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公开(公告)号：US11866398B2
公开(公告)日：2024-01-09
申请号：US17055970
申请日：2019-05-14
Applicant: California Institute of Technology
Inventor： Jiaming Li , Xu Chen , Tonia S. Ahmed , Brian M. Stoltz , Robert H. Grubbs
IPC: C07C405/00 , B01J23/46
CPC classification number: C07C405/0016 , B01J23/462 , C07C2601/10
Abstract: This invention relates generally to the synthesis of Δ12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).
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公开(公告)号：US11807617B2
公开(公告)日：2023-11-07
申请号：US17336756
申请日：2021-06-02
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Tonia S. Ahmed , Robert H. Grubbs
IPC: C07D313/00 , B01J31/22
CPC classification number: C07D313/00 , B01J31/226 , B01J31/2273 , B01J31/2291 , B01J2231/543 , B01J2531/821
Abstract: A highly efficient, Z-selective ring-closing metathesis system for the formation of macrocycles using a stereoretentive, ruthenium-based catalyst supported by a dithiolate ligand is reported. This catalyst is demonstrated to be remarkably active as observed in initiation experiments showing complete catalyst initiation at −20° C. within 10 min. Using easily accessible diene starting materials bearing a Z-olefin moiety, macrocyclization reactions generated products with significantly higher Z-selectivity in appreciably shorter reaction times, in higher yield, and with much lower catalyst loadings than in previously reported systems. Macrocyclic lactones ranging in size from twelve-membered to seventeen-membered rings are synthesized in moderate to high yields (68-79% yield) with excellent Z-selectivity (95%-99% Z).
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公开(公告)号：US20230346886A1
公开(公告)日：2023-11-02
申请号：US18076786
申请日：2022-12-07
Applicant: California Institute of Technology , The Regents of the University of California , U.S. Government represented by the Department of Veterans Affairs
Inventor： Robert H. Grubbs , Daniel M. Schwartz
CPC classification number: A61K38/1891 , A61B3/102 , A61B3/1241 , A61K9/0048 , A61K38/1866 , A61P27/02
Abstract: Disclosed herein include methods, kits, formulations, and compositions for increasing choroidal or retinal perfusion or promoting non-leaking or minimally-leaking choroidal or retinal revascularization in a subject in need thereof. An effective amount of an angiogenesis factor (e.g., a pro-angiogenic factor and/or a vascular maturation factor) can be administered to the subject.
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公开(公告)号：US20220088198A1
公开(公告)日：2022-03-24
申请号：US17544630
申请日：2021-12-07
Inventor： Robert H. Grubbs , Marshall L. Stoller , Hoyong Chung , Alissa M. Fitzgerald , Thomas W. Kenny , Renee M. Thomas
Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
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公开(公告)号：US11028107B2
公开(公告)日：2021-06-08
申请号：US15438929
申请日：2017-02-22
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Anton Toutov , Wenbo Liu , David P. Schuman , Brian M. Stoltz , Robert H. Grubbs
Abstract: The present invention is directed to compositions for silylating organic substrates containing C—H or O—H bonds, especially heteroaromatic substrates. The compositions are derived from the preconditioning of mixtures of hydrosilanes or organodisilanes with bases, including metal hydroxide and metal alkoxide bases. In some embodiments, the preconditioning results in the formation of reactive silicon hydride species.
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Patent Agency Ranking
公开(公告)号：US20200222311A1
公开(公告)日：2020-07-16
申请号：US16831781
申请日：2020-03-26
Applicant: California Institute of Technology
Inventor： Vanessa M. Marx , Robert H. Grubbs
IPC: A61K9/00 , C07F9/38 , A61K9/107 , A61K31/663 , A61K9/12 , A61N5/02 , A61N7/02 , C07B41/12 , C07B43/06
Abstract: The present disclosure is directed to fatty-acid glycerol ester derivative compounds containing a targeting bisphosphonate group. The disclosure further include pharmaceutical or biomedical compositions comprising these compounds, and methods of using these compounds and compositions forming microbubbles. The microbubbles have affinity for metal-containing, especially calcium-containing, bodies and/or biological targets. In certain embodiments, these compositions are useful for providing targeted placement of microbubbles capable of cavitation on application of high frequency energy
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公开(公告)号：US10406227B2
公开(公告)日：2019-09-10
申请号：US14650208
申请日：2013-12-18
Inventor： Robert H. Chow , Mark S. Humayun , Harry B. Gray , Robert H. Grubbs , Dennis A. Dougherty , Mark E. Thompson , Lionel E. Cheruzel , Melanie A. Yen
Abstract: Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.
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8.发明授权公开(公告)号：US10398805B2
公开(公告)日：2019-09-03
申请号：US15893798
申请日：2018-02-12
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Robert H. Grubbs , Shane L. Mangold
IPC: C08F2/46 , C08F2/50 , C08G61/04 , A61L27/50 , C08F222/38 , A61L27/04 , A61L27/14 , A61F2/16 , A61F9/00 , C08F2/48
Abstract: This disclosure relates compositions comprising upconverting nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable ocular lenses. Other methods improve the mechanical strength of the sclera directly.
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9.发明申请公开(公告)号：US20190241587A1
公开(公告)日：2019-08-08
申请号：US16384178
申请日：2019-04-15
Applicant: California Institute Of Technology
Inventor： Anton Toutov , Kerry Betz , Andrew M. Romine , Robert H. Grubbs
IPC: C07F7/18 , C07F7/08 , C07F7/21 , C07D235/08
CPC classification number: C07F7/1804 , C07D235/08 , C07F7/0896 , C07F7/21
Abstract: The present disclosure is directed to methods for dehydrogenatively coupled hydrosilanes and alcohols, the methods comprising contacting an organic substrate having at least one organic alcohol moiety with a mixture of at least one hydrosilane and sodium and/or potassium hydroxide, the contacting resulting in the formation of a dehydrogenatively coupled silyl ether. The disclosure further described associated compositions and methods of using the formed products.
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公开(公告)号：US10357565B2
公开(公告)日：2019-07-23
申请号：US16154677
申请日：2018-10-08
Inventor： Robert H. Grubbs , Marshall L. Stoller , Hoyong Chung , Alissa M. Fitzgerald , Thomas W. Kenny , Renee M. Thomas
Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
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