number: C07D487/04 ,  C07K16/2818 ,  C07K16/2827

Abstract: Compounds according to formula I or II are useful as agonists of Toll-like receptor 7 (TLR7). (I) (II) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230131192A1

公开(公告)日：2023-04-27

申请号：US17793155

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Christine M. TARBY ,  Matthias BROEKEMA ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Naidu S. CHOWDARI ,  Walter L JOHNSON ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC: C07D487/04 ,  A61K45/06

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20210070698A1

公开(公告)日：2021-03-11

申请号：US16959487

申请日：2019-01-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James Aaron BALOG ,  Steven P. SEITZ ,  David K. WILLIAMS ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC: C07C275/42

Abstract: The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.