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    Woven cell culture substrates, bioreactor systems using the same, and related methods
    4.
    发明授权
    Woven cell culture substrates, bioreactor systems using the same, and related methods 有权

    公开(公告)号：US11434460B2

    公开(公告)日：2022-09-06

    申请号：US16781685

    申请日：2020-02-04

    Applicant: CORNING INCORPORATED

    Inventor： Ann MeeJin Ferrie ,  Vasiliy Nikolaevich Goral ,  Lori E Romeo

    IPC: C12M1/12 ,  C12M1/00 ,  C12M1/34 ,  C12N5/00 ,  C12M3/00 ,  C12N5/071

    Abstract: A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.

    Fixed bed bioreactor and methods of using the same
    5.
    发明授权
    Fixed bed bioreactor and methods of using the same 有权

    公开(公告)号：US11118151B2

    公开(公告)日：2021-09-14

    申请号：US17039035

    申请日：2020-09-30

    Applicant: CORNING INCORPORATED

    Inventor： Ann MeeJin Ferrie ,  Vasiliy Nikolaevich Goral

    IPC: C12M1/12 ,  C12M1/00 ,  C12M3/00

    Abstract: A fixed-bed bioreactor system is provided that includes a vessel with a media inlet, a media outlet, and an interior cavity disposed between and in fluid communication with the media inlet and media outlet. The vessel further includes a cell culture substrate disposed in the interior cavity between the media inlet and the media outlet in a packed-bed configuration, the cell culture substrate including a plurality of porous disks in a stacked arrangement. The interior cavity includes a cell culture section and a spacer section, the cell culture substrate defining the cell culture section and the spacer section being disposed between the cell culture section and the media outlet, and each of the plurality of porous disks has a surface configured to culture cells thereon.

    PACKED-BED BIOREACTOR SYSTEMS AND METHODS OF USING THE SAME
    6.
    发明申请
    PACKED-BED BIOREACTOR SYSTEMS AND METHODS OF USING THE SAME 审中-公开

    公开(公告)号：US20200248123A1

    公开(公告)日：2020-08-06

    申请号：US16781847

    申请日：2020-02-04

    Applicant: CORNING INCORPORATED

    Inventor： Ann MeeJin Ferrie ,  Vasiliy Nikolaevich Goral ,  Lori E. Romeo

    IPC: C12M1/12 ,  C12M1/00 ,  C12N5/00

    Abstract: A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.

    FIXED BED BIOREACTOR AND METHODS OF USING THE SAME
    9.
    发明申请
    FIXED BED BIOREACTOR AND METHODS OF USING THE SAME 有权

    公开(公告)号：US20250027018A1

    公开(公告)日：2025-01-23

    申请号：US18905675

    申请日：2024-10-03

    Applicant: CORNING INCORPORATED

    Inventor： Ann MeeJin Ferrie ,  Vasiliy Nikolaevich Goral

    IPC: C12M1/12 ,  C12M1/00 ,  C12M3/00

    Abstract: A fixed-bed bioreactor system is provided that includes a vessel with a media inlet, a media outlet, and an interior cavity disposed between and in fluid communication with the media inlet and media outlet. The vessel further includes a cell culture substrate disposed in the interior cavity between the media inlet and the media outlet in a packed-bed configuration, the cell culture substrate including a plurality of porous disks in a stacked arrangement. The interior cavity includes a cell culture section and a spacer section, the cell culture substrate defining the cell culture section and the spacer section being disposed between the cell culture section and the media outlet, and each of the plurality of porous disks has a surface configured to culture cells thereon.

    Packed-bed bioreactor systems and methods of using the same
    10.
    发明授权
    Packed-bed bioreactor systems and methods of using the same 有权

    公开(公告)号：US12180451B2

    公开(公告)日：2024-12-31

    申请号：US18130668

    申请日：2023-04-04

    Applicant: CORNING INCORPORATED

    Inventor： Ann MeeJin Ferrie ,  Vasiliy Nikolaevich Goral

    IPC: C12M1/12 ,  C12M1/00 ,  C12M1/34 ,  C12M3/00 ,  C12N5/00 ,  C12N5/071

    Abstract: A bioreactor system is provided that includes a cell culture vessel having a first end, a second end, and at least one reservoir between the first and second ends; and a cell culture matrix disposed in the at least one reservoir. The cell culture matrix has a structurally defined substrate with a surface for adhering cells thereto. The bioreactor system flows material through the at least one reservoir and through the cell culture matrix in a flow direction from the first end to the second end, and the cell culture matrix exhibits isotropic fluid flow permeability therethrough.

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