公开(公告)号：US20220034748A1

公开(公告)日：2022-02-03

申请号：US17276981

申请日：2019-09-09

Applicant: Cytiva Sweden AB

Inventor： Sameera Simha Hindupur ,  Manoj Kumar Ramakrishna ,  Andreas Castan ,  Swapnil Puranik ,  Klaus Gebauer

IPC: G01M3/28 ,  B29C65/82 ,  B29C65/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34

Abstract: The present invention relates to a computer implemented method for determining a weld integrity test result performed by a system configured to aseptically transferring cells to a container (BR), the method comprising welding (710) a vial to a connector to obtain a fluid-tight seal between the vial (V) and a connector (C), the connector being provided with a pair of conduits each having one end protruding through the connector and into the vial, sealing (720) an opposite end of one of the conduits, generating (730) a fluid pressure different to an ambient fluid pressure at an opposite end of the other conduit, measuring (740) a fluid pressure within at least one of the conduits, determining (750) a fluid pressure change based on the ambient pressure and the measured fluid pressure, determining (760) the weld integrity test result as pass or as fail based on the fluid pressure change.

公开(公告)号：US11927503B2

公开(公告)日：2024-03-12

申请号：US17276981

申请日：2019-09-09

Applicant: Cytiva Sweden AB

Inventor： Sameera Simha Hindupur ,  Manoj Kumar Ramakrishna ,  Andreas Castan ,  Swapnil Puranik ,  Klaus Gebauer

IPC: G01M3/28 ,  B29C65/00 ,  B29C65/82 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34

CPC classification number: G01M3/2884 ,  B29C65/8246 ,  B29C66/522 ,  C12M23/40 ,  C12M37/04 ,  C12M41/40

Abstract: The present invention relates to a computer implemented method for determining a weld integrity test result performed by a system configured to aseptically transferring cells to a container (BR), the method comprising welding (710) a vial to a connector to obtain a fluid-tight seal between the vial (V) and a connector (C), the connector being provided with a pair of conduits each having one end protruding through the connector and into the vial, sealing (720) an opposite end of one of the conduits, generating (730) a fluid pressure different to an ambient fluid pressure at an opposite end of the other conduit, measuring (740) a fluid pressure within at least one of the conduits, determining (750) a fluid pressure change based on the ambient pressure and the measured fluid pressure, determining (760) the weld integrity test result as pass or as fail based on the fluid pressure change.

公开(公告)号：US20210313033A1

公开(公告)日：2021-10-07

申请号：US17265780

申请日：2019-09-30

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer ,  Hanish Lakhani ,  Swapnil Puranik ,  Nishu Garg ,  Hemalatha J

IPC: G16H20/10 ,  G05B13/02 ,  G16H70/40

Abstract: A monitoring system comprises a manufacture system with capability to manufacture a plurality of biopharmaceutical products, at least one image capture device arranged to capture a scene comprising the manufacture system, and a processing element connected to said at least one image capture device and arranged to process images captured by said at least one image capture device to track operator interactions and/or a result of operator interactions within the scene. The processing element is further is arranged to compare a predefined workflow process scheme relating to the selected biopharmaceutical product to at least a part of the tracked operator interactions with the manufacture system and/or to at least a part of the result of the tracked operator interactions with the manufacture system, and determine whether at least one pre-set criterion set by the workflow process scheme is fulfilled based on the comparison.