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公开(公告)号：US20150361100A1
公开(公告)日：2015-12-17
申请号：US14741965
申请日：2015-06-17
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Matteo BIAGETTI , Alessandro ACCETTA , Anna Maria CAPELLI , Matilde GUALA , Michele RETINI
IPC: C07D519/00 , C07D471/04 , A61K31/519 , A61K31/497 , A61K31/5377 , A61K31/52 , A61K31/506
CPC classification number: C07D519/00 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D471/04 , C07D473/02 , C07D487/04 , Y02A50/409
Abstract: Compounds of formula (I), defined herein, inhibit phosphoinositide 3-kinases (PI3K) and are useful for the treatment of disorders associated with PI3K enzymes.
Abstract translation: 本文定义的式（I）化合物抑制磷酸肌醇3-激酶（PI3K），可用于治疗与PI3K酶相关的疾病。
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公开(公告)号：US20240082223A1
公开(公告)日：2024-03-14
申请号：US18267202
申请日：2021-12-13
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Fabio RANCATI , Alessandro ACCETTA , Anna Maria CAPELLI , Daniele PALA , Roberta MAZZUCATO , Christine EDWARDS , Adele Elisa PASQUA
IPC: A61K31/4355 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D491/048 , C07D519/00
CPC classification number: A61K31/4355 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D491/048 , C07D519/00
Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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公开(公告)号：US20160303123A1
公开(公告)日：2016-10-20
申请号：US15079740
申请日：2016-03-24
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Anna Maria CAPELLI , Matteo BIAGETTI , Alessandro ACCETTA
IPC: A61K31/506 , A61K31/519 , A61K31/52 , C07D487/04 , C07D405/12 , C07D473/34
CPC classification number: A61K31/506 , A61K31/519 , A61K31/52 , C07D403/12 , C07D405/12 , C07D473/34 , C07D487/04
Abstract: Chromene compounds of formula (I), defined herein, inhibit phosphoinositide 3-kinases (PI3K) and are useful for the treatment of disorders associated with a PI3K enzyme mechanism, such as asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis.
Abstract translation: 本文定义的式（I）的色烯化合物抑制磷酸肌醇3-激酶（PI3K），并且可用于治疗与PI3K酶机制相关的疾病，例如哮喘，慢性阻塞性肺病和特发性肺纤维化。
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公开(公告)号：US20240092790A1
公开(公告)日：2024-03-21
申请号：US18267177
申请日：2021-12-13
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Fabio RANCATI , Alessandro ACCETTA , Anna Maria CAPELLI , Daniele PALA , Christine EDWARDS , Adele Elisa PASQUA , Prashant Bhimrao KAPADNIS , Arnaud Jean Francois Auguste CHEGUILLAUME , David Edward CLARK
IPC: C07D491/048
CPC classification number: C07D491/048
Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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公开(公告)号：US20210284639A1
公开(公告)日：2021-09-16
申请号：US17260631
申请日：2019-07-12
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Alessandro ACCETTA , Fabio RANCATI , Anna Maria CAPELLI , David Edward CLARK , Patrizia TISSELLI , Christine EDWARDS , Amaud Jean Francois Auguste CHEGUILLAUME , Gurdip BHALAY
IPC: C07D471/04 , A61K9/00 , A61K31/437 , A61K45/06 , C07D519/00 , A61K31/496 , C07D487/04 , A61K31/519
Abstract: The invention relates to compounds of formula I inhibiting Rho Kinase that are bicyclic dihydropyrimidine-carboxamide derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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Patent Agency Ranking
公开(公告)号：US20170226109A1
公开(公告)日：2017-08-10
申请号：US15420513
申请日：2017-01-31
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Matteo BIAGETTI , Anna Maria CAPELLI , Michele RETINI
IPC: C07D487/04 , A61K31/519 , A61K45/06
CPC classification number: C07D487/04 , A61K31/519 , A61K45/06
Abstract: Compounds of formula (I) defined herein are phosphoinositide 3-kinases (PI3K) inhibitors and are useful for the treatment of disorders associated with PI3K enzymes.
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公开(公告)号：US20240092792A1
公开(公告)日：2024-03-21
申请号：US18267222
申请日：2021-12-13
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Fabio RANCATI , Alessandro ACCETTA , Anna Maria CAPELLI , Daniele PALA , Christine EDWARDS , Adele Elisa PASQUA , Prashant Bhimrao KAPADNIS , Arnaud Jean Francois Auguste CHEGUILLAUME
IPC: C07D491/048 , A61K45/06 , C07D519/00
CPC classification number: C07D491/048 , A61K45/06 , C07D519/00
Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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公开(公告)号：US20240092791A1
公开(公告)日：2024-03-21
申请号：US18267185
申请日：2021-12-13
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Fabio RANCATI , Alessandro ACCETTA , Anna Maria CAPELLI , Daniele PALA , Christine EDWARDS , Adele Elisa PASQUA , Prashant Bhimrao KAPADNIS , Arnaud Jean Francois Auguste CHEGUILLAUME , David Edward CLARK
IPC: C07D491/048 , A61P11/08
CPC classification number: C07D491/048 , A61P11/08
Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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公开(公告)号：US20210023080A1
公开(公告)日：2021-01-28
申请号：US16639486
申请日：2018-09-05
Applicant: Chiesi Farmaceutici S.p.A.
Inventor： Alessandro ACCETTA , Anna Maria CAPELLI , Fabio RANCATI , Gurdip BHALAY , Arnaud Jean Francois Auguste CHEGUILLAUME , Christine EDWARDS , Patrizia TISSELLI
IPC: A61K31/4995 , A61K9/00 , A61K31/496 , C07D471/04 , A61K31/437 , C07D487/08
Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are tyrosine analogues derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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公开(公告)号：US20200079774A1
公开(公告)日：2020-03-12
申请号：US16656842
申请日：2019-10-18
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Alessandro ACCETTA , Fabio RANCATI , Anna Maria CAPELLI , David Edward CLARK , Patrizia TISSELLI , Christine EDWARDS , Gurdip BHALAY , Arnaud Jean Francois Auquste CHEGUILLAUME
IPC: C07D471/04 , A61K9/00 , A61K31/437 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D471/08 , C07D498/04 , C07D519/00 , C07D487/04
Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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