公开(公告)号：US10203320B2

公开(公告)日：2019-02-12

申请号：US14437275

申请日：2013-11-15

Applicant: Corning Incorporated

Inventor： Oberon Denaci Deichmann ,  Ye Fang ,  Ann MeeJin Ferrie ,  David Henry ,  Haibei Hu ,  Corinne Walerack ,  Qi Wu

IPC: G01N33/50 ,  G01N15/14 ,  G01N21/31 ,  G01N21/77 ,  G01N15/00

Abstract: A label-free resonant waveguide grating biosensor imager system for measuring beat patterns and dynamic mass redistribution (DMR) signals of cultured cardiomyocytes in the absence and presence of a drug molecule. The disclosure also provides a method using the imager system for analyzing the beat patterns and the DMR signals of the cardiomyocytes to assess drug-induced cardiotoxicity.

公开(公告)号：US20150268222A1

公开(公告)日：2015-09-24

申请号：US14437275

申请日：2013-11-15

Applicant: CORNING INCORPORATED

Inventor： Oberon Denaci Deichmann ,  Ye Fang ,  Ann MeeJin Ferrie ,  Haibei Hu ,  Qi Wu

IPC: G01N33/50 ,  G01N15/14 ,  G01N21/31

CPC classification number: G01N33/5014 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/3151 ,  G01N21/7743 ,  G01N33/502 ,  G01N33/5061 ,  G01N2015/0065 ,  G01N2015/144 ,  G01N2015/1454

Abstract: A label-free resonant waveguide grating biosensor imager system for measuring beat patterns and dynamic mass redistribution (DMR) signals of cultured cardiomyocytes in the absence and presence of a drug molecule. The disclosure also provides a method using the imager system for analyzing the beat patterns and the DMR signals of the cardiomyocytes to assess drug-induced cardiotoxicity.

Abstract translation: 一种无标记的谐振波导光栅生物传感器成像系统，用于在不存在和存在药物分子的情况下测量培养的心肌细胞的搏动模式和动态质量再分配（DMR）信号。 本公开还提供了一种使用成像仪系统分析心肌细胞的搏动模式和DMR信号以评估药物诱导的心脏毒性的方法。