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公开(公告)号：US20240150782A1
公开(公告)日：2024-05-09
申请号：US18409603
申请日：2024-01-10
申请人： Commonwealth Scientific and Industrial Research Organisation , GRAINS RESEARCH AND DEVELOPMENT CORPORATION
发明人： James Robertson Petrie , Anne Maree Mackenzie , Qing Liu , Pushkar Shrestha , Peter David Nichols , Susan Irene Ellis Blackburn , Maged Peter Mansour , Stanley Suresh Robert , Dion Matthew Frederick Frampton , Xue-Rong Zhou , Surinder Pal Singh , Craig Christopher Wood
IPC分类号： C12N15/82 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472
CPC分类号： C12N15/8247 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472 , C12Y602/01003
摘要： The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ω3 desaturases, Δ5 elongases and Δ6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.
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公开(公告)号：US09976107B2
公开(公告)日：2018-05-22
申请号：US15661673
申请日：2017-07-27
申请人： Commonwealth Scientific and Industrial Research Organisation , Grains Research and Development Corporation
发明人： James Robertson Petrie , Anne Maree Mackenzie , Qing Liu , Pushkar Shrestha , Peter David Nichols , Susan Irene Ellis Blackburn , Maged Peter Mansour , Stanley Suresh Robert , Dion Matthew Frederick Frampton , Xue-Rong Zhou , Surinder Pal Singh , Craig Christopher Wood
CPC分类号： C11B3/006 , C12N9/0071 , C12N9/0083 , C12N9/1029 , C12N9/93 , C12N15/52 , C12N15/8202 , C12N15/8205 , C12N15/8216 , C12N15/8218 , C12N15/8234 , C12N15/8247 , C12N15/8257 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12Y114/00 , C12Y114/19 , C12Y114/19003 , C12Y602/01003
摘要： The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ω3 destaurases, Δ5 elongases and Δ6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.
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公开(公告)号：US20240150779A1
公开(公告)日：2024-05-09
申请号：US18409591
申请日：2024-01-10
申请人： Commonwealth Scientific and Industrial Research Organisation , GRAINS RESEARCH AND DEVELOPMENT CORPORATION
发明人： James Robertson Petrie , Anne Maree Mackenzie , Qing Liu , Pushkar Shrestha , Peter David Nichols , Susan Irene Ellis Blackburn , Maged Peter Mansour , Stanley Suresh Robert , Dion Matthew Frederick Frampton , Xue-Rong Zhou , Surinder Pal Singh , Craig Christopher Wood
IPC分类号： C12N15/82 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472
CPC分类号： C12N15/8247 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472 , C12Y602/01003
摘要： The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ω3 destaurases, Δ5 elongases and Δ6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.
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公开(公告)号：US10648046B2
公开(公告)日：2020-05-12
申请号：US15642223
申请日：2017-07-05
申请人： Commonwealth Scientific and Industrial Research Organisation , Grains Research and Development Corporation
发明人： James Robertson Petrie , Anne Maree Mackenzie , Qing Liu , Pushkar Shrestha , Peter David Nichols , Susan Irene Ellis Blackburn , Maged Peter Mansour , Stanley Suresh Robert , Dion Matthew Frederick Frampton , Xue-Rong Zhou , Surinder Pal Singh , Craig Christopher Wood
IPC分类号： C12N15/82
摘要： The present invention relates generally to the field of recombinant fatty acid synthesis, particularly in transgenic plants. The application describes genes involved in fatty acid synthesis and provides methods and vectors for the manipulation of fatty acid composition of plant oils. In particular, the invention provides constructs for achieving the integration of multiple heterologous genes involved in fatty acid synthesis into the plant genome, such that the resulting plants produce altered levels of polyunsaturated fatty acids. Also described are methods for enhancing the expression of fatty acid biosynthesis enzymes by co-expressing a silencing suppressor within the plant storage organ.
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公开(公告)号：US20240150781A1
公开(公告)日：2024-05-09
申请号：US18409598
申请日：2024-01-10
申请人： Commonwealth Scientific and Industrial Research Organisation , GRAINS RESEARCH AND DEVELOPMENT CORPORATION
发明人： James Robertson Petrie , Anne Maree Mackenzie , Qing Liu , Pushkar Shrestha , Peter David Nichols , Susan Irene Ellis Blackburn , Maged Peter Mansour , Stanley Suresh Robert , Dion Matthew Frederick Frampton , Xue-Rong Zhou , Surinder Pal Singh , Craig Christopher Wood
IPC分类号： C12N15/82 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472
CPC分类号： C12N15/8247 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472 , C12Y602/01003
摘要： The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ω3 destaurases, Δ5 elongases and Δ6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.
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公开(公告)号：US20240360464A1
公开(公告)日：2024-10-31
申请号：US18656570
申请日：2024-05-06
申请人： Commonwealth Scientific and Industrial Research Organisation , GRAINS RESEARCH AND DEVELOPMENT CORPORATION
发明人： James Robertson Petrie , Anne Maree Mackenzie , Qing Liu , Pushkar Shrestha , Peter David Nichols , Susan Irene Ellis Blackburn , Maged Peter Mansour , Stanley Suresh Robert , Dion Matthew Frederick Frampton , Xue-Rong Zhou , Surinder Pal Singh , Craig Christopher Wood
IPC分类号： C12N15/82 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472
CPC分类号： C12N15/8247 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472 , C12Y602/01003
摘要： The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides Ω3 destaurases, Δ5 elongases and Δ6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.
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公开(公告)号：US20240150780A1
公开(公告)日：2024-05-09
申请号：US18409596
申请日：2024-01-10
申请人： Commonwealth Scientific and Industrial Research Organisation , GRAINS RESEARCH AND DEVELOPMENT CORPORATION
发明人： James Robertson Petrie , Anne Maree Mackenzie , Qing Liu , Pushkar Shrestha , Peter David Nichols , Susan Irene Ellis Blackburn , Maged Peter Mansour , Stanley Suresh Robert , Dion Matthew Frederick Frampton , Xue-Rong Zhou , Surinder Pal Singh , Craig Christopher Wood
IPC分类号： C12N15/82 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472
CPC分类号： C12N15/8247 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472 , C12Y602/01003
摘要： The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ω3 destaurases, Δ5 elongases and Δ6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.
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公开(公告)号：US11976287B2
公开(公告)日：2024-05-07
申请号：US16860936
申请日：2020-04-28
申请人： Commonwealth Scientific and Industrial Research Organisation , GRAINS RESEARCH AND DEVELOPMENT CORPORATION
发明人： James Robertson Petrie , Anne Maree Mackenzie , Qing Liu , Pushkar Shrestha , Peter David Nichols , Susan Irene Ellis Blackburn , Maged Peter Mansour , Stanley Suresh Robert , Dion Matthew Frederick Frampton , Xue-Rong Zhou , Surinder Pal Singh , Craig Christopher Wood
IPC分类号： C12N15/82 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472
CPC分类号： C12N15/8247 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472 , C12Y602/01003
摘要： The present invention relates generally to the field of recombinant fatty acid synthesis, particularly in transgenic plants. The application describes genes involved in fatty acid synthesis and provides methods and vectors for the manipulation of fatty acid composition of plant oils. In particular, the invention provides constructs for achieving the integration of multiple heterologous genes involved in fatty acid synthesis into the plant genome, such that the resulting plants produce altered levels of polyunsaturated fatty acids. Also described are methods for enhancing the expression of fatty acid biosynthesis enzymes by co-expressing a silencing suppressor within the plant storage organ.
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公开(公告)号：US09994792B2
公开(公告)日：2018-06-12
申请号：US15644635
申请日：2017-07-07
申请人： Commonwealth Scientific and Industrial Research Organisation , Grains Research and Development Corporation
发明人： James Robertson Petrie , Anne Maree Mackenzie , Qing Liu , Pushkar Shrestha , Peter David Nichols , Susan Irene Ellis Blackburn , Maged Peter Mansour , Stanley Suresh Robert , Dion Matthew Frederick Frampton , Xue-Rong Zhou , Surinder Pal Singh , Craig Christopher Wood
CPC分类号： C11B3/006 , C12N9/0071 , C12N9/0083 , C12N9/1029 , C12N9/93 , C12N15/52 , C12N15/8202 , C12N15/8205 , C12N15/8216 , C12N15/8218 , C12N15/8234 , C12N15/8247 , C12N15/8257 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12Y114/00 , C12Y114/19 , C12Y114/19003 , C12Y602/01003
摘要： The present invention relates generally to the field of recombinant fatty acid synthesis, particularly in transgenic plants. The application describes genes involved in fatty acid synthesis and provides methods and vectors for the manipulation of fatty acid composition of plant oils. In particular, the invention provides constructs for achieving the integration of multiple heterologous genes involved in fatty acid synthesis into the plant genome, such that the resulting plants produce altered levels of polyunsaturated fatty acids. Also described are methods for enhancing the expression of fatty acid biosynthesis enzymes by co-expressing a silencing suppressor within the plant storage organ.
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公开(公告)号：US09938486B2
公开(公告)日：2018-04-10
申请号：US14332202
申请日：2014-07-15
申请人： Commonwealth Scientific and Industrial Research Organisation , Grains Research and Development Corporation
发明人： James Robertson Petrie , Anne Maree Mackenzie , Qing Liu , Pushkar Shrestha , Peter David Nichols , Susan Irene Ellis Blackburn , Maged Peter Mansour , Stanley Suresh Robert , Dion Matthew Frederick Frampton , Xue-Rong Zhou , Surinder Pal Singh , Craig Christopher Wood
CPC分类号： C11B3/006 , C12N9/0071 , C12N9/0083 , C12N9/1029 , C12N9/93 , C12N15/52 , C12N15/8202 , C12N15/8205 , C12N15/8216 , C12N15/8218 , C12N15/8234 , C12N15/8247 , C12N15/8257 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12Y114/00 , C12Y114/19 , C12Y114/19003 , C12Y602/01003
摘要： The present invention relates generally to the field of recombinant fatty acid synthesis, particularly in transgenic plants. The application describes genes involved in fatty acid synthesis and provides methods and vectors for the manipulation of fatty acid composition of plant oils. In particular, the invention provides constructs for achieving the integration of multiple heterologous genes involved in fatty acid synthesis into the plant genome, such that the resulting plants produce altered levels of polyunsaturated fatty acids. Also described are methods for enhancing the expression of fatty acid biosynthesis enzymes by co-expressing a silencing suppressor within the plant storage organ.
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