公开(公告)号：US20090149635A1

公开(公告)日：2009-06-11

申请号：US12193665

申请日：2008-08-18

申请人： CINDY A. SPRECHER ,  JOSEPH L. KUIJPER ,  MARIA M. DASOVICH ,  FRANCIS J. GRANT ,  ANGELA K. HAMMOND ,  JANE A. GROSS

发明人： CINDY A. SPRECHER ,  JOSEPH L. KUIJPER ,  MARIA M. DASOVICH ,  FRANCIS J. GRANT ,  ANGELA K. HAMMOND ,  JANE A. GROSS

IPC分类号： C07K16/00

CPC分类号： C07K16/24 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/52 ,  C07K2317/24

摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 本发明涉及zcytor17lig多核苷酸，多肽和抗zcytor17抗体分子。 zcytor17lig是一种新型细胞因子。 多肽可用于刺激免疫系统的方法，体外和体内造血细胞的增殖和/或发育。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：US20100266597A1

公开(公告)日：2010-10-21

申请号：US12431623

申请日：2009-04-28

申请人： CINDY A. SPRECHER ,  ZEREN GAO ,  JOSEPH L. KUIJPER ,  MARIA M. DASOVICH ,  FRANCIS J. GRANT ,  SCOTT R. PRESNELL ,  THEODORE E. WHITMORE ,  ANGELA K. HAMMOND ,  JULIA E. NOVAK ,  JANE A. GROSS ,  STACEY R. DILLON

发明人： CINDY A. SPRECHER ,  ZEREN GAO ,  JOSEPH L. KUIJPER ,  MARIA M. DASOVICH ,  FRANCIS J. GRANT ,  SCOTT R. PRESNELL ,  THEODORE E. WHITMORE ,  ANGELA K. HAMMOND ,  JULIA E. NOVAK ,  JANE A. GROSS ,  STACEY R. DILLON

IPC分类号： A61K39/395 ,  C07K16/28 ,  C12N9/00 ,  A61P37/00 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.