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公开(公告)号：US20180290998A1
公开(公告)日：2018-10-11
申请号：US15945334
申请日：2018-04-04
Applicant: DOW AGROSCIENCES LLC
Inventor： Michael R. Loso , Gary D. Gustafson , Asako Kubota , Maurice C. Yap , Zachary A. Buchan , Kimberly M. Steward , Michael T. Sullenberger , William J. Hoekstra , Christopher M. Yates
IPC: C07D401/10 , A61K45/06 , A01N53/00 , C07D213/57 , C07D213/32 , A61K31/4406 , C07D213/30 , A01N47/02 , A61K31/506 , A61K31/505 , C07D239/26 , A01N43/54 , C07D239/34
Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US09957252B2
公开(公告)日：2018-05-01
申请号：US15586657
申请日：2017-05-04
Applicant: Dow AgroSciences LLC
Inventor： Michael R. Loso , Gary D. Gustafson , Asako Kubota , Maurice C. Yap , Zachary A. Buchan , Kimberly M. Steward , Michael T. Sullenberger , William J. Hoekstra , Christopher M. Yates
IPC: C07D401/10 , C07D239/26 , C07D213/30 , C07D213/32 , C07D213/57 , C07D239/34 , A61K31/505 , A01N47/02 , A01N43/54 , A61K31/4406 , A61K31/506
CPC classification number: C07D401/10 , A01N43/54 , A01N47/02 , A01N53/00 , A61K31/4406 , A61K31/505 , A61K31/506 , A61K45/06 , C07D213/30 , C07D213/32 , C07D213/57 , C07D239/26 , C07D239/34 , A61K2300/00
Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US10167300B2
公开(公告)日：2019-01-01
申请号：US15914884
申请日：2018-03-07
Applicant: Dow AgroSciences LLC
Inventor： Michael R. Loso , Gary D. Gustafson , Asako Kubota , Maurice C. Yap , Zachary A. Buchan , Kimberly M. Steward , Michael T. Sullenberger , William J. Hoekstra , Christopher M. Yates
IPC: A01N43/40 , A01N43/54 , A01N43/713 , A01N43/78 , A01N55/00 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/695 , A61K45/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/06 , C07F7/08
Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US20180298038A1
公开(公告)日：2018-10-18
申请号：US15914884
申请日：2018-03-07
Applicant: Dow AgroSciences LLC
Inventor： Michael R. Loso , Gary D. Gustafson , Asako Kubota , Maurice C. Yap , Zachary A. Buchan , Kimberly M. Steward , Michael T. Sullenberger , William J. Hoekstra , Christopher M. Yates
IPC: C07F7/08 , C07D405/14 , A01N55/00 , C07D409/14 , A01N43/78 , C07D417/06 , A01N43/40 , A01N43/54 , A61K31/506 , A61K31/444 , C07D401/14 , A01N43/713 , A61K31/4439 , C07D401/06 , A61K45/06 , A61K31/695
CPC classification number: C07F7/0812 , A01N43/40 , A01N43/54 , A01N43/713 , A01N43/78 , A01N55/00 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/695 , A61K45/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/06
Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US09944664B2
公开(公告)日：2018-04-17
申请号：US14683907
申请日：2015-04-10
Applicant: Dow AgroSciences LLC
Inventor： Michael R. Loso , Gary D. Gustafson , Asako Kubota , Maurice C. Yap , Zachary A. Buchan , Kimberly M. Steward , Michael T. Sullenberger , William J. Hoekstra , Christopher M. Yates
IPC: C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/06 , A61K45/06 , A61K31/444 , A61K31/506 , A61K31/695 , A01N43/54 , A01N43/78 , A01N43/713 , A01N47/02 , A01N55/00 , C07F7/08 , A61K31/4439 , A01N43/40
CPC classification number: C07F7/0812 , A01N43/40 , A01N43/54 , A01N43/713 , A01N43/78 , A01N55/00 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/695 , A61K45/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/06
Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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Patent Agency Ranking
公开(公告)号：US20150246898A1
公开(公告)日：2015-09-03
申请号：US14427785
申请日：2013-09-12
Applicant: DOW AGROSCIENCES LLC
Inventor： Gary D. Gustafson , William Hoekstra , Michael R. Loso , Christopher M. Yates
IPC: C07D401/06 , A01N43/54 , A61K31/501 , A01N43/58 , A61K31/4965 , A01N43/60 , A61K31/4439 , A01N43/647 , A01N43/653 , C07D417/06 , A01N43/78 , A01N43/76 , A01N43/56 , C07D401/14 , A61K31/506
CPC classification number: C07D401/06 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/647 , A01N43/653 , A01N43/76 , A01N43/78 , A61K31/4439 , A61K31/4965 , A61K31/501 , A61K31/506 , A61K45/06 , C07D401/14 , C07D417/06
Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes. Living organisms have developed tightly regulated processes that specifically import metals, transport them to intracellular storage sites and ultimately transport them to sites of use. One of the most important functions of metals such as zinc and iron in biological systems is to enable the activity of metalloenzymes.
Abstract translation: 本发明描述了具有金属酶调节活性的化合物，以及治疗由这些金属酶介导的疾病，病症或症状的方法。 活生物体已经开发出严格规范的过程，特别是进口金属，将其运输到细胞内的储存场所，并最终将其运输到使用场所。 金属如锌和铁在生物系统中最重要的功能之一是使金属酶的活性得以实现。
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公开(公告)号：US20170233369A1
公开(公告)日：2017-08-17
申请号：US15586657
申请日：2017-05-04
Applicant: Dow AgroSciences LLC
Inventor： Michael R. Loso , Gary D. Gustafson , Asako Kubota , Maurice C. Yap , Zachary A. Buchan , Kimberly M. Steward , Michael T. Sullenberger , William J. Hoekstra , Christopher M. Yates
IPC: C07D401/10 , C07D239/34 , C07D213/32 , C07D213/57 , C07D239/26 , C07D213/30
CPC classification number: C07D401/10 , A01N43/54 , A01N47/02 , A01N53/00 , A61K31/4406 , A61K31/505 , A61K31/506 , A61K45/06 , C07D213/30 , C07D213/32 , C07D213/57 , C07D239/26 , C07D239/34 , A61K2300/00
Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US09663491B2
公开(公告)日：2017-05-30
申请号：US14683857
申请日：2015-04-10
Applicant: Dow AgroSciences LLC
Inventor： Michael R. Loso , Gary D. Gustafson , Asako Kubota , Maurice C. Yap , Zachary A. Buchan , Kimberly M. Steward , Michael T. Sullenberger , William J. Hoekstra , Christopher M. Yates
IPC: C07D401/10 , A01N43/54 , C07D239/26 , A61K31/505 , A61K31/506 , A01N47/02 , C07D213/30 , A61K31/4406 , C07D213/32 , C07D213/57 , C07D239/34 , A61K45/06 , A01N53/00
CPC classification number: C07D401/10 , A01N43/54 , A01N47/02 , A01N53/00 , A61K31/4406 , A61K31/505 , A61K31/506 , A61K45/06 , C07D213/30 , C07D213/32 , C07D213/57 , C07D239/26 , C07D239/34 , A61K2300/00
Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US20150291632A1
公开(公告)日：2015-10-15
申请号：US14683907
申请日：2015-04-10
Applicant: Dow AgroSciences LLC
Inventor： Michael R. Loso , Gary D. Gustafson , Asako Kubota , Maurice C. Yap , Zachary A. Buchan , Kimberly M. Steward , Michael T. Sullenberger , William J. Hoekstra , Christopher M. Yates
IPC: C07F7/08 , C07D401/06 , A61K31/4439 , A01N43/713 , C07D401/14 , A61K31/444 , A61K31/506 , A01N43/54 , A01N47/02 , A01N43/40 , C07D417/06 , A01N43/78 , C07D409/14 , A01N55/00 , A61K31/695 , C07D405/14 , A61K45/06
CPC classification number: C07F7/0812 , A01N43/40 , A01N43/54 , A01N43/713 , A01N43/78 , A01N55/00 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/695 , A61K45/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/06
Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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公开(公告)号：US20150291557A1
公开(公告)日：2015-10-15
申请号：US14683857
申请日：2015-04-10
Applicant: Dow AgroSciences LLC
Inventor： Michael R. Loso , Gary D. Gustafson , Asako Kubota , Maurice C. Yap , Zachary A. Buchan , Kimberly M. Steward , Michael T. Sullenberger , William J. Hoekstra , Christopher M. Yates
IPC: C07D401/10 , C07D239/26 , A61K31/505 , A61K31/506 , A01N47/02 , A61K45/06 , C07D213/30 , A61K31/4406 , C07D213/32 , C07D213/57 , C07D239/34 , A01N43/54 , A01N43/40
CPC classification number: C07D401/10 , A01N43/54 , A01N47/02 , A01N53/00 , A61K31/4406 , A61K31/505 , A61K31/506 , A61K45/06 , C07D213/30 , C07D213/32 , C07D213/57 , C07D239/26 , C07D239/34 , A61K2300/00
Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
Abstract translation: 本发明描述了具有金属酶调节活性的式I化合物，以及治疗由这些金属酶介导的疾病，病症或症状的方法。
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