公开(公告)号：US20230140430A1

公开(公告)日：2023-05-04

申请号：US17792887

申请日：2021-01-26

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Matthew COX ,  Liqi HE ,  Sanjeev GANGWAR ,  Ashvinikumar V. GAVAI ,  Matthias BROEKEMA ,  Qiang CONG ,  Daniel O'MALLEY ,  Yam B. POUDEL ,  Christine M. TARBY

IPC分类号： C07D519/00 ,  A61K45/06

摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230127326A1

公开(公告)日：2023-04-27

申请号：US17792905

申请日：2021-01-26

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Christine M. TARBY ,  Qiang CONG ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Matthias BROEKEMA ,  Patrice GILL ,  Prasanna SIVAPRAKASAM ,  Walter L. JOHNSON ,  Murugaiah Andappan Murugaiah SUBBAIAH ,  Yam B. POUDEL

IPC分类号： A61K31/519 ,  A61K39/395 ,  C07D487/04

摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230144824A1

公开(公告)日：2023-05-11

申请号：US17793248

申请日：2021-01-26

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Liqi HE ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Qiang CONG ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM ,  Christine M. TARBY ,  Patrice GILL ,  Andrew F. DONNELL ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： Compounds according to formula I or II are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230130516A1

公开(公告)日：2023-04-27

申请号：US17792878

申请日：2021-01-26

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Qian ZHANG ,  Sanjeev GANGWAR ,  Ashvinikumar V. GAVAI ,  Qiang CONG ,  Yam B. POUDEL ,  Liqi HE ,  Prasanna SIVAPRAKASAM ,  Christine M. TARBY

IPC分类号： A61K31/519 ,  C07D487/04 ,  C07D519/00 ,  A61K31/5377 ,  A61K39/395

摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230122249A1

公开(公告)日：2023-04-20

申请号：US17793162

申请日：2021-01-26

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Yam B. POUDEL ,  Matthew COX ,  Liqi HE ,  Daniel O'MALLEY ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Matthias BROEKEMA ,  Prasanna SIVAPRAKASAM ,  Christine M. TARBY ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH,Murugaiah

IPC分类号： C07D487/04 ,  C07D519/00

摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230041738A1

公开(公告)日：2023-02-09

申请号：US17793174

申请日：2021-01-26

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Yam B. POUDEL ,  Matthew COX ,  Liqi HE ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Mathias BROEKEMA ,  Christine M. TARBY ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC分类号： A61K31/519 ,  C07D519/00 ,  C07D487/04 ,  A61K31/5386 ,  A61K39/395

摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230348468A1

公开(公告)日：2023-11-02

申请号：US17793278

申请日：2021-01-26

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Matthew COX ,  Naidu S. CHOWDARI ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Christine M. TARBY ,  Yam B. POUDEL ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC分类号： C07D487/04 ,  C07K16/28

CPC分类号： C07D487/04 ,  C07K16/2818 ,  C07K16/2827

摘要： Compounds according to formula I or II are useful as agonists of Toll-like receptor 7 (TLR7). (I) (II) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230140047A1

公开(公告)日：2023-05-04

申请号：US18081558

申请日：2022-12-14

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： YAM B. POUDEL ,  Sanjeev GANGWAR ,  Liqi HE ,  Prasanna SIVAPRAKASAM ,  Matthias BROEKEMA ,  Matthew COX ,  Christine M. TARBY ,  Qian ZHANG ,  Naidu S. CHOWDARI

IPC分类号： A61K31/519 ,  A61K47/60 ,  A61K39/395 ,  C07D487/04 ,  A61P35/00 ,  A61K31/395

摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230131192A1

公开(公告)日：2023-04-27

申请号：US17793155

申请日：2021-01-26

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Christine M. TARBY ,  Matthias BROEKEMA ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Naidu S. CHOWDARI ,  Walter L JOHNSON ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC分类号： C07D487/04 ,  A61K45/06

摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230118688A1

公开(公告)日：2023-04-20

申请号：US17792869

申请日：2021-01-26

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Heng CHENG ,  Christine M. TARBY ,  Sanjeev GANGWAR ,  Ashvinikumar V. GAVAI ,  Walter L. JOHNSON ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM ,  Patrice GILL ,  Andrew F. DONNELL ,  Murugaiah Andappan Murugaiah SUBBAIAH

IPC分类号： A61K31/519 ,  C07D487/04 ,  A61K39/395

摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.