公开(公告)号：US08754230B2

公开(公告)日：2014-06-17

申请号：US14026628

申请日：2013-09-13

Applicant: Bristol-Myers Squibb Company

Inventor： Robert C. Livingston ,  William P. Gallagher ,  Robert M. Borzilleri ,  Zhen-Wei Cai

IPC: C07D211/72 ,  C07D213/74

CPC classification number: C07D213/74 ,  C07D213/63 ,  C07D401/12

Abstract: Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or an activated carboxylic acid compound thereof, to provide a compound of Formula (IV); and (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I); wherein PAm is a protected amine group. Processes to prepare the compounds of Formulae (II), (III), and (IV) are also disclosed.

Abstract translation: 本文公开了一种制备式（I）化合物的方法，包括以下步骤：（a）使式（II）的苯胺化合物与式（III）的羧酸化合物或其活化的羧酸化合物反应， 以提供式（IV）的化合物; 和（b）将所述与式（IV）化合物连接的受保护胺基转化为胺基，得到所述式（I）化合物; 其中PAm是受保护的胺基团。 还公开了制备式（II），（III）和（IV）化合物的方法。

公开(公告)号：US20160060252A1

公开(公告)日：2016-03-03

申请号：US14784460

申请日：2014-04-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： William P. Gallagher ,  Prashant P. Deshpande ,  Jun Li ,  Kishta Katipally

IPC: C07D405/04 ,  C07D493/04

CPC classification number: C07D405/04 ,  C07D493/04

Abstract: The NRTI compound festinavir is made using 5-methyluridine as a starting material, followed by Claisen rearrangement.

Abstract translation: 使用5-甲基尿苷作为起始原料制备NRTI化合物festinavir，接着是Claisen重排。

公开(公告)号：US20140012007A1

公开(公告)日：2014-01-09

申请号：US14026628

申请日：2013-09-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Robert C. Livingston ,  William P. Gallagher ,  Robert M. Borzilleri ,  Zhen-Wei Cai

IPC: C07D213/74

CPC classification number: C07D213/74 ,  C07D213/63 ,  C07D401/12

Abstract: Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or an activated carboxylic acid compound thereof, to provide a compound of Formula (IV); and (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I); wherein PAm is a protected amine group. Processes to prepare the compounds of Formulae (II), (III), and (IV) are also disclosed.

Abstract translation: 本文公开了一种制备式（I）化合物的方法，包括以下步骤：（a）使式（II）的苯胺化合物与式（III）的羧酸化合物或其活化的羧酸化合物反应， 以提供式（IV）的化合物; 和（b）将所述与式（IV）化合物连接的受保护胺基转化为胺基，得到所述式（I）化合物; 其中PAm是受保护的胺基团。 还公开了制备式（II），（III）和（IV）化合物的方法。

公开(公告)号：US11332442B2

公开(公告)日：2022-05-17

申请号：US16991357

申请日：2020-08-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： William P. Gallagher ,  John Ryan Coombs ,  Carlos A. Guerrero ,  David Marcoux ,  Qing Shi ,  Candice Lee Joe ,  Sanjeewa Rupasinghe ,  Jason J. Zhu ,  Srinivas Kalidindi ,  Sathasivam Shunmugaraj ,  Moorthy Kandasamy ,  Siva Sankar Bondigela ,  Rajappa Vaidyanathan ,  Shankar Tulsidas Tendulkar ,  Sankar Kuppusamy ,  Francisco González-Bobes

IPC: C07D209/60 ,  C07C315/04 ,  C07C303/40 ,  C07C311/03 ,  C07C317/24

Abstract: The invention generally relates to a process for preparing compounds, including Compound of Formula (I), useful as key intermediates in the preparation of compounds having RORγt antagonist properties.