公开(公告)号：US10995049B2

公开(公告)日：2021-05-04

申请号：US16922290

申请日：2020-07-07

Applicant: California Institute of Technology

Inventor： Jiaming Li ,  Chen Xu ,  Tonia S Ahmed ,  Robert H Grubbs ,  Brian M. Stoltz

IPC: C07C45/29 ,  C07C29/00 ,  C07C49/557 ,  C07C49/577

Abstract: The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R1 is defined in the specification

公开(公告)号：US09382387B2

公开(公告)日：2016-07-05

申请号：US13800646

申请日：2013-03-13

Applicant: California Institute of Technology ,  The University of Massachusetts

Inventor： Yan Xia ,  Benjamin R Sveinbjornsson ,  Robert H Grubbs ,  Raymond Weitekamp ,  Garret M Miyake ,  Harry A Atwater ,  Victoria Piunova ,  Christopher Scot Daeffler ,  Sung Woo Hong ,  Weiyin Gu ,  Thomas P. Russell

IPC: C08G81/02 ,  C08G83/00

CPC classification number: C08G81/027 ,  C08G83/008

Abstract: The invention provides a class of copolymers having useful properties, including brush block copolymers, wedge-type block copolymers and hybrid wedge and polymer block copolymers. In an embodiment, for example, block copolymers of the invention incorporate chemically different blocks comprising polymer size chain groups and/or wedge groups that significantly inhibit chain entanglement, thereby enhancing molecular self-assembly processes for generating a range of supramolecular structures, such as periodic nanostructures and microstructures. The present invention also provides useful methods of making and using copolymers, including block copolymers.

Abstract translation: 本发明提供一类具有有用性质的共聚物，包括刷嵌嵌段共聚物，楔型嵌段共聚物和混合楔形和聚合物嵌段共聚物。 在一个实施方案中，例如，本发明的嵌段共聚物包含化学上不同的嵌段，其包含显着抑制链缠结的聚合物尺寸链基团和/或楔形基团，从而增强分子自组装方法以产生一系列超分子结构，例如周期性 纳米结构和微结构。 本发明还提供制备和使用包括嵌段共聚物的共聚物的有用方法。

公开(公告)号：US11053356B2

公开(公告)日：2021-07-06

申请号：US15914762

申请日：2018-03-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Robert H Grubbs ,  Tzu-Pin Lin ,  Alice Chang ,  Hsiang-Yun Chen ,  Christopher M Bates

IPC: C08G81/00 ,  C08G81/02 ,  C08F285/00 ,  C08F287/00 ,  C08G61/08 ,  C08F290/04 ,  C08F290/06 ,  C08F290/02 ,  C08F267/10 ,  B82Y40/00 ,  C08F293/00

Abstract: In an aspect, a method of synthesizing a graft copolymer comprises the steps of: copolymerizing a first macromonomer and a first reactive diluent; wherein said first macromonomer comprises a first backbone precursor directly or indirectly covalently linked to a first polymer side chain group; wherein said reactive diluent is provided in the presence of the first macromonomer at an amount selected so as to result in formation said graft copolymer having a first backbone incorporating said diluent and said first macromonomer in a first polymer block characterized by a preselected first graft density or a preselected first graft distribution of said first macromonomer. In some embodiments of this aspect, said preselected first graft density is any value selected from the range of 0.05 to 0.75. In some methods, the composition and amount of said diluent is selected to provide both a first preselected first graft density and a first preselected first graft distribution.

公开(公告)号：US09453943B2

公开(公告)日：2016-09-27

申请号：US13930400

申请日：2013-06-28

Applicant: California Institute of Technology

Inventor： Garret M Miyake ,  Raymond Weitekamp ,  Robert H Grubbs ,  Victoria Piunova

IPC: G02B1/00 ,  C08F293/00 ,  C08F297/00 ,  C08F222/40 ,  C08F299/00 ,  C08F222/04 ,  C08G81/00

CPC classification number: G02B1/005 ,  C08F222/04 ,  C08F222/40 ,  C08F293/00 ,  C08F299/00 ,  C08G81/00 ,  C08L87/005 ,  G02F1/0054 ,  G02F2202/32

Abstract: The invention provides a class of block copolymers having a plurality of chemically different blocks, at least a portion of which incorporating polymer side chain groups having a helical secondary structure. The invention also provides structures generated by self-assembly of polymer blends including at least one block copolymer component, such as a brush block polymer or wedge-type block polymer. The invention provides, for example, periodic nanostructures and microstructures generated by self-assembly of block copolymers and polymer blends comprising a mixture of at least one block copolymer component, such as a brush block copolymer, and at least a second component.

Abstract translation: 本发明提供了一类具有多个化学上不同的嵌段的嵌段共聚物，其至少一部分结合了具有螺旋二级结构的聚合物侧链基团。 本发明还提供通过包括至少一种嵌段共聚物组分如刷嵌聚合物或楔形嵌段聚合物的聚合物共混物的自组装产生的结构。 本发明提供了例如通过嵌段共聚物和包含至少一种嵌段共聚物组分如刷嵌段共聚物和至少第二组分的混合物的聚合物共混物自组装产生的周期性纳米结构和微结构。