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公开(公告)号：US11965031B2
公开(公告)日：2024-04-23
申请号：US17099547
申请日：2020-11-16
发明人： Vladimir Coric , Tibor Keler , Thomas Davis
CPC分类号： C07K16/2878 , A61K39/00 , A61K39/0008 , A61K39/0011 , A61K39/001129 , A61K39/00115 , A61K39/39558 , A61K45/06 , A61P35/00 , C07K16/2818 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K16/3069 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K2317/21 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.
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公开(公告)号：US10392442B2
公开(公告)日：2019-08-27
申请号：US15384205
申请日：2016-12-19
发明人： Vladimir Coric , Tibor Keler , Thomas Davis
IPC分类号： A61K39/395 , C07K16/28 , A61K45/06 , A61K39/00 , A61P35/00
摘要： This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.
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公开(公告)号：US20170174774A1
公开(公告)日：2017-06-22
申请号：US15384205
申请日：2016-12-19
发明人： Vladimir CORIC , Tibor Keler , Thomas Davis
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395 , C07K16/30
CPC分类号： C07K16/2878 , A61K39/00 , A61K39/0008 , A61K39/0011 , A61K39/001129 , A61K39/00115 , A61K39/39558 , A61K45/06 , A61K2039/507 , A61K2039/545 , A61P35/00 , C07K16/2818 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.
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公开(公告)号：US11332537B2
公开(公告)日：2022-05-17
申请号：US17405861
申请日：2021-08-18
发明人： Tibor Keler , Joel Goldstein , Laura A. Vitale , Lizhen He
摘要： Provided herein are anti-CD27 and anti-PD-L1 antibodies, and binding domains thereof, as well as bispecific constructs and anti-CD27 binding domain linked to an anti-PD-L1 binding domain. Also provided herein are methods of stimulating T cell activity, methods of inducing or enhancing an immune response, and methods of treating a disease or condition by administering the bispecific constructs, antibodies, or antigen binding fragments thereof, or compositions described herein to a patient in need thereof.
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公开(公告)号：US10941201B2
公开(公告)日：2021-03-09
申请号：US16986613
申请日：2020-08-06
发明人： Tibor Keler , Joel Goldstein , Laura A. Vitale , Lizhen He , Tom O'Neill , Andrea Crocker , Karuna Sundarapandiyan , Lawrence J. Thomas , Jenifer Widger
IPC分类号： A61K39/395 , C07K16/28 , C07K14/54 , C07K14/715 , C07K14/705 , A61K39/00
摘要： Isolated monoclonal agonistic antibodies which bind to human CD40 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
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公开(公告)号：US10668152B2
公开(公告)日：2020-06-02
申请号：US15613192
申请日：2017-06-03
发明人： Vladimir Coric , Tibor Keler , Thomas Davis
摘要： This disclosure provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.
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公开(公告)号：US11541076B2
公开(公告)日：2023-01-03
申请号：US16477609
申请日：2018-01-12
发明人： Terrance A. Stadheim , Joana M. Murad , Jake Reder , Henry C. Marsh, Jr. , Li-Zhen He , Tibor Keler
IPC分类号： C07K16/28 , A61K35/17 , A61P35/00 , C07K14/725 , C07K14/705 , C07K16/30 , C12N15/85
摘要： The invention provides chimeric antigen receptors (CARs) that specifically bind to the T-cell immunoglobulin and mucin domain 1 (TIM-1) protein. The invention further relates to modified immune cells, e.g., T or NK cells, comprising such CARs, CAR-encoding nucleic acids, CAR-encoding vectors, and methods of making such compositions. The invention further relates to methods for therapeutic use of these CARs and modified immune cells for the treatment of a condition, disorder, or disease associated with cells expressing TIM-1 (e.g., cancer).
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公开(公告)号：US09624300B2
公开(公告)日：2017-04-18
申请号：US13716973
申请日：2012-12-17
发明人： Tibor Keler , Lizhen He , Venky Ramakrishna , Laura A. Vitale
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/21 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： Isolated monoclonal antibodies which bind to human DEC-205 and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
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公开(公告)号：US20160355593A1
公开(公告)日：2016-12-08
申请号：US14993265
申请日：2016-01-12
发明人： Tibor Keler , Michael Endres , Lizhen He , Venky Ramakrishna
CPC分类号： C07K16/2851 , A61K39/0006 , A61K39/0011 , A61K2039/5154 , A61K2039/572 , A61K2039/6056 , C07K14/59 , C07K16/28 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C07K2318/10 , C07K2319/00 , C07K2319/33 , Y02A50/401 , Y02A50/412 , Y02A50/469
摘要： The present invention provides novel antibody vaccine conjugates and methods of using the same to induce a cytotoxic T cell (CTL) response. In a particular, embodiment, the vaccine conjugate includes a human chorionic gonadotropin beta subunit (βhCG) antigen linked to an anti-mannose receptor (MR) antibody.
摘要翻译： 本发明提供新的抗体疫苗缀合物及其使用方法诱导细胞毒性T细胞（CTL）应答。 在具体的实施方案中，疫苗缀合物包括与抗甘露糖受体（MR）抗体连接的人绒毛膜促性腺激素β亚基（βhCG）抗原。
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公开(公告)号：US11459393B2
公开(公告)日：2022-10-04
申请号：US16387228
申请日：2019-04-17
发明人： Tibor Keler , Joel Goldstein , Laura A. Vitale , Lizhen He
摘要： Provided herein are anti-CD27 and anti-PD-L1 antibodies, and binding domains thereof, as well as bispecific constructs and anti-CD27 binding domain linked to an anti-PD-L1 binding domain. Also provided herein are methods of stimulating T cell activity, methods of inducing or enhancing an immune response, and methods of treating a disease or condition by administering the bispecific constructs, antibodies, or antigen binding fragments thereof, or compositions described herein to a patient in need thereof.
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