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    REAL-TIME COLORIMETRIC SCREENING INHIBITORS OF ENDONUCLEASE WITH GOLD NANOPARTICLE SUBSTRATE
    6.
    发明申请
    REAL-TIME COLORIMETRIC SCREENING INHIBITORS OF ENDONUCLEASE WITH GOLD NANOPARTICLE SUBSTRATE 审中-公开
    具有金纳米晶基质的内切酶的实时彩色荧光筛选抑制剂

    公开(公告)号：US20090155785A1

    公开(公告)日：2009-06-18

    申请号：US12020506

    申请日：2008-01-25

    申请人： Chad A. Mirkin ,  Xiaoyang Xu ,  Min Su Han

    发明人： Chad A. Mirkin ,  Xiaoyang Xu ,  Min Su Han

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/553 ,  B82Y5/00 ,  C12Q1/34 ,  G01N33/587

    摘要： The invention provides methods for screening a compound for its effect on endonuclease activity. The methods comprise providing a compound to be screened utilizing a gold nanoparticle aggregate as the substrate for the endonuclease. The gold nanoparticle aggregate is formed by the hybridization of oligonucleotides attached to the nanoparticles, with or without the presence of a third linker oligonucleotide. The hybridized oligonucleotide duplex serves as a substrate for the endonuclease. A detectable change is brought about in the presence of the endonuclease activity. A decrease in the detectable change reflects the reduced levels of endonuclease activities as a result of the effects of endonuclease inhibitors. The present invention also provides kits for screening an endonuclease inhibitor.

    摘要翻译： 本发明提供了筛选化合物对其对核酸内切酶活性的影响的方法。 所述方法包括使用金纳米颗粒聚集体作为内切核酸酶的底物提供待筛选的化合物。 金纳米颗粒聚集体通过与或不与第三接头寡核苷酸的存在连接到纳米颗粒上的寡核苷酸的杂交形成。 杂交的寡核苷酸双链体用作内切核酸酶的底物。 在存在核酸内切酶活性的情况下可以发现可检测的变化。 可检测变化的降低反映了由于内切核酸酶抑制剂的作用而导致的内切核酸酶活性的降低。 本发明还提供了用于筛选内切核酸酶抑制剂的试剂盒。

    Combined positioning device for side beam of stainless steel car roof
    7.
    发明授权
    Combined positioning device for side beam of stainless steel car roof 有权
    不锈钢车顶侧梁组合定位装置

    公开(公告)号：US09073181B2

    公开(公告)日：2015-07-07

    申请号：US13699036

    申请日：2011-07-12

    申请人： Xiaoyang Xu

    发明人： Xiaoyang Xu

    IPC分类号： B25B1/00 ,  B25B1/20 ,  B25B1/02 ,  B25B5/14 ,  B23K37/04 ,  B25B5/00

    CPC分类号： B25B5/14 ,  B23K37/0443 ,  B25B5/006

    摘要： The utility model provides a combined positioning device for a side beam of a stainless steel car roof, comprising an inner cavity positioning block (2), an external support body (3), an external positioning block (4), a push rod (5), and clamps (6), a top side of the inner cavity positioning block (2) fits in with a top inner portion of the side beam (7) of the car roof, the external support body (3) is adjustably connected to a surface of the inner cavity positioning block (2), the external positioning block (4) is adjustably connected to a surface of the external support body (3), an elongated nut of the push rod (5) is integrated with the inner cavity positioning block (2), and the clamps (6) are used to clamp two edges of the side beam (7) of the car roof. With the present utility model, the side beam of the car roof can be supported by fitting the inner cavity positioning block in with the top inner portion of the side beam of the car roof, and sizes such as width and height can be adjusted through adjustments of the external support body connected to the inner cavity positioning block, the external positioning block and the clamps.

    摘要翻译： 本实用新型提供了一种用于不锈钢车顶的侧梁的组合定位装置，包括内腔定位块（2），外支撑体（3），外定位块（4），推杆（5） ）和夹具（6），内腔定位块（2）的顶侧与轿厢顶板的侧梁（7）的顶部内部部分配合，外部支撑体（3）可调节地连接到 所述内腔定位块（2）的表面，所述外定位块（4）可调节地连接到所述外支撑体（3）的表面，所述推杆（5）的细长螺母与所述内腔 定位块（2）和夹具（6）用于夹紧车顶的侧梁（7）的两个边缘。 利用本实用新型，车顶的侧梁可以通过将内腔定位块与轿厢顶梁的侧梁的顶部内部部分配合来支撑，并且可以通过调节来调节诸如宽度和高度的尺寸 外部支撑体连接到内腔定位块，外部定位块和夹具。

    COMBINED POSITIONING DEVICE FOR SIDE BEAM OF STAINLESS STEEL CAR ROOF
    8.
    发明申请
    COMBINED POSITIONING DEVICE FOR SIDE BEAM OF STAINLESS STEEL CAR ROOF 有权
    用于不锈钢车厢侧梁的组合定位装置

    公开(公告)号：US20130134643A1

    公开(公告)日：2013-05-30

    申请号：US13699036

    申请日：2011-07-12

    申请人： Xiaoyang Xu

    发明人： Xiaoyang Xu

    IPC分类号： B25B5/14

    CPC分类号： B25B5/14 ,  B23K37/0443 ,  B25B5/006

    摘要： The utility model provides a combined positioning device for a side beam of a stainless steel car roof, comprising an inner cavity positioning block (2), an external support body (3), an external positioning block (4), a push rod (5), and clamps (6), a top side of the inner cavity positioning block (2) fits in with a top inner portion of the side beam (7) of the car roof, the external support body (3) is adjustably connected to a surface of the inner cavity positioning block (2), the external positioning block (4) is adjustably connected to a surface of the external support body (3), an elongated nut of the push rod (5) is integrated with the inner cavity positioning block (2), and the clamps (6) are used to clamp two edges of the side beam (7) of the car roof. With the present utility model, the side beam of the car roof can be supported by fitting the inner cavity positioning block in with the top inner portion of the side beam of the car roof, and sizes such as width and height can be adjusted through adjustments of the external support body connected to the inner cavity positioning is block, the external positioning block and the clamps.

    摘要翻译： 本实用新型提供了一种用于不锈钢车顶的侧梁的组合定位装置，包括内腔定位块（2），外支撑体（3），外定位块（4），推杆（5） ）和夹具（6），内腔定位块（2）的顶侧与轿厢顶板的侧梁（7）的顶部内部部分配合，外部支撑体（3）可调节地连接到 所述内腔定位块（2）的表面，所述外定位块（4）可调节地连接到所述外支撑体（3）的表面，所述推杆（5）的细长螺母与所述内腔 定位块（2）和夹具（6）用于夹紧车顶的侧梁（7）的两个边缘。 利用本实用新型，车顶的侧梁可以通过将内腔定位块与轿厢顶梁的侧梁的顶部内部部分配合来支撑，并且可以通过调节来调整诸如宽度和高度的尺寸 外部支撑体连接到内腔的定位是块体，外部定位块和夹具。

    Apparatus for correcting upward deformation of large member of stainless steel car roof
    9.
    发明授权
    Apparatus for correcting upward deformation of large member of stainless steel car roof 有权

    公开(公告)号：US09636730B2

    公开(公告)日：2017-05-02

    申请号：US13701101

    申请日：2011-07-12

    申请人： Xiaoyang Xu ,  Ting Wang

    发明人： Xiaoyang Xu ,  Ting Wang

    IPC分类号： B21D1/12 ,  B21D1/14

    CPC分类号： B21D1/12 ,  B21D1/14

    摘要： The utility model provides an apparatus for correcting upwarp deformation of a large member of a stainless steel car roof, being characterized in that, it has a crossbeam, end support columns, a middle support column, an arc-shaped positioning body, crossbeam pull rings, a thin steel taut strap, and tighteners. The end support columns, crossbeam, and middle support column constitute a supporting part, the arc-shaped positioning body having the same arc shape as an inner arc of the large member of the stainless steel car roof is arranged on the middle support column. The thin steel taut strap covers an exterior contour surface of the large member of the stainless steel car roof, and is connected via the tightener to the crossbeam pull rings respectively fixed at two ends of the crossbeam.

    Safety protection device for roof construction of train body assembly
    10.
    发明授权
    Safety protection device for roof construction of train body assembly 有权
    火车车身总成屋顶施工安全保护装置

    公开(公告)号：US08544602B2

    公开(公告)日：2013-10-01

    申请号：US13310411

    申请日：2011-12-02

    申请人： Xiaoyang Xu ,  Xiuqin Gao

    发明人： Xiaoyang Xu ,  Xiuqin Gao

    IPC分类号： A62B35/00 ,  B66F11/00

    CPC分类号： B61K13/00 ,  A62B35/0056

    摘要： A safety protection device for the roof construction of a train body assembly comprises two arch bridge shaped transverse walking boards and a safety rope, wherein the safety rope is fixed between the span of the two arch bridge shaped transverse walking boards. The invention has the following benefit effects: the safety for the worker walking and working on the roof can be guaranteed since the worker walks up to the roof through the arch bridge shaped transverse walking boards and ties the other end of a safety belt which is tied on him to the safety rope.

    摘要翻译： 一种用于火车车身组件屋顶结构的安全保护装置，包括两个拱形桥形横向步行板和一根安全绳，其中安全绳固定在两个拱桥横向行走板的跨距之间。 本发明具有以下效果：工人在屋顶上行走和工作的安全性可以得到保证，因为工人通过拱形桥形横向步行板走向屋顶，并将绑扎的安全带的另一端 对他安全绳。