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公开(公告)号：US09624300B2
公开(公告)日：2017-04-18
申请号：US13716973
申请日：2012-12-17
发明人： Tibor Keler , Lizhen He , Venky Ramakrishna , Laura A. Vitale
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/21 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： Isolated monoclonal antibodies which bind to human DEC-205 and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
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公开(公告)号：US11332537B2
公开(公告)日：2022-05-17
申请号：US17405861
申请日：2021-08-18
发明人： Tibor Keler , Joel Goldstein , Laura A. Vitale , Lizhen He
摘要： Provided herein are anti-CD27 and anti-PD-L1 antibodies, and binding domains thereof, as well as bispecific constructs and anti-CD27 binding domain linked to an anti-PD-L1 binding domain. Also provided herein are methods of stimulating T cell activity, methods of inducing or enhancing an immune response, and methods of treating a disease or condition by administering the bispecific constructs, antibodies, or antigen binding fragments thereof, or compositions described herein to a patient in need thereof.
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公开(公告)号：US10941201B2
公开(公告)日：2021-03-09
申请号：US16986613
申请日：2020-08-06
发明人： Tibor Keler , Joel Goldstein , Laura A. Vitale , Lizhen He , Tom O'Neill , Andrea Crocker , Karuna Sundarapandiyan , Lawrence J. Thomas , Jenifer Widger
IPC分类号： A61K39/395 , C07K16/28 , C07K14/54 , C07K14/715 , C07K14/705 , A61K39/00
摘要： Isolated monoclonal agonistic antibodies which bind to human CD40 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
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公开(公告)号：US11459393B2
公开(公告)日：2022-10-04
申请号：US16387228
申请日：2019-04-17
发明人： Tibor Keler , Joel Goldstein , Laura A. Vitale , Lizhen He
摘要： Provided herein are anti-CD27 and anti-PD-L1 antibodies, and binding domains thereof, as well as bispecific constructs and anti-CD27 binding domain linked to an anti-PD-L1 binding domain. Also provided herein are methods of stimulating T cell activity, methods of inducing or enhancing an immune response, and methods of treating a disease or condition by administering the bispecific constructs, antibodies, or antigen binding fragments thereof, or compositions described herein to a patient in need thereof.
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公开(公告)号：US11180566B2
公开(公告)日：2021-11-23
申请号：US14790247
申请日：2015-07-02
发明人： Tibor Keler , Henry C. Marsh , Lizhen He , Laura A. Vitale , Lawrence J. Thomas
摘要： Isolated monoclonal antibodies which bind to human CD27 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
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