公开(公告)号：US11591314B2

公开(公告)日：2023-02-28

申请号：US17101411

申请日：2020-11-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ronald Carrasquillo ,  Peng Geng ,  Eric C. Huang ,  Kishta Katipally ,  Andrew Lee ,  Boguslaw Mudryk ,  Xinhua Qian ,  Thomas M. Razler ,  Jianji Wang ,  Carolyn S. Wei ,  Steven R. Wisniewski ,  Ye Zhu

IPC: C07D403/10

Abstract: Disclosed is a process for preparing Compound 8: comprising the step of reacting Compound of 7: wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.

公开(公告)号：US20210078980A1

公开(公告)日：2021-03-18

申请号：US17101411

申请日：2020-11-23

Applicant: Bristol-Myers Squibb Company

Inventor： Ronald Carrasquillo ,  Peng Geng ,  Eric C. Huang ,  Kishta Katipally ,  Andrew Lee ,  Boguslaw Mudryk ,  Xinhua Qian ,  Thomas M. Razler ,  Jianji Wang ,  Carolyn S. Wei ,  Steven R. Wisniewski ,  Ye Zhu

IPC: C07D403/10

Abstract: Disclosed is a process for preparing Compound 8: comprising the step of reacting Compound of 7: wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.

公开(公告)号：US20160060252A1

公开(公告)日：2016-03-03

申请号：US14784460

申请日：2014-04-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： William P. Gallagher ,  Prashant P. Deshpande ,  Jun Li ,  Kishta Katipally

IPC: C07D405/04 ,  C07D493/04

CPC classification number: C07D405/04 ,  C07D493/04

Abstract: The NRTI compound festinavir is made using 5-methyluridine as a starting material, followed by Claisen rearrangement.

Abstract translation: 使用5-甲基尿苷作为起始原料制备NRTI化合物festinavir，接着是Claisen重排。