公开(公告)号：US20220000891A1

公开(公告)日：2022-01-06

申请号：US17291481

申请日：2019-11-08

Applicant: DSM IP Assets B.V. ,  Midori USA, Inc.

Inventor： Britta BLOKKER ,  Stephane DUVAL ,  John Michael GEREMIA ,  Estefania PEREZ CALVO ,  Nathalie RICHARD ,  Jerome SCHMEISSER ,  Nicole SEIFERT ,  Viviane VERLHAC

IPC: A61K31/702 ,  A61K9/00 ,  A61P1/00 ,  A23K20/163 ,  A23K50/75 ,  A23K50/30

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat dysfunctions in a gastrointestinal barrier. The present disclosure further relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat infections.

公开(公告)号：US20230270705A1

公开(公告)日：2023-08-31

申请号：US18014780

申请日：2021-07-08

Applicant: DSM IP ASSETS B.V.

Inventor： Thanh-Van PHAM ,  Ateequr REHMAN ,  Nicole SEIFERT ,  Robert STEINERT ,  Wilbert SYBESMA

IPC: A61K31/202 ,  A61K31/07 ,  A61K31/375 ,  A61K31/525 ,  A61K31/015 ,  A61K31/197 ,  A61K31/122 ,  A61K31/593 ,  A61P1/00

CPC classification number: A61K31/202 ,  A61K31/07 ,  A61K31/375 ,  A61K31/525 ,  A61K31/015 ,  A61K31/197 ,  A61K31/122 ,  A61K31/593 ,  A61P1/00

Abstract: The population of Dialister spp. bacteria in the gut microbiome is lower in people with various diseases. We have found that administration of vitamins/vitamin combinations such as: beta-carotene, Vitamin A, Vitamin D, Vitamin B5, Vitamin B2, a combination of Vitamin B2 and Vitamin C, Vitamin K, DHA, or EPA, when administered directly to the large intestine, so that it provides nourishment to the gut microbiome directly, can result in an increase of Dialister spp.

公开(公告)号：US20250073253A1

公开(公告)日：2025-03-06

申请号：US18949971

申请日：2024-11-15

Applicant: DSM IP Assets B.V.

Inventor： Britta BLOKKER ,  Stephane DUVAL ,  John Michael GEREMIA ,  Estefania PEREZ CALVO ,  Nathalie RICHARD ,  Jerome SCHMEISSER ,  Nicole SEIFERT ,  Viviane VERLHAC

IPC: A61K31/702 ,  A23K20/163 ,  A23K50/30 ,  A23K50/75 ,  A61K9/00 ,  A61P1/00

Abstract: Methods of feeding animals are disclosed whereby feed additives are provided that modulate the gut microbiome to prevent or treat dysfunctions in a gastrointestinal barrier. The present disclosure further relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat infections.

公开(公告)号：US20240148739A1

公开(公告)日：2024-05-09

申请号：US18550642

申请日：2022-03-17

Applicant: DSM IP Assets B.V.

Inventor： Thanh-Van PHAM ,  Ateequr REHMAN ,  Nicole SEIFERT ,  Robert STEINERT ,  Wilbert SYBESMA

IPC: A61K31/525 ,  A61K31/015 ,  A61K31/355 ,  A61K31/375 ,  A61P31/04

CPC classification number: A61K31/525 ,  A61K31/015 ,  A61K31/355 ,  A61K31/375 ,  A61P31/04

Abstract: Delivery of antioxidants (Vitamin C, Vitamin E, riboflavin, and beta-carotene) directly to the large intestine were seen to decrease the population of Fusobacterium in the gut microbiome. An increased population of these bacteria is associated with Fusobacterium bacteremia as a co-morbidity with any one of: malignancy, dementia, chronic obstructive lung disease, diabetes, heart disease, alcoholism, disease(s) requiring dialysis, and stroke; colorectal cancer; digestive diseases including Ulcerative colitis; Crohn's disease; and/or Pediatric or adult inflammatory bowel disease; colorectal and other cancers, inflammatory bowel disease, adverse pregnancy-related conditions, and HIV.

公开(公告)号：US20230255930A1

公开(公告)日：2023-08-17

申请号：US18014387

申请日：2021-07-08

Applicant: DSM IP ASSETS B.V.

Inventor： Thanh-Van PHAM ,  Ateequr REHMAN ,  Nicole SEIFERT ,  Robert STEINERT ,  Wilbert SYBESMA

IPC: A61K31/375 ,  A61K31/525 ,  A61K31/593 ,  A61K31/025 ,  A61K31/197 ,  A61K45/06 ,  A61P43/00

CPC classification number: A61K31/375 ,  A61K31/025 ,  A61K31/197 ,  A61K31/525 ,  A61K31/593 ,  A61K45/06 ,  A61P43/00

Abstract: The population of Coprococcus spp. bacteria in the gut microbiome is lower in people with various diseases. We have found that administration of vitamins / vitamin combinations such as : the combination of Vitamin B2 and C; Vitamin D3; beta-carotene, and Vitamin B5, when administered directly to the gut, so that it provides nourishment to the gut microbiome directly, can result in an increase of Coprococcus spp.