公开(公告)号：US11866398B2

公开(公告)日：2024-01-09

申请号：US17055970

申请日：2019-05-14

Applicant: California Institute of Technology

Inventor： Jiaming Li ,  Xu Chen ,  Tonia S. Ahmed ,  Brian M. Stoltz ,  Robert H. Grubbs

IPC: C07C405/00 ,  B01J23/46

CPC classification number: C07C405/0016 ,  B01J23/462 ,  C07C2601/10

Abstract: This invention relates generally to the synthesis of Δ12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).

公开(公告)号：US10995049B2

公开(公告)日：2021-05-04

申请号：US16922290

申请日：2020-07-07

Applicant: California Institute of Technology

Inventor： Jiaming Li ,  Chen Xu ,  Tonia S Ahmed ,  Robert H Grubbs ,  Brian M. Stoltz

IPC: C07C45/29 ,  C07C29/00 ,  C07C49/557 ,  C07C49/577

Abstract: The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R1 is defined in the specification

公开(公告)号：US20210017111A1

公开(公告)日：2021-01-21

申请号：US16922290

申请日：2020-07-07

Applicant: California Institute of Technology

Inventor： Jiaming Li ,  Chen Xu ,  Tonia S. Ahmed ,  Robert H. Grubbs ,  Brian M. Stoltz

IPC: C07C45/29 ,  C07C49/577 ,  C07C49/557

Abstract: The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R1 is defined in the specification